Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

por Painter, George R, Natchus, Michael G, Cohen, Oren, Holman, Wendy, Painter, Wendy P
Publicado 2021

Preclinical and clinical development of the anti-HIV, anti-HBV oxathiolane nucleoside analog emtricitabine

por Painter, George R., Rimsky, Laurence T., Furman, Phillip A., Liotta, Dennis C., Schinazi, Raymond F., Quinn, Joseph B.
Publicado 2003

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity against SARS-CoV-2

por Painter, Wendy P., Holman, Wayne, Bush, Jim A., Almazedi, Firas, Malik, Hamzah, Eraut, Nicola C. J. E., Morin, Merribeth J., Szewczyk, Laura J., Painter, George R.
Publicado 2021

Analysis of the Potential for N(4)-Hydroxycytidine To Inhibit Mitochondrial Replication and Function

por Sticher, Zachary M., Lu, Gaofei, Mitchell, Deborah G., Marlow, Joshua, Moellering, Levi, Bluemling, Gregory R., Guthrie, David B., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A.
Publicado 2020

Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5′-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase

por Lu, Gaofei, Bluemling, Gregory R., Mao, Shuli, Hager, Michael, Gurale, Bharat P., Collop, Paul, Kuiper, Damien, Sana, Kasinath, Painter, George R., De La Rosa, Abel, Kolykhalov, Alexander A.
Publicado 2018

Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

por Cox, Robert M., Lieber, Carolin M., Wolf, Josef D., Karimi, Amirhossein, Lieberman, Nicole A. P., Sticher, Zachary M., Roychoudhury, Pavitra, Andrews, Meghan K., Krueger, Rebecca E., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A., Greninger, Alexander L., Plemper, Richard K.
Publicado 2023

4′-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication

por Sourimant, Julien, Lieber, Carolin M., Aggarwal, Megha, Cox, Robert M., Wolf, Josef D., Yoon, Jeong-Joong, Toots, Mart, Ye, Chengin, Sticher, Zachary, Kolykhalov, Alexander A., Martinez-Sobrido, Luis, Bluemling, Gregory R., Natchus, Michael G., Painter, George R., Plemper, Richard K.
Publicado 2021

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

por Lieber, Carolin M., Cox, Robert M., Sourimant, Julien, Wolf, Josef D., Juergens, Kate, Phung, Quynh, Saindane, Manohar T., Smith, Meghan K., Sticher, Zachary M., Kalykhalov, Alexander A., Natchus, Michael G., Painter, George R., Sakamoto, Kaori, Greninger, Alexander L., Plemper, Richard K.
Publicado 2022

Small-Molecule Antiviral β-d-N(4)-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

por Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George R., Baric, Ralph S., Denison, Mark R.
Publicado 2019

4’-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

por Lieber, Carolin M., Aggarwal, Megha, Yoon, Jeong-Joong, Cox, Robert M., Kang, Hae-Ji, Sourimant, Julien, Toots, Mart, Johnson, Scott K., Jones, Cheryl A., Sticher, Zachary M., Kolykhalov, Alexander A., Saindane, Manohar T., Tompkins, Stephen M., Planz, Oliver, Painter, George R., Natchus, Michael G., Sakamoto, Kaori, Plemper, Richard K.
Publicado 2023