Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?

por Chin, Venessa T., Vennin, Claire, Timpson, Paul, Pajic, Marina
Publicado 2017

Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy

por Parkin, Ashleigh, Man, Jennifer, Timpson, Paul, Pajic, Marina
Publicado 2019

Transient targeting of the pancreatic cancer stroma as a ‘fine-tuned’ anti-tumor and anti-metastatic therapy

por Vennin, Claire, Cox, Thomas R., Pajic, Marina, Timpson, Paul
Publicado 2017

An analysis of reported motivational orientation in students undertaking doctoral studies in the biomedical sciences

por Kemp, Matthew W, Molloy, Timothy J, Pajic, Marina, Chapman, Elaine
Publicado 2014

A CRISPR Path to Finding Vulnerabilities and Solving Drug Resistance: Targeting the Diverse Cancer Landscape and Its Ecosystem

por McLean, Benjamin, Istadi, Aji, Clack, Teleri, Vankan, Mezzalina, Schramek, Daniel, Neely, G. Gregory, Pajic, Marina
Publicado 2022

Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities

por Chin, Venessa T., Nagrial, Adnan M., Chou, Angela, Biankin, Andrew V., Gill, Anthony J., Timpson, Paul, Pajic, Marina
Publicado 2015

The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma

por Parkin, Ashleigh, Man, Jennifer, Chou, Angela, Nagrial, Adnan M, Samra, Jaswinder, Gill, Anthony J, Timpson, Paul, Pajic, Marina
Publicado 2018

The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment

por Pajic, Marina, Herrmann, David, Vennin, Claire, Conway, James RW, Chin, Venessa T, Johnsson, Anna-Karin E, Welch, Heidi CE, Timpson, Paul
Publicado 2015

Recruitment and Activation of Pancreatic Stellate Cells from the Bone Marrow in Pancreatic Cancer: A Model of Tumor-Host Interaction

por Scarlett, Christopher J., Colvin, Emily K., Pinese, Mark, Chang, David K., Morey, Adrienne L., Musgrove, Elizabeth A., Pajic, Marina, Apte, Minoti, Henshall, Susan M., Sutherland, Robert L., Kench, James G., Biankin, Andrew V.
Publicado 2011

Oral Squamous Cell Carcinoma in Young Patients Show Higher Rates of EGFR Amplification: Implications for Novel Personalized Therapy

por Satgunaseelan, Laveniya, Porazinski, Sean, Strbenac, Dario, Istadi, Aji, Willet, Cali, Chew, Tracy, Sadsad, Rosemarie, Palme, Carsten E., Lee, Jenny H., Boyer, Michael, Yang, Jean Y. H., Clark, Jonathan R., Pajic, Marina, Gupta, Ruta
Publicado 2021

Systematic functional identification of cancer multi-drug resistance genes

por Lau, Man-Tat, Ghazanfar, Shila, Parkin, Ashleigh, Chou, Angela, Rouaen, Jourdin R., Littleboy, Jamie B., Nessem, Danielle, Khuong, Thang M., Nevoltris, Damien, Schofield, Peter, Langley, David, Christ, Daniel, Yang, Jean, Pajic, Marina, Neely, G. Gregory
Publicado 2020

Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology

por Conway, James R. W., Vennin, Claire, Cazet, Aurélie S., Herrmann, David, Murphy, Kendelle J., Warren, Sean C., Wullkopf, Lena, Boulghourjian, Alice, Zaratzian, Anaiis, Da Silva, Andrew M., Pajic, Marina, Morton, Jennifer P., Cox, Thomas R., Timpson, Paul
Publicado 2017

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

por Martinelli, Paola, Carrillo-de Santa Pau, Enrique, Cox, Trevor, Sainz, Bruno, Dusetti, Nelson, Greenhalf, William, Rinaldi, Lorenzo, Costello, Eithne, Ghaneh, Paula, Malats, Núria, Büchler, Markus, Pajic, Marina, Biankin, Andrew V, Iovanna, Juan, Neoptolemos, John, Real, Francisco X
Publicado 2017

Returning individual research results for genome sequences of pancreatic cancer

por Johns, Amber L, Miller, David K, Simpson, Skye H, Gill, Anthony J, Kassahn, Karin S, Humphris, Jeremy L, Samra, Jaswinder S, Tucker, Katherine, Andrews, Lesley, Chang, David K, Waddell, Nicola, Pajic, Marina, Pearson, John V, Grimmond, Sean M, Biankin, Andrew V, Zeps, Nikolajs
Publicado 2014

∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

por Campbell, Hamish, Fleming, Nicholas, Roth, Imogen, Mehta, Sunali, Wiles, Anna, Williams, Gail, Vennin, Claire, Arsic, Nikola, Parkin, Ashleigh, Pajic, Marina, Munro, Fran, McNoe, Les, Black, Michael, McCall, John, Slatter, Tania L., Timpson, Paul, Reddel, Roger, Roux, Pierre, Print, Cristin, Baird, Margaret A., Braithwaite, Antony W.
Publicado 2018

CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy

por Khan, Tashbib, Lyons, Nicholas J., Gough, Madeline, Kwah, Kayden K.X., Cuda, Tahleesa J., Snell, Cameron E., Tse, Brian W., Sokolowski, Kamil A., Pearce, Lesley A., Adams, Timothy E., Rose, Stephen E., Puttick, Simon, Pajic, Marina, Adams, Mark N., He, Yaowu, Hooper, John D., Kryza, Thomas
Publicado 2022

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma

por Castillo, Lesley, Young, Adelaide I. J., Mawson, Amanda, Schafranek, Pia, Steinmann, Angela M., Nessem, Danielle, Parkin, Ashleigh, Johns, Amber, Chou, Angela, Law, Andrew M. K., Lucas, Morghan C., Murphy, Kendelle J., Deng, Niantao, Gallego-Ortega, David, Caldon, Catherine E., Timpson, Paul, Pajic, Marina, Ormandy, Christopher J., Oakes, Samantha R.
Publicado 2019

Mitochondrial mutations and metabolic adaptation in pancreatic cancer

por Hardie, Rae-Anne, van Dam, Ellen, Cowley, Mark, Han, Ting-Li, Balaban, Seher, Pajic, Marina, Pinese, Mark, Iconomou, Mary, Shearer, Robert F., McKenna, Jessie, Miller, David, Waddell, Nicola, Pearson, John V., Grimmond, Sean M., Sazanov, Leonid, Biankin, Andrew V., Villas-Boas, Silas, Hoy, Andrew J., Turner, Nigel, Saunders, Darren N.
Publicado 2017

qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles

por Song, Sarah, Nones, Katia, Miller, David, Harliwong, Ivon, Kassahn, Karin S., Pinese, Mark, Pajic, Marina, Gill, Anthony J., Johns, Amber L., Anderson, Matthew, Holmes, Oliver, Leonard, Conrad, Taylor, Darrin, Wood, Scott, Xu, Qinying, Newell, Felicity, Cowley, Mark J., Wu, Jianmin, Wilson, Peter, Fink, Lynn, Biankin, Andrew V., Waddell, Nic, Grimmond, Sean M., Pearson, John V.
Publicado 2012

Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma

por Kryza, Thomas, Khan, Tashbib, Puttick, Simon, Li, Chao, Sokolowski, Kamil A, Tse, Brian WC, Cuda, Tahleesa, Lyons, Nicholas, Gough, Madeline, Yin, Julia, Parkin, Ashleigh, Deryugina, Elena I, Quigley, James P., Law, Ruby H. P., Whisstock, James C., Riddell, Andrew D., Barbour, Andrew P., Wyld, David K., Thomas, Paul A., Rose, Stephen, Snell, Cameron E., Pajic, Marina, He, Yaowu, Hooper, John D.
Publicado 2020