Integrating stress signals—XBP1 as a novel mediator of intercellular crosstalk in non-alcoholic steatohepatitis

por Yu, Junjie, Pajvani, Utpal B.
Publicado 2022

Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma

por Yu, Junjie, Pajvani, Utpal B.
Publicado 2023

MTOR and Beta Cell Adaptation in T2D

por Bartolomé, Alberto, Pajvani, Utpal B
Publicado 2020

MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms

por Liang, Jiani, Chirikjian, Margot, Pajvani, Utpal B., Bartolomé, Alberto
Publicado 2022

Hypoglycemia Secondary to Sulfonylurea Ingestion in a Patient with End Stage Renal Disease: Results from a 72-Hour Fast

por Abraham, Alice, Rubin, Mishaela, Accili, Domenico, Bilezikian, John P., Pajvani, Utpal B.
Publicado 2015

Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex

por Bartolomé, Alberto, Liang, Jiani, Wang, Pengfei, Ho, David D., Pajvani, Utpal B.
Publicado 2021

An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β-Cell Mass Acquisition

por Bartolomé, Alberto, Ravussin, Yann, Yu, Junjie, Ferrante, Anthony W., Pajvani, Utpal B.
Publicado 2022

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

por Pajvani, Utpal B., Qiang, Li, Kangsamaksin, Thaned, Kitajewski, Jan, Ginsberg, Henry N., Accili, Domenico
Publicado 2013

Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity

por Aaron, Nicole, Zahr, Tarik, He, Ying, Yu, Lexiang, Mayfield, Brent, Pajvani, Utpal B., Qiang, Li
Publicado 2022

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2

por Kim, KyeongJin, Qiang, Li, Hayden, Matthew S., Sparling, David P., Purcell, Nicole H., Pajvani, Utpal B.
Publicado 2016

Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease

por Valenti, Luca, Mendoza, Rosa M., Rametta, Raffaela, Maggioni, Marco, Kitajewski, Chris, Shawber, Carrie J., Pajvani, Utpal B.
Publicado 2013

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1–dependent manner

por Pajvani, Utpal B., Shawber, Carrie J., Samuel, Varman T., Birkenfeld, Andreas L., Shulman, Gerald I., Kitajewski, Jan, Accili, Domenico
Publicado 2011

Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity

por Sparling, David P., Yu, Junjie, Kim, KyeongJin, Zhu, Changyu, Brachs, Sebastian, Birkenfeld, Andreas L., Pajvani, Utpal B.
Publicado 2015

Notch-mediated Ephrin signaling disrupts islet architecture and β cell function

por Bartolomé, Alberto, Suda, Nina, Yu, Junjie, Zhu, Changyu, Son, Jinsook, Ding, Hongxu, Califano, Andrea, Accili, Domenico, Pajvani, Utpal B.
Publicado 2022

Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver

por Kim, KyeongJin, Kang, Jin Ku, Jung, Young Hoon, Lee, Sang Bae, Rametta, Raffaela, Dongiovanni, Paola, Valenti, Luca, Pajvani, Utpal B.
Publicado 2021

Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis

por Kang, Jinku, Postigo-Fernandez, Jorge, Kim, KyeongJin, Zhu, Changyu, Yu, Junjie, Meroni, Marica, Mayfield, Brent, Bartolomé, Alberto, Dapito, Dianne H., Ferrante, Anthony W., Dongiovanni, Paola, Valenti, Luca, Creusot, Remi J., Pajvani, Utpal B.
Publicado 2023