Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification

por Kobet, Robert A., Pan, Xiaoping, Zhang, Baohong, Pak, Stephen C., Asch, Adam S., Lee, Myon-Hee
Publicado 2014

Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

por Shi, Qingya, Pei, Fen, Silverman, Gary A., Pak, Stephen C., Perlmutter, David H., Liu, Bing, Bahar, Ivet
Publicado 2020

Quantitative assessment of cell fate decision between autophagy and apoptosis

por Liu, Bing, Oltvai, Zoltán N., Bayır, Hülya, Silverman, Gary A., Pak, Stephen C., Perlmutter, David H., Bahar, Ivet
Publicado 2017

A Pro-Cathepsin L Mutant Is a Luminal Substrate for Endoplasmic-Reticulum-Associated Degradation in C. elegans

por Miedel, Mark T., Graf, Nathan J., Stephen, Kate E., Long, Olivia S., Pak, Stephen C., Perlmutter, David H., Silverman, Gary A., Luke, Cliff J.
Publicado 2012

Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency

por Cummings, Erin E., O’Reilly, Linda P., King, Dale E., Silverman, Richard M., Miedel, Mark T., Luke, Cliff J., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Publicado 2015

Fluphenazine Reduces Proteotoxicity in C. elegans and Mammalian Models of Alpha-1-Antitrypsin Deficiency

por Li, Jie, Pak, Stephen C., O’Reilly, Linda P., Benson, Joshua A., Wang, Yan, Hidvegi, Tunda, Hale, Pamela, Dippold, Christine, Ewing, Michael, Silverman, Gary A., Perlmutter, David H.
Publicado 2014

Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision

por Baldridge, Dustin, Wangler, Michael F., Bowman, Angela N., Yamamoto, Shinya, Schedl, Tim, Pak, Stephen C., Postlethwait, John H., Shin, Jimann, Solnica-Krezel, Lilianna, Bellen, Hugo J., Westerfield, Monte
Publicado 2021

Longitudinal modeling of human neuronal aging identifies RCAN1-TFEB pathway contributing to neurodegeneration of Huntington’s disease

por Lee, Seong Won, Oh, Young Mi, Victor, Matheus B., Strunilin, Ilya, Chen, Shawei, Dahiya, Sonika, Dolle, Roland E., Pak, Stephen C., Silverman, Gary A., Perlmutter, David H., Yoo, Andrew S.
Publicado 2023

An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z

por Wang, Yan, Cobanoglu, Murat C., Li, Jie, Hidvegi, Tunda, Hale, Pamela, Ewing, Michael, Chu, Andrew S., Gong, Zhenwei, Muzumdar, Radhika, Pak, Stephen C., Silverman, Gary A., Bahar, Ivet, Perlmutter, David H.
Publicado 2019

Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

por Gosai, Sager J., Kwak, Joon Hyeok, Luke, Cliff J., Long, Olivia S., King, Dale E., Kovatch, Kevin J., Johnston, Paul A., Shun, Tong Ying, Lazo, John S., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Publicado 2010

SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation

por Wang, Songyan, Luke, Cliff J., Pak, Stephen C., Shi, Victoria, Chen, Liyun, Moore, Jonathan, Andress, Arlise P., Jayachandran, Kay, Zhang, Jin, Huang, Yi, Platik, Marina, Apicelli, Anthony A., Schwarz, Julie K., Grigsby, Perry W., Silverman, Gary A., Markovina, Stephanie
Publicado 2022

CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans

por Thomas, Brian J., Wight, Ira E., Chou, Wendy Y. Y., Moreno, Marco, Dawson, Zachary, Homayouni, Arielle, Huang, Huiyan, Kim, Hyori, Jia, Hanna, Buland, Justin R., Wambach, Jennifer A., Cole, F. Sessions, Pak, Stephen C., Silverman, Gary A., Luke, Cliff J.
Publicado 2019

Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

por Markovina, Stephanie, Wang, Songyan, Henke, Lauren E, Luke, Cliff J, Pak, Stephen C, DeWees, Todd, Pfeifer, John D, Schwarz, Julie K, Liu, Weijun, Chen, Shuai, Mutch, David, Wang, Xiaowei, Powell, Matthew A, Siegel, Barry A, Dehdashti, Farrokh, Silverman, Gary A, Grigsby, Perry W
Publicado 2018

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

por Luke, Cliff J., Markovina, Stephanie, Good, Misty, Wight, Ira E., Thomas, Brian J., Linneman, John M., Lanik, Wyatt E., Koroleva, Olga, Coffman, Maggie R., Miedel, Mark T., Gong, Qingqing, Andress, Arlise, Campos Guerrero, Marlene, Wang, Songyan, Chen, LiYun, Beatty, Wandy L., Hausmann, Kelsey N., White, Frances V., Fitzpatrick, James A. J., Orvedahl, Anthony, Pak, Stephen C., Silverman, Gary A.
Publicado 2022

A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C

por Huang, Huiyan, Pan, Jiehong, Spielberg, David R., Hanchard, Neil A., Scott, Daryl A., Burrage, Lindsay C., Dai, Hongzheng, Murdock, David, Rosenfeld, Jill A., Mohammad, Ariz, Huang, Tao, Lindsey, Anika G., Kim, Hyori, Chen, Jian, Ramu, Avinash, Morrison, Stephanie A., Dawson, Zachary D., Hu, Alex Z., Tycksen, Eric, Silverman, Gary A., Baldridge, Dustin, Wambach, Jennifer A., Pak, Stephen C., Brody, Steven L., Schedl, Tim
Publicado 2022

Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling

por Marom, Ronit, Zhang, Bo, Washington, Megan E., Song, I-Wen, Burrage, Lindsay C., Rossi, Vittoria C., Berrier, Ava S., Lindsey, Anika, Lesinski, Jacob, Nonet, Michael L., Chen, Jian, Baldridge, Dustin, Silverman, Gary A., Sutton, V. Reid, Rosenfeld, Jill A., Tran, Alyssa A., Hicks, M. John, Murdock, David R., Dai, Hongzheng, Weis, MaryAnn, Jhangiani, Shalini N., Muzny, Donna M., Gibbs, Richard A., Caswell, Richard, Pottinger, Carrie, Cilliers, Deirdre, Stals, Karen, Eyre, David, Krakow, Deborah, Schedl, Tim, Pak, Stephen C., Lee, Brendan H.
Publicado 2023

Macrocephaly and developmental delay caused by missense variants in RAB5C

por Koop, Klaas, Yuan, Weimin, Tessadori, Federico, Rodriguez-Polanco, Wilmer R, Grubbs, Jeremy, Zhang, Bo, Osmond, Matt, Graham, Gail, Sawyer, Sarah, Conboy, Erin, Vetrini, Francesco, Treat, Kayla, Płoski, Rafal, Pienkowski, Victor Murcia, Kłosowska, Anna, Fieg, Elizabeth, Krier, Joel, Mallebranche, Coralie, Alban, Ziegler, Aldinger, Kimberly A, Ritter, Deborah, Macnamara, Ellen, Sullivan, Bonnie, Herriges, John, Alaimo, Joseph T, Helbig, Catherine, Ellis, Colin A, van Eyk, Clare, Gecz, Jozef, Farrugia, Daniel, Osei-Owusu, Ikeoluwa, Adès, Lesley, van den Boogaard, Marie-Jose, Fuchs, Sabine, Bakker, Jeroen, Duran, Karen, Dawson, Zachary D, Lindsey, Anika, Huang, Huiyan, Baldridge, Dustin, Silverman, Gary A, Grant, Barth D, Raizen, David, van Haaften, Gijs, Pak, Stephen C, Rehmann, Holger, Schedl, Tim, van Hasselt, Peter
Publicado 2023