OR14-6 The Role of the Angiopoietin-Tie2 Pathway in Microvascular Complications of Diabetes Mellitus

por Brigell, Mitchell, Pakola, Steve, Withers, Barbara, Gambino, Laura, Peters, Kevin
Publicado 2019

A phase I, dose-escalation study of TB-403, a monoclonal antibody directed against PlGF, in patients with advanced solid tumours

por Lassen, U, Nielsen, D L, Sørensen, M, Winstedt, L, Niskanen, T, Stenberg, Y, Pakola, S, Stassen, J-M, Glazer, S
Publicado 2012

Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers

por Santos, Joao, Heiniö, Camilla, Quixabeira, Dafne, Zafar, Sadia, Clubb, James, Pakola, Santeri, Cervera-Carrascon, Victor, Havunen, Riikka, Kanerva, Anna, Hemminki, Akseli
Publicado 2021

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

por Li, Guorong, Nottebaum, Astrid F., Brigell, Mitchell, Navarro, Iris D., Ipe, Ute, Mishra, Sarthak, Gomez-Caraballo, Maria, Schmitt, Heather, Soldo, Brandi, Pakola, Steve, Withers, Barbara, Peters, Kevin G., Vestweber, Dietmar, Stamer, W. Daniel
Publicado 2020

An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartmen...

por Pakola, Santeri, Quixabeira, Dafne C. A., Kudling, Tatiana V., Clubb, James H. A., Grönberg-Vähä-Koskela, Susanna, Basnet, Saru, Jirovec, Elise, Arias, Victor, Haybout, Lyna, Heiniö, Camilla, Santos, Joao M., Cervera-Carrascon, Victor, Havunen, Riikka, Anttila, Marjukka, Hemminki, Akseli
Publicado 2023

Improving the cytotoxic response of tumor-infiltrating lymphocytes towards advanced stage ovarian cancer with an oncolytic adenovirus expressing a human vIL-2 cytokine

por Quixabeira, D. C. A., Jirovec, E., Pakola, S., Havunen, R., Basnet, S., Santos, J. M., Kudling, T. V., Clubb, J. H. A., Haybout, L., Arias, V., Grönberg-Vähä-Koskela, S., Cervera-Carrascon, V., Pasanen, A., Anttila, M., Tapper, J., Kanerva, A., Hemminki, A.
Publicado 2023

Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer

por Clubb, James H. A., Kudling, Tatiana V., Heiniö, Camilla, Basnet, Saru, Pakola, Santeri, Cervera Carrascón, Víctor, Santos, João Manuel, Quixabeira, Dafne C. A., Havunen, Riikka, Sorsa, Suvi, Zheng, Vincent, Salo, Tuula, Bäck, Leif, Aro, Katri, Tulokas, Sanni, Loimu, Venla, Hemminki, Akseli
Publicado 2022

Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors

por Basnet, Saru, Santos, Joao M., Quixabeira, Dafne C.A., Clubb, James H.A., Grönberg-Vähä-Koskela, Susanna A.M., Arias, Victor, Pakola, Santeri, Kudling, Tatiana V., Heiniö, Camilla, Havunen, Riikka, Cervera-Carrascon, Victor, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Publicado 2022

Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer

por Kudling, Tatiana V., Clubb, James H.A., Pakola, Santeri, Quixabeira, Dafne C.A., Lähdeniemi, Iris A.K., Heiniö, Camilla, Arias, Victor, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao M., Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko I., Aaltonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W., Ilonen, Ilkka, Hemminki, Akseli
Publicado 2023

Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression

por Kudling, Tatiana V., Clubb, James H.A., Quixabeira, Dafne C.A., Santos, Joao M., Havunen, Riikka, Kononov, Alexander, Heiniö, Camilla, Cervera-Carrascon, Victor, Pakola, Santeri, Basnet, Saru, Grönberg-Vähä-Koskela, Susanna, Arias, Victor, Gladwyn-Ng, Ivan, Aro, Katri, Bäck, Leif, Räsänen, Jari, Ilonen, Ilkka, Borenius, Kristian, Räsänen, Mikko, Hemminki, Otto, Rannikko, Antti, Kanerva, Anna, Tapper, Johanna, Hemminki, Akseli
Publicado 2022

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting

por Clubb, James H. A., Kudling, Tatiana V., Girych, Mykhailo, Haybout, Lyna, Pakola, Santeri, Hamdan, Firas, Cervera-Carrascon, Víctor, Hemmes, Annabrita, Grönberg-Vähä-Koskela, Susanna, Santos, João Manuel, Quixabeira, Dafne C. A., Basnet, Saru, Heiniö, Camilla, Arias, Victor, Jirovec, Elise, Kaptan, Shreyas, Havunen, Riikka, Sorsa, Suvi, Erikat, Abdullah, Schwartz, Joel, Anttila, Marjukka, Aro, Katri, Viitala, Tapani, Vattulainen, Ilpo, Cerullo, Vincenzo, Kanerva, Anna, Hemminki, Akseli
Publicado 2023