Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay—Biological Implications

por Naseem, Afia, Pal, Akos, Gowan, Sharon, Asad, Yasmin, Donovan, Adam, Temesszentandrási-Ambrus, Csilla, Kis, Emese, Gaborik, Zsuzsanna, Bhalay, Gurdip, Raynaud, Florence
Publicado 2022

Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation

por Pal, Akos, Asad, Yasmin, Ruddle, Ruth, Henley, Alan T., Swales, Karen, Decordova, Shaun, Eccles, Suzanne A ., Collins, Ian, Garrett, Michelle D., De Bono, Johann, Banerji, Udai, Raynaud, Florence I.
Publicado 2020

Presence of human breast cancer xenograft changes the diurnal profile of amino acids in mice

por Junior, Rubens Paula, Sonehara, Nathália Martins, Jardim-Perassi, Bruna Victorasso, Pal, Akos, Asad, Yasmin, Almeida Chuffa, Luiz Gustavo, Chammas, Roger, Raynaud, Florence I., Zuccari, Debora A. P. C.
Publicado 2022

Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma

por Carvalho, Diana M., Richardson, Peter J., Olaciregui, Nagore, Stankunaite, Reda, Lavarino, Cinzia, Molinari, Valeria, Corley, Elizabeth A., Smith, Daniel P., Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence I., Temelso, Sara, Mackay, Alan, Overington, John P., Phelan, Anne, Sheppard, David, Mackinnon, Andrew, Zebian, Bassel, Al-Sarraj, Safa, Merve, Ashirwad, Pryce, Jeremy, Grill, Jacques, Hubank, Michael, Cruz, Ofelia, Morales La Madrid, Andres, Mueller, Sabine, Carcaboso, Angel M., Carceller, Fernando, Jones, Chris
Publicado 2022

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

por Bavetsias, Vassilios, Lanigan, Rachel M., Ruda, Gian Filippo, Atrash, Butrus, McLaughlin, Mark G., Tumber, Anthony, Mok, N. Yi, Le Bihan, Yann-Vaï, Dempster, Sally, Boxall, Katherine J., Jeganathan, Fiona, Hatch, Stephanie B., Savitsky, Pavel, Velupillai, Srikannathasan, Krojer, Tobias, England, Katherine S., Sejberg, Jimmy, Thai, Ching, Donovan, Adam, Pal, Akos, Scozzafava, Giuseppe, Bennett, James M., Kawamura, Akane, Johansson, Catrine, Szykowska, Aleksandra, Gileadi, Carina, Burgess-Brown, Nicola A., von Delft, Frank, Oppermann, Udo, Walters, Zoe, Shipley, Janet, Raynaud, Florence I., Westaway, Susan M., Prinjha, Rab K., Fedorov, Oleg, Burke, Rosemary, Schofield, Christopher J., Westwood, Isaac M., Bountra, Chas, Müller, Susanne, van Montfort, Rob L. M., Brennan, Paul E., Blagg, Julian
Publicado 2016