Vaccines against Human Carcinomas: Strategies to Improve Antitumor Immune Responses

por Palena, Claudia, Schlom, Jeffrey
Publicado 2010

Short-term EGFR blockade enhances immune-mediated cytotoxicity of EGFR mutant lung cancer cells: rationale for combination therapies

por Dominguez, Charli, Tsang, Kwong-Yok, Palena, Claudia
Publicado 2016

An immunotherapeutic intervention against tumor progression: Targeting a driver of the epithelial-to-mesenchymal transition

por Palena, Claudia, Fernando, Romaine I, Hamilton, Duane H
Publicado 2014

The role of oncogenic MUC1-C in brachyury-induced immunotherapy resistance

por David, Justin, Hamilton, Duane, Schlom, Jeffrey, Palena, Claudia
Publicado 2014

MUC1 upregulation promotes immune resistance in tumor cells undergoing brachyury-mediated epithelial-mesenchymal transition

por David, Justin M., Hamilton, Duane H., Palena, Claudia
Publicado 2016

Loss of the Cyclin-Dependent Kinase Inhibitor 1 in the Context of Brachyury-Mediated Phenotypic Plasticity Drives Tumor Resistance to Immune Attack

por Hamilton, Duane H., McCampbell, Kristen K., Palena, Claudia
Publicado 2018

Interleukin-8 drives epithelial-mesenchymal transition of human carcinomas

por Fernando, Romaine I, Hamilton, Duane H, Huang, Bruce, Palena, Claudia
Publicado 2013

Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody

por Hamilton, Duane H., Fernando, Romaine I., Schlom, Jeffrey, Palena, Claudia
Publicado 2014

The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance

por David, Justin M., Dominguez, Charli, Hamilton, Duane H., Palena, Claudia
Publicado 2016

Brachyury, a driver of tumor invasiveness and resistance to multiple therapies, is a novel immunotherapy target

por Palena, Claudia, Fernando, Romaine I, Hamilton, Duane H, Huang, Bruce, Schlom, Jeffrey
Publicado 2013

High levels of expression of the transcription factor Brachyury induce resistance of human carcinoma cells to immune-mediated attack

por Hamilton, Duane H, Huang, Bruce, Fernando, Romaine I, Tsang, Kwong-Yok, Palena, Claudia
Publicado 2013

Upregulation of oncogenic MUC1 by the EMT transcription factor brachyury mediates immunotherapy-resistance in tumor cells

por David, Justin M, Hamilton, Duane H, Dominguez, Charli L, Schlom, Jeffrey, Palena, Claudia
Publicado 2015

A novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells

por David, Justin M., Dominguez, Charli, McCampbell, Kristen K., Gulley, James L., Schlom, Jeffrey, Palena, Claudia
Publicado 2017

Generation of human T cells directed against an agonist epitope of Brachyury, a transcription factor involved in human tumor cell epithelial to mesenchymal transition (EMT)

por Boyerinas, Benjamin, Tucker, Jo A, Poole, Diane J, Jochéms, Caroline, Palena, Claudia, Schlom, Jeffrey, Tsang, Kwong Y
Publicado 2013

IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib

por Fernando, Romaine I., Hamilton, Duane H., Dominguez, Charli, David, Justin M., McCampbell, Kristen K., Palena, Claudia
Publicado 2016

Fulvestrant increases the susceptibility of enzalutamide-resistant prostate cancer cells to NK-mediated lysis

por Dahut, Madeline, Fousek, Kristen, Horn, Lucas A, Angstadt, Shantel, Qin, Haiyan, Hamilton, Duane H, Schlom, Jeffrey, Palena, Claudia
Publicado 2023

Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death

por Smith, Andressa A, Hodge, James, Garnett, Charlie, Farsaci, Benedetto, Palena, Claudia, Tsang, Kwong-Yok, Ferrone, Soldano, Gamiero, Sofia
Publicado 2013

Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances

por Lind, Hanne, Gameiro, Sofia R, Jochems, Caroline, Donahue, Renee N., Strauss, Julius, Gulley, James L, Palena, Claudia, Schlom, Jeffrey
Publicado 2020

Tumor-targeted interleukin-12 synergizes with entinostat to overcome PD-1/PD-L1 blockade-resistant tumors harboring MHC-I and APM deficiencies

por Minnar, Christine M, Chariou, Paul L, Horn, Lucas A, Hicks, Kristin C, Palena, Claudia, Schlom, Jeffrey, Gameiro, Sofia R
Publicado 2022

Vaccine Increases the Diversity and Activation of Intratumoral T Cells in the Context of Combination Immunotherapy

por Horn, Lucas A., Fousek, Kristen, Hamilton, Duane H., Hodge, James W., Zebala, John A., Maeda, Dean Y., Schlom, Jeffrey, Palena, Claudia
Publicado 2021