Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8(+) T cells eradicates peritoneal metastases in mouse models

por Di Trani, Claudia Augusta, Cirella, Assunta, Arrizabalaga, Leire, Bella, Ángela, Fernandez-Sendin, Myriam, Russo-Cabrera, Joan Salvador, Gomar, Celia, Olivera, Irene, Bolaños, Elizabeth, González-Gomariz, José, Álvarez, Maite, Etxeberria, Iñaki, Palencia, Belen, Teijeira, Álvaro, Melero, Ignacio, Berraondo, Pedro, Aranda, Fernando
Publicado 2022

Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists

por Cirella, Assunta, Bolaños, Elixabet, Luri-Rey, Carlos, Di Trani, Claudia Augusta, Olivera, Irene, Gomis, Gabriel, Glez-Vaz, Javier, Pinci, Beatrice, Garasa, Saray, Sánchez-Gregorio, Sandra, Azpilikueta, Arantza, Eguren-Santamaria, Iñaki, Valencia, Karmele, Palencia, Belén, Alvarez, Maite, Ochoa, Maria C., Teijeira, Álvaro, Berraondo, Pedro, Melero, Ignacio
Publicado 2023

Intratumoral injection of IL-12-encoding mRNA targeted to CSFR1 and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure

por Di Trani, Claudia Augusta, Cirella, Assunta, Arrizabalaga, Leire, Alvarez, Maite, Bella, Ángela, Fernandez-Sendin, Myriam, Russo-Cabrera, Joan Salvador, Gomar, Celia, Ardaiz, Nuria, Teijeira, Alvaro, Bolaños, Elixabet, González-Gomariz, José, Otano, Itziar, Aranda, Fernando, Palencia, Belén, Segués, Aina, Huang, Shuyu, van Duijnhoven, Sander M.J., van Elsas, Andrea, Melero, Ignacio, Berraondo, Pedro
Publicado 2023