Non-photoreceptor Expression of Tulp1 May Contribute to Extensive Retinal Degeneration in Tulp1-/- Mice

por Palfi, Arpad, Yesmambetov, Adlet, Humphries, Pete, Hokamp, Karsten, Farrar, G. Jane
Publicado 2020

A novel homozygous truncating GNAT1 mutation implicated in retinal degeneration

por Carrigan, Matthew, Duignan, Emma, Humphries, Pete, Palfi, Arpad, Kenna, Paul F, Farrar, G Jane
Publicado 2016

AAV-PHP.eB transduces both the inner and outer retina with high efficacy in mice

por Palfi, Arpad, Chadderton, Naomi, Millington-Ward, Sophia, Post, Iris, Humphries, Pete, Kenna, Paul F., Farrar, G. Jane
Publicado 2022

Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa

por Loscher, Carol J, Hokamp, Karsten, Kenna, Paul F, Ivens, Alasdair C, Humphries, Peter, Palfi, Arpad, Farrar, G Jane
Publicado 2007

AAV-Delivered Tulp1 Supplementation Therapy Targeting Photoreceptors Provides Minimal Benefit in Tulp1−/− Retinas

por Palfi, Arpad, Yesmambetov, Adlet, Millington-Ward, Sophia, Shortall, Ciara, Humphries, Pete, Kenna, Paul F., Chadderton, Naomi, Farrar, G. Jane
Publicado 2020

A Novel Retinal Ganglion Cell Promoter for Utility in AAV Vectors

por Hanlon, Killian S., Chadderton, Naomi, Palfi, Arpad, Blanco Fernandez, Alfonso, Humphries, Peter, Kenna, Paul F., Millington-Ward, Sophia, Farrar, G. Jane
Publicado 2017

SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration

por Finnegan, Laura K., Chadderton, Naomi, Kenna, Paul F., Palfi, Arpad, Carty, Michael, Bowie, Andrew G., Millington-Ward, Sophia, Farrar, G. Jane
Publicado 2022

Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho(–/–) mouse

por Palfi, Arpad, Chadderton, Naomi, O’Reilly, Mary, Nagel-Wolfrum, Kerstin, Wolfrum, Uwe, Bennett, Jean, Humphries, Peter, Kenna, Paul, Millington-Ward, Sophia, Farrar, Jane
Publicado 2015

Corrigendum to “Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho–/– mouse”

por Palfi, Arpad, Chadderton, Naomi, O’Reilly, Mary, Nagel-Wolfrum, Kerstin, Wolfrum, Uwe, Bennett, Jean, Humphries, Peter, Kenna, Paul, Millington-Ward, Sophia, Farrar, Jane
Publicado 2016

Toward an elucidation of the molecular genetics of inherited retinal degenerations

por Farrar, G. Jane, Carrigan, Matthew, Dockery, Adrian, Millington-Ward, Sophia, Palfi, Arpad, Chadderton, Naomi, Humphries, Marian, Kiang, Anna Sophia, Kenna, Paul F., Humphries, Pete
Publicado 2017

Novel 199 base pair NEFH promoter drives expression in retinal ganglion cells

por Millington-Ward, Sophia, Chadderton, Naomi, Berkeley, Megan, Finnegan, Laura K., Hanlon, Killian S., Carrigan, Matthew, Humphries, Peter, Kenna, Paul F., Palfi, Arpad, Farrar, G. Jane
Publicado 2020

microRNA regulatory circuits in a mouse model of inherited retinal degeneration

por Palfi, Arpad, Hokamp, Karsten, Hauck, Stefanie M., Vencken, Sebastian, Millington-Ward, Sophia, Chadderton, Naomi, Carrigan, Mathew, Kortvely, Elod, Greene, Catherine M., Kenna, Paul F., Farrar, G. Jane
Publicado 2016

Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit in Models of Mitochondrial Dysfunction

por Maloney, Daniel M., Chadderton, Naomi, Millington-Ward, Sophia, Palfi, Arpad, Shortall, Ciara, O’Byrne, James J., Cassidy, Lorraine, Keegan, David, Humphries, Peter, Kenna, Paul, Farrar, Gwyneth Jane
Publicado 2020

Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa

por Millington-Ward, Sophia, Chadderton, Naomi, O'Reilly, Mary, Palfi, Arpad, Goldmann, Tobias, Kilty, Claire, Humphries, Marian, Wolfrum, Uwe, Bennett, Jean, Humphries, Peter, Kenna, Paul F, Farrar, G Jane
Publicado 2011

Effective delivery of large genes to the retina by dual AAV vectors

por Trapani, Ivana, Colella, Pasqualina, Sommella, Andrea, Iodice, Carolina, Cesi, Giulia, de Simone, Sonia, Marrocco, Elena, Rossi, Settimio, Giunti, Massimo, Palfi, Arpad, Farrar, Gwyneth J, Polishchuk, Roman, Auricchio, Alberto
Publicado 2014

RPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models

por Millington-Ward, Sophia, Chadderton, Naomi, Finnegan, Laura K., Post, Iris J. M., Carrigan, Matthew, Nixon, Rachel, Humphries, Marian M., Humphries, Pete, Kenna, Paul F., Palfi, Arpad, Farrar, G. Jane
Publicado 2023

Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy

por Chadderton, Naomi, Palfi, Arpad, Millington-Ward, Sophia, Gobbo, Oliverio, Overlack, Nora, Carrigan, Matthew, O'Reilly, Mary, Campbell, Matthew, Ehrhardt, Carsten, Wolfrum, Uwe, Humphries, Peter, Kenna, Paul F, Jane Farrar, G
Publicado 2013

Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids

por Lane, Amelia, Jovanovic, Katarina, Shortall, Ciara, Ottaviani, Daniele, Panes, Anna Brugulat, Schwarz, Nele, Guarascio, Rosellina, Hayes, Matthew J., Palfi, Arpad, Chadderton, Naomi, Farrar, G. Jane, Hardcastle, Alison J., Cheetham, Michael E.
Publicado 2020

Optimisation of AAV-NDI1 Significantly Enhances Its Therapeutic Value for Correcting Retinal Mitochondrial Dysfunction

por Chadderton, Naomi, Palfi, Arpad, Maloney, Daniel M., Carrigan, Matthew, Finnegan, Laura K., Hanlon, Killian S., Shortall, Ciara, O’Reilly, Mary, Humphries, Peter, Cassidy, Lorraine, Kenna, Paul F., Millington-Ward, Sophia, Farrar, G. Jane
Publicado 2023

AAV‐mediated gene therapy improving mitochondrial function provides benefit in age‐related macular degeneration models

por Millington‐Ward, Sophia, Chadderton, Naomi, Finnegan, Laura K., Post, Iris J.M., Carrigan, Matthew, Gardiner, Tom, Peixoto, Elisa, Maloney, Daniel, Humphries, Marian M., Stitt, Alan, Léveillard, Thierry, Humphries, Pete, Kenna, Paul F., Palfi, Arpad, Farrar, G. Jane
Publicado 2022