Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2

por Tijono, Sofian M, Palmer, Brian D., Tomek, Petr, Flanagan, Jack U., Henare, Kimiora, Gamage, Swarna, Braun, Lukas, Ching, Lai-Ming
Publicado 2022

Synthetic studies towards isomeric pyrazolopyrimidines as potential ATP synthesis inhibitors of Mycobacterium tuberculosis. Structural correction of reported N-(6-(2-(dimethylamino...

por Choi, Peter J., Lu, Guo-Liang, Sutherland, Hamish S., Giddens, Anna C., Franzblau, Scott G., Cooper, Christopher B., Denny, William A., Palmer, Brian D.
Publicado 2022

Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876—A Less Toxic and More Potent Analogue of Bedaquiline

por Choi, Peter J., Conole, Daniel, Sutherland, Hamish S., Blaser, Adrian, Tong, Amy S.T., Cooper, Christopher B., Upton, Anna M., Palmer, Brian D., Denny, William A.
Publicado 2020

Synthesis and Structure–Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-N-(Pyridin-2-ylmethyl)Pyrazolo[1,5-a]Pyrimidin-7-Amines

por Sutherland, Hamish S., Choi, Peter J., Lu, Guo-Liang, Giddens, Anna C., Tong, Amy S. T., Franzblau, Scott G., Cooper, Christopher B., Palmer, Brian D., Denny, William A.
Publicado 2022

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

por Blaser, Adrian, Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha, Denny, William A., Palmer, Brian D.
Publicado 2019

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

por Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Blaser, Adrian, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha U., Denny, William A., Palmer, Brian D.
Publicado 2018

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

por Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Blaser, Adrian, Conole, Daniel, Franzblau, Scott G., Lotlikar, Manisha U., Cooper, Christopher B., Upton, Anna M., Denny, William A., Palmer, Brian D.
Publicado 2019

Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis

por Lu, Guo-Liang, Tong, Amy S.T., Conole, Daniel, Sutherland, Hamish S., Choi, Peter J., Franzblau, Scott G., Upton, Anna M., Lotlikar, Manisha U., Cooper, Christopher B., Denny, William A., Palmer, Brian D.
Publicado 2020

Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis

por Sutherland, Hamish S., Lu, Guo-Liang, Tong, Amy S.T., Conole, Daniel, Franzblau, Scott G., Upton, Anna M., Lotlikar, Manisha U., Cooper, Christopher B., Palmer, Brian D., Choi, Peter J., Denny, William A.
Publicado 2022

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

por Tong, Amy S. T., Choi, Peter J., Blaser, Adrian, Sutherland, Hamish S., Tsang, Sophia K. Y., Guillemont, Jerome, Motte, Magali, Cooper, Christopher B., Andries, Koen, Van den Broeck, Walter, Franzblau, Scott G., Upton, Anna M., Denny, William A., Palmer, Brian D., Conole, Daniel
Publicado 2017

Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units

por Choi, Peter J., Sutherland, Hamish S., Tong, Amy S.T., Blaser, Adrian, Franzblau, Scott G., Cooper, Christopher B., Lotlikar, Manisha U., Upton, Anna M., Guillemont, Jerome, Motte, Magali, Queguiner, Laurence, Andries, Koen, Van den Broeck, Walter, Denny, William A., Palmer, Brian D.
Publicado 2017