Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuro...

por Kay, Graham W, Palmer, David N
Publicado 2013

Electroretinography data from ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinoses

por Russell, Katharina N., Mitchell, Nadia L., Wellby, Martin P., Barrell, Graham K., Palmer, David N.
Publicado 2021

Conservation of Complete Trimethylation of Lysine-43 in the Rotor Ring of c-Subunits of Metazoan Adenosine Triphosphate (ATP) Synthases

por Walpole, Thomas B., Palmer, David N., Jiang, Huibing, Ding, Shujing, Fearnley, Ian M., Walker, John E.
Publicado 2015

The development of brain magnetic resonance approaches in large animal models for preclinical research

por Ella, Arsène, Barrière, David A, Adriaensen, Hans, Palmer, David N, Melzer, Tracy R, Mitchell, Nadia L, Keller, Matthieu
Publicado 2019

Molecular neuropathology of the synapse in sheep with CLN5 Batten disease

por Amorim, Inês S., Mitchell, Nadia L., Palmer, David N., Sawiak, Stephen J., Mason, Roger, Wishart, Thomas M., Gillingwater, Thomas H.
Publicado 2015

The locus for an inherited cataract in sheep maps to ovine chromosome 6

por Wilson, Gareth R.S., Morton, James D., Palmer, David N., McEwan, John C., Gately, Karl, Anderson, Rayna M., Dodds, Ken G.
Publicado 2012

Urine proteomics analysis of patients with neuronal ceroid lipofuscinoses

por Iwan, Katharina, Clayton, Robert, Mills, Philippa, Csanyi, Barbara, Gissen, Paul, Mole, Sara E., Palmer, David N., Mills, Kevin, Heywood, Wendy E.
Publicado 2020

Translational neurophysiology in sheep: measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep

por Perentos, Nicholas, Martins, Amadeu Q., Watson, Thomas C., Bartsch, Ullrich, Mitchell, Nadia L., Palmer, David N., Jones, Matthew W., Morton, A. Jennifer
Publicado 2015

Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ce...

por Russell, Katharina N., Mitchell, Nadia L., Anderson, Nigel G., Bunt, Craig R., Wellby, Martin P., Melzer, Tracy R., Barrell, Graham K., Palmer, David N.
Publicado 2018

Efficacy of dual intracerebroventricular and intravitreal CLN5 gene therapy in sheep prompts the first clinical trial to treat CLN5 Batten disease

por Murray, Samantha J., Wellby, Martin P., Barrell, Graham K., Russell, Katharina N., Deane, Ashley R., Wynyard, John R., Gray, Steven J., Palmer, David N., Mitchell, Nadia L.
Publicado 2023

Rapid and Progressive Regional Brain Atrophy in CLN6 Batten Disease Affected Sheep Measured with Longitudinal Magnetic Resonance Imaging

por Sawiak, Stephen J., Perumal, Sunthara Rajan, Rudiger, Skye R., Matthews, Loren, Mitchell, Nadia L., McLaughlan, Clive J., Bawden, C. Simon, Palmer, David N., Kuchel, Timothy, Morton, A. Jennifer
Publicado 2015

Progressive MRI brain volume changes in ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinosis

por Murray, Samantha J, Almuqbel, Mustafa M, Felton, Simon A, Palmer, Nickolas J, Myall, Daniel J, Shoorangiz, Reza, Ella, Arsène, Keller, Matthieu, Palmer, David N, Melzer, Tracy R, Mitchell, Nadia L
Publicado 2023

Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

por Kanninen, Katja M., Grubman, Alexandra, Meyerowitz, Jodi, Duncan, Clare, Tan, Jiang-Li, Parker, Sarah J., Crouch, Peter J., Paterson, Brett M., Hickey, James L., Donnelly, Paul S., Volitakis, Irene, Tammen, Imke, Palmer, David N., White, Anthony R.
Publicado 2013

Long-term safety and dose escalation of intracerebroventricular CLN5 gene therapy in sheep supports clinical translation for CLN5 Batten disease

por Mitchell, Nadia L., Murray, Samantha J., Wellby, Martin P., Barrell, Graham K., Russell, Katharina N., Deane, Ashley R., Wynyard, John R., Palmer, Madeleine J., Pulickan, Anila, Prendergast, Phillipa M., Casy, Widler, Gray, Steven J., Palmer, David N.
Publicado 2023

Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC

por O’Leary, Claire, Forte, Gabriella, Mitchell, Nadia L., Youshani, Amir Saam, Dyer, Adam, Wellby, Martin P., Russell, Katharina N., Murray, Samantha J., Jolinon, Nelly, Jones, Simon A, Stacey, Kevin, Davis, Daniel M., Henckaerts, Els, Palmer, David N., Kamaly-Asl, Ian, Bigger, Brian W.
Publicado 2023

Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment

por Eaton, Samantha L., Murdoch, Fraser, Rzechorzek, Nina M., Thompson, Gerard, Hartley, Claudia, Blacklock, Benjamin Thomas, Proudfoot, Chris, Lillico, Simon G., Tennant, Peter, Ritchie, Adrian, Nixon, James, Brennan, Paul M., Guido, Stefano, Mitchell, Nadia L., Palmer, David N., Whitelaw, C. Bruce A., Cooper, Jonathan D., Wishart, Thomas M.
Publicado 2022