The acidic pathway of bile acid synthesis: Not just an alternative pathway(☆)

por Pandak, William M., Kakiyama, Genta
Publicado 2019

Mitochondrial Cholesterol Metabolites in a Bile Acid Synthetic Pathway Drive Nonalcoholic Fatty Liver Disease: A Revised “Two-Hit” Hypothesis

por Kakiyama, Genta, Rodriguez-Agudo, Daniel, Pandak, William M.
Publicado 2023

Interactions between Bile Acids and Nuclear Receptors and Their Effects on Lipid Metabolism and Liver Diseases

por Wang, David Q.-H., Neuschwander-Tetri, Brent A., Portincasa, Piero, Pandak, William M.
Publicado 2012

25-Hydroxycholesterol 3-Sulfate Recovers Acetaminophen Induced Acute Liver Injury via Stabilizing Mitochondria in Mouse Models

por Wang, Yaping, Pandak, William M., Lesnefsky, Edward J., Hylemon, Phillip B., Ren, Shunlin
Publicado 2021

High Glucose Induces Lipid Accumulation via 25-Hydroxycholesterol DNA-CpG Methylation

por Wang, Yaping, Chen, Lanming, Pandak, William M., Heuman, Douglas, Hylemon, Phillip B., Ren, Shunlin
Publicado 2020

Identification of Novel Regulatory Cholesterol Metabolite, 5-Cholesten, 3β,25-Diol, Disulfate

por Ren, Shunlin, Kim, Jin Koung, Kakiyama, Genta, Rodriguez-Agudo, Daniel, Pandak, William M., Min, Hae-Ki, Ning, Yanxia
Publicado 2014

Berberine Inhibits HIV Protease Inhibitor-Induced Inflammatory Response by Modulating ER Stress Signaling Pathways in Murine Macrophages

por Zha, Weibin, Liang, Guang, Xiao, Jian, Studer, Elaine J., Hylemon, Phillip B., Pandak,, William M., Wang, Guangji, Li, Xiaokun, Zhou, Huiping
Publicado 2010

Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro...

por Sharon, Chetna, Baranwal, Somesh, Patel, Nirmita J., Rodriguez-Agudo, Daniel, Pandak, William M., Majumdar, Adhip PN, Krystal, Geoffrey, Patel, Bhaumik B.
Publicado 2015

Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via Gα(i)-protein-coupled receptors and the AKT pathway

por Cao, Risheng, Cronk, Zhumei Xu, Zha, Weibin, Sun, Lixin, Wang, Xuan, Fang, Youwen, Studer, Elaine, Zhou, Huiping, Pandak, William M., Dent, Paul, Gil, Gregorio, Hylemon, Phillip B.
Publicado 2010

Reduction of the HIV Protease Inhibitor-Induced ER Stress and Inflammatory Response by Raltegravir in Macrophages

por Zhang, Xiaoxuan, Cao, Risheng, Liu, Runping, Zhao, Renping, Huang, Yi, Gurley, Emily C., Hylemon, Phillip B., Pandak, William M., Wang, Guangji, Zhang, Luyong, Li, Xiaokun, Zhou, Huiping
Publicado 2014

Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages

por Zha, Weibin, Wang, Guangji, Xu, Weiren, Liu, Xuyuan, Wang, Yun, Zha, Beth S., Shi, Jian, Zhao, Qijin, Gerk, Phillip M., Studer, Elaine, Hylemon, Phillip B., Pandak, William M., Zhou, Huiping
Publicado 2013

Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2

por Liu, Runping, Zhao, Renping, Zhou, Xiqiao, Liang, Xiuyin, Campbell, Deanna JW, Zhang, Xiaoxuan, Zhang, Luyong, Shi, Ruihua, Wang, Guangji, Pandak, William M, Sirica, Alphonse E, Hylemon, Phillip B, Zhou, Huiping
Publicado 2014

Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways

por Wang, Yanyan, Tai, Yun-Ling, Zhao, Derrick, Zhang, Yuan, Yan, Junkai, Kakiyama, Genta, Wang, Xuan, Gurley, Emily C., Liu, Jinze, Liu, Jinpeng, Liu, Jimin, Lai, Guanhua, Hylemon, Phillip B., Pandak, William M., Chen, Weidong, Zhou, Huiping
Publicado 2021

Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease

por Minowa, Kei, Rodriguez-Agudo, Daniel, Suzuki, Mitsuyoshi, Muto, Yamato, Hirai, Saeko, Wang, Yaping, Su, Lianyong, Zhou, Huiping, Chen, Qun, Lesnefsky, Edward J., Mitamura, Kuniko, Ikegawa, Shigeo, Takei, Hajime, Nittono, Hiroshi, Fuchs, Michael, Pandak, William M., Kakiyama, Genta
Publicado 2023

Gut microbial composition can differentially regulate bile acid synthesis in humanized mice

por Kang, Dae Joong, Hylemon, Phillip B, Gillevet, Patrick M, Sartor, R. Balfour, Betrapally, Naga S., Kakiyama, Genta, Sikaroodi, Masoumeh, Takei, Hajime, Nittono, Hiroshi, Zhou, Huiping, Pandak, William M., Yang, Jing, Jiao, Chunhua, Li, Xiaojiaoyang, Lippman, H. Robert, Heuman, Douglas M., Bajaj, Jasmohan S.
Publicado 2017

Rifaximin Exerts Beneficial Effects Independent of its Ability to Alter Microbiota Composition

por Kang, Dae J, Kakiyama, Genta, Betrapally, Naga S, Herzog, Jeremy, Nittono, Hiroshi, Hylemon, Phillip B, Zhou, Huiping, Carroll, Ian, Yang, Jing, Gillevet, Patrick M, Jiao, Chunhua, Takei, Hajime, Pandak, William M, Iida, Takashi, Heuman, Douglas M, Fan, Sili, Fiehn, Oliver, Kurosawa, Takao, Sikaroodi, Masoumeh, Sartor, R B, Bajaj, Jasmohan S
Publicado 2016

Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Ca...

por Robertson, Douglas J., Dominitz, Jason A., Beed, Alexander, Boardman, Kathy D., Del Curto, Barbara J., Guarino, Peter D., Imperiale, Thomas F., LaCasse, Andrew, Larson, Meaghan F., Gupta, Samir, Lieberman, David, Planeta, Beata, Shaukat, Aasma, Sultan, Shanaz, Menees, Stacy B., Saini, Sameer D., Schoenfeld, Philip, Goebel, Stephan, von Rosenvinge, Erik C., Baffy, Gyorgy, Halasz, Ildiko, Pedrosa, Marcos C., Kahng, Lyn Sue, Cassim, Riaz, Greer, Katarina B., Kinnard, Margaret F., Bhatt, Divya B., Dunbar, Kerry B., Harford, William V., Mengshol, John A., Olson, Jed E., Patel, Swati G., Antaki, Fadi, Fisher, Deborah A., Sullivan, Brian A., Lenza, Christopher, Prajapati, Devang N., Wong, Helen, Beyth, Rebecca, Lieb, John G., Manlolo, Joseph, Ona, Fernando V., Cole, Rhonda A., Khalaf, Natalia, Kahi, Charles J., Kohli, Divyanshoo Rai, Rai, Tarun, Sharma, Prateek, Anastasiou, Jiannis, Hagedorn, Curt, Fernando, Ronald S., Jackson, Christian S., Jamal, M. Mazen, Lee, Robert H., Merchant, Farrukh, May, Folasade P., Pisegna, Joseph R., Omer, Endashaw, Parajuli, Dipendra, Said, Adnan, Nguyen, Toan D., Tombazzi, Claudio Ruben, Feldman, Paul A., Jacob, Leslie, Koppelman, Rachel N., Lehenbauer, Kyle P., Desai, Deepak S., Madhoun, Mohammad F., Tierney, William M., Ho, Minh Q., Hockman, Heather J., Lopez, Christopher, Carter Paulson, Emily, Tobi, Martin, Pinillos, Hugo L., Young, Michele, Ho, Nancy C., Mascarenhas, Ranjan, Promrat, Kirrichai, Mutha, Pritesh R., Pandak, William M., Shah, Tilak, Schubert, Mitchell, Pancotto, Frank S., Gawron, Andrew J., Underwood, Amelia E., Ho, Samuel B., Magno-Pagatzaurtundua, Priscilla, Toro, Doris H., Beymer, Charles H., Kaz, Andrew M., Elwing, Jill, Gill, Jeffrey A., Goldsmith, Susan F., Yao, Michael D., Protiva, Petr, Pohl, Heiko, Kyriakides, Tassos
Publicado 2023