Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy

por Huyghe, Deborah, Denninger, Andrew R., Voss, Caroline M., Frank, Pernille, Gao, Ning, Brandon, Nicholas, Waagepetersen, Helle S., Ferguson, Andrew D., Pangalos, Menelas, Doig, Peter, Moss, Stephen J.
Publicado 2019

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons

por Robbins, Jacqueline P., Perfect, Leo, Ribe, Elena M., Maresca, Marcello, Dangla-Valls, Adrià, Foster, Evangeline M., Killick, Richard, Nowosiad, Paulina, Reid, Matthew J., Polit, Lucia Dutan, Nevado, Alejo J., Ebner, Daniel, Bohlooly-Y, Mohammad, Buckley, Noel, Pangalos, Menelas N., Price, Jack, Lovestone, Simon
Publicado 2018

LB5. PROVENT: Phase 3 Study of Efficacy and Safety of AZD7442 (Tixagevimab/Cilgavimab) for Pre-exposure Prophylaxis of COVID-19 in Adults

por Levin, Myron J, Ustianowski, Andrew, De Wit, Stéphane, Launay, Odile, Avila, Miles, Seegobin, Seth, Templeton, Alison, Yuan, Yuan, Ambery, Philip, Arends, Rosalinda H, Beavon, Rohini, Near, Karen A, Padilla, Kelly W, Psachoulia, Konstantina, Sharbaugh, Audrey, Streicher, Katie, Pangalos, Menelas N, Esser, Mark T, Gasser, Robert A
Publicado 2021

AZD7442 (Tixagevimab/Cilgavimab) for Post-Exposure Prophylaxis of Symptomatic Coronavirus Disease 2019

por Levin, Myron J, Ustianowski, Andrew, Thomas, Steven, Templeton, Alison, Yuan, Yuan, Seegobin, Seth, Houlihan, Catherine F, Menendez-Perez, Ibrahim, Pollett, Simon, Arends, Rosalinda H, Beavon, Rohini, Dey, Kanika, Garbes, Pedro, Kelly, Elizabeth J, Koh, Gavin C K W, Ivanov, Stefan, Near, Karen A, Sharbaugh, Audrey, Streicher, Katie, Pangalos, Menelas N, Esser, Mark T
Publicado 2022

Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-cont...

por Montgomery, Hugh, Hobbs, F D Richard, Padilla, Francisco, Arbetter, Douglas, Templeton, Alison, Seegobin, Seth, Kim, Kenneth, Campos, Jesus Abraham Simón, Arends, Rosalinda H, Brodek, Bryan H, Brooks, Dennis, Garbes, Pedro, Jimenez, Julieta, Koh, Gavin C K W, Padilla, Kelly W, Streicher, Katie, Viani, Rolando M, Alagappan, Vijay, Pangalos, Menelas N, Esser, Mark T
Publicado 2022

Rare variant associations with plasma protein levels in the UK Biobank

por Dhindsa, Ryan S., Burren, Oliver S., Sun, Benjamin B., Prins, Bram P., Matelska, Dorota, Wheeler, Eleanor, Mitchell, Jonathan, Oerton, Erin, Hristova, Ventzislava A., Smith, Katherine R., Carss, Keren, Wasilewski, Sebastian, Harper, Andrew R., Paul, Dirk S., Fabre, Margarete A., Runz, Heiko, Viollet, Coralie, Challis, Benjamin, Platt, Adam, Vitsios, Dimitrios, Ashley, Euan A., Whelan, Christopher D., Pangalos, Menelas N., Wang, Quanli, Petrovski, Slavé
Publicado 2023

Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19

por Levin, Myron J., Ustianowski, Andrew, De Wit, Stéphane, Launay, Odile, Avila, Miles, Templeton, Alison, Yuan, Yuan, Seegobin, Seth, Ellery, Adam, Levinson, Dennis J., Ambery, Philip, Arends, Rosalinda H., Beavon, Rohini, Dey, Kanika, Garbes, Pedro, Kelly, Elizabeth J., Koh, Gavin C.K.W., Near, Karen A., Padilla, Kelly W., Psachoulia, Konstantina, Sharbaugh, Audrey, Streicher, Katie, Pangalos, Menelas N., Esser, Mark T.
Publicado 2022

Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes

por Nag, Abhishek, Dhindsa, Ryan S., Mitchell, Jonathan, Vasavda, Chirag, Harper, Andrew R., Vitsios, Dimitrios, Ahnmark, Andrea, Bilican, Bilada, Madeyski-Bengtson, Katja, Zarrouki, Bader, Zoghbi, Anthony W., Wang, Quanli, Smith, Katherine R., Alegre-Díaz, Jesus, Kuri-Morales, Pablo, Berumen, Jaime, Tapia-Conyer, Roberto, Emberson, Jonathan, Torres, Jason M., Collins, Rory, Smith, David M., Challis, Benjamin, Paul, Dirk S., Bohlooly-Y, Mohammad, Snowden, Mike, Baker, David, Fritsche-Danielson, Regina, Pangalos, Menelas N., Petrovski, Slavé
Publicado 2022

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in non-human primates and has an extended half-life in humans

por Loo, Yueh-Ming, McTamney, Patrick M., Arends, Rosalinda H., Abram, Michael E., Aksyuk, Anastasia A., Diallo, Seme, Flores, Daniel J., Kelly, Elizabeth J., Ren, Kuishu, Roque, Richard, Rosenthal, Kim, Streicher, Katie, Tuffy, Kevin M., Bond, Nicholas J., Cornwell, Owen, Bouquet, Jerome, Cheng, Lily I., Dunyak, James, Huang, Yue, Rosenbaum, Anton I., Reddy, Venkatesh Pilla, Andersen, Hanne, Carnahan, Robert H., Crowe, James E., Kuehne, Ana I., Herbert, Andrew S., Dye, John M., Bright, Helen, Kallewaard, Nicole L., Pangalos, Menelas N., Esser, Mark T.
Publicado 2022

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine

por Falsey, Ann R., Sobieszczyk, Magdalena E., Hirsch, Ian, Sproule, Stephanie, Robb, Merlin L., Corey, Lawrence, Neuzil, Kathleen M., Hahn, William, Hunt, Julie, Mulligan, Mark J., McEvoy, Charlene, DeJesus, Edwin, Hassman, Michael, Little, Susan J., Pahud, Barbara A., Durbin, Anna, Pickrell, Paul, Daar, Eric S., Bush, Larry, Solis, Joel, Carr, Quito Osuna, Oyedele, Temitope, Buchbinder, Susan, Cowden, Jessica, Vargas, Sergio L., Benavides, Alfredo Guerreros, Call, Robert, Keefer, Michael C., Kirkpatrick, Beth D., Pullman, John, Tong, Tina, Isaacs, Margaret Brewinski, Benkeser, David, Janes, Holly E., Nason, Martha C., Green, Justin A., Kelly, Elizabeth J., Maaske, Jill, Mueller, Nancy, Shoemaker, Kathryn, Takas, Therese, Marshall, Richard P., Pangalos, Menelas N., Villafana, Tonya, Gonzalez-Lopez, Antonio
Publicado 2021

Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility

por Douthwaite, Julie A., Brown, Christopher A., Ferdinand, John R., Sharma, Rahul, Elliott, Jane, Taylor, Molly A., Malintan, Nancy T., Duvoisin, Hannah, Hill, Thomas, Delpuech, Oona, Orton, Alexandra L., Pitt, Haidee, Kuenzi, Fred, Fish, Simon, Nicholls, David J., Cuthbert, Anna, Richards, Ian, Ratcliffe, Giles, Upadhyay, Abhishek, Marklew, Abigail, Hewitt, Craig, Ross-Thriepland, Douglas, Brankin, Christopher, Chodorge, Matthieu, Browne, Gareth, Mander, Palwinder K., DeWildt, Ruud M., Weaver, Shane, Smee, Penny A., van Kempen, Joost, Bartlett, Jon G., Allen, Paula M., Koppe, Emma L., Ashby, Charlotte A., Phipps, Julian D., Mehta, Nalini, Brierley, David J., Tew, David G., Leveridge, Melanie V., Baddeley, Stuart M., Goodfellow, Ian G., Green, Clive, Abell, Chris, Neely, Andy, Waddell, Ian, Rees, Steve, Maxwell, Patrick H., Pangalos, Menelas N., Howes, Rob, Clark, Roger
Publicado 2022