A novel small-molecule MRCK inhibitor blocks cancer cell invasion

por Unbekandt, Mathieu, Croft, Daniel R, Crighton, Diane, Mezna, Mokdad, McArthur, Duncan, McConnell, Patricia, Schüttelkopf, Alexander W, Belshaw, Simone, Pannifer, Andrew, Sime, Mairi, Bower, Justin, Drysdale, Martin, Olson, Michael F
Publicado 2014

Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6

por De Vita, Elena, Smits, Niels, van den Hurk, Helma, Beck, Elizabeth M., Hewitt, Joanne, Baillie, Gemma, Russell, Emily, Pannifer, Andrew, Hamon, Véronique, Morrison, Angus, McElroy, Stuart P., Jones, Philip, Ignatenko, Natalia A., Gunkel, Nikolas, Miller, Aubry K.
Publicado 2019

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

por Francis, Stuart, Croft, Daniel, Schüttelkopf, Alexander W., Parry, Charles, Pugliese, Angelo, Cameron, Ken, Claydon, Sophie, Drysdale, Martin, Gardner, Claire, Gohlke, Andrea, Goodwin, Gillian, Gray, Christopher H., Konczal, Jennifer, McDonald, Laura, Mezna, Mokdad, Pannifer, Andrew, Paul, Nikki R., Machesky, Laura, McKinnon, Heather, Bower, Justin
Publicado 2019

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

por M. Beck, Elizabeth, Parnell, Euan, Cowley, Angela, Porter, Alison, Gillespie, Jonathan, Robinson, John, Robinson, Lindsay, Pannifer, Andrew D., Hamon, Veronique, Jones, Philip, Morrison, Angus, McElroy, Stuart, Timmerman, Martin, Rutjes, Helma, Mahajan, Pravin, Wiejak, Jolanta, Luchowska-Stańska, Urszula, Morgan, David, Barker, Graeme, Rehmann, Holger, Yarwood, Stephen J.
Publicado 2019