Clues from a missense mutation of the adenosine A(1) receptor gene associated with early-onset Parkinson’s disease

por Ferré, Sergi, Pardo, Leonardo, Ciruela, Francisco
Publicado 2023

The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor

por Stanley, Nathaniel, Pardo, Leonardo, Fabritiis, Gianni De
Publicado 2016

Molecular Basis of Ligand Dissociation in β-Adrenergic Receptors

por González, Angel, Perez-Acle, Tomas, Pardo, Leonardo, Deupi, Xavier
Publicado 2011

GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors

por Rios, Santiago, Fernandez, Marta F., Caltabiano, Gianluigi, Campillo, Mercedes, Pardo, Leonardo, Gonzalez, Angel
Publicado 2015

Identifying human diamine sensors for death related putrescine and cadaverine molecules

por Izquierdo, Cristina, Gómez-Tamayo, José C., Nebel, Jean-Christophe, Pardo, Leonardo, Gonzalez, Angel
Publicado 2018

TMalphaDB and TMbetaDB: web servers to study the structural role of sequence motifs in α-helix and β-barrel domains of membrane proteins

por Perea, Marc, Lugtenburg, Ivar, Mayol, Eduardo, Cordomí, Arnau, Deupí, Xavier, Pardo, Leonardo, Olivella, Mireia
Publicado 2015

The mutational landscape of human olfactory G protein-coupled receptors

por Jimenez, Ramón Cierco, Casajuana-Martin, Nil, García-Recio, Adrián, Alcántara, Lidia, Pardo, Leonardo, Campillo, Mercedes, Gonzalez, Angel
Publicado 2021

The size matters? A computational tool to design bivalent ligands

por Pérez-Benito, Laura, Henry, Andrew, Matsoukas, Minos-Timotheos, Lopez, Laura, Pulido, Daniel, Royo, Miriam, Cordomí, Arnau, Tresadern, Gary, Pardo, Leonardo
Publicado 2018

Ligand chain length drives activation of lipid G protein-coupled receptors

por Troupiotis-Tsaïlaki, Anastassia, Zachmann, Julian, González-Gil, Inés, Gonzalez, Angel, Ortega-Gutiérrez, Silvia, López-Rodríguez, Maria L., Pardo, Leonardo, Govaerts, Cedric
Publicado 2017

Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A(2A) receptor

por Navarro, Gemma, Gonzalez, Angel, Campanacci, Stefano, Rivas-Santisteban, Rafael, Reyes-Resina, Irene, Casajuana-Martin, Nil, Cordomí, Arnau, Pardo, Leonardo, Franco, Rafael
Publicado 2020

A Single Point Mutation Blocks the Entrance of Ligands to the Cannabinoid CB(2) Receptor via the Lipid Bilayer

por Casajuana-Martin, Nil, Navarro, Gemma, Gonzalez, Angel, Llinas del Torrent, Claudia, Gómez-Autet, Marc, Quintana García, Aleix, Franco, Rafael, Pardo, Leonardo
Publicado 2022

Ligand-regulated oligomerization of β(2)-adrenoceptors in a model lipid bilayer

por Fung, Juan José, Deupi, Xavier, Pardo, Leonardo, Yao, Xiao Jie, Velez-Ruiz, Gisselle A, DeVree, Brian T, Sunahara, Roger K, Kobilka, Brian K
Publicado 2009

Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB(2) Receptor

por Morales, Paula, Navarro, Gemma, Gómez‐Autet, Marc, Redondo, Laura, Fernández‐Ruiz, Javier, Pérez‐Benito, Laura, Cordomí, Arnau, Pardo, Leonardo, Franco, Rafael, Jagerovic, Nadine
Publicado 2020

Crystal structure of the μ-opioid receptor bound to a morphinan antagonist

por Manglik, Aashish, Kruse, Andrew C., Kobilka, Tong Sun, Thian, Foon Sun, Mathiesen, Jesper M., Sunahara, Roger K., Pardo, Leonardo, Weis, William I., Kobilka, Brian K., Granier, Sébastien
Publicado 2012

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

por Navarro, Gemma, Cordomí, Arnau, Casadó-Anguera, Verónica, Moreno, Estefanía, Cai, Ning-Sheng, Cortés, Antoni, Canela, Enric I., Dessauer, Carmen W., Casadó, Vicent, Pardo, Leonardo, Lluís, Carme, Ferré, Sergi
Publicado 2018

The Leu/Val(6.51) Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ(9)-Tetrahydrocannabinol

por Llinas del Torrent, Claudia, Raïch, Iu, Gonzalez, Angel, Casajuana-Martin, Nil, Lillo, Jaume, Rebassa, Joan Biel, Ferreiro-Vera, Carlos, Sánchez de Medina, Verónica, Franco, Rafael, Navarro, Gemma, Pardo, Leonardo
Publicado 2023

Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects

por Gallo, Maria, Moreno, Estefanía, Defaus, Sira, Ortega-Alvaro, Antonio, Gonzalez, Angel, Robledo, Patricia, Cavaco, Marco, Neves, Vera, Castanho, Miguel A. R. B., Casadó, Vicent, Pardo, Leonardo, Maldonado, Rafael, Andreu, David
Publicado 2021

Cross-communication between G(i) and G(s) in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain

por Navarro, Gemma, Cordomí, Arnau, Brugarolas, Marc, Moreno, Estefanía, Aguinaga, David, Pérez-Benito, Laura, Ferre, Sergi, Cortés, Antoni, Casadó, Vicent, Mallol, Josefa, Canela, Enric I., Lluís, Carme, Pardo, Leonardo, McCormick, Peter J., Franco, Rafael
Publicado 2018

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB(1) and Serotonin 5-HT(2A) Receptors

por Viñals, Xavier, Moreno, Estefanía, Lanfumey, Laurence, Cordomí, Arnau, Pastor, Antoni, de La Torre, Rafael, Gasperini, Paola, Navarro, Gemma, Howell, Lesley A., Pardo, Leonardo, Lluís, Carmen, Canela, Enric I., McCormick, Peter J., Maldonado, Rafael, Robledo, Patricia
Publicado 2015

A new serotonin 5-HT(6) receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding

por González-Vera, Juan A., Medina, Rocío A., Martín-Fontecha, Mar, Gonzalez, Angel, de la Fuente, Tania, Vázquez-Villa, Henar, García-Cárceles, Javier, Botta, Joaquín, McCormick, Peter J., Benhamú, Bellinda, Pardo, Leonardo, López-Rodríguez, María L.
Publicado 2017