Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?

por Checler, Frédéric, Afram, Elissa, Pardossi-Piquard, Raphaëlle, Lauritzen, Inger
Publicado 2021

Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

por Lauritzen, Inger, Bécot, Anaïs, Bourgeois, Alexandre, Pardossi-Piquard, Raphaëlle, Biferi, Maria-Grazia, Barkats, Martine, Checler, Fréderic
Publicado 2019

The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse

por Lauritzen, Inger, Pardossi-Piquard, Raphaelle, Druon, Charlotte, Brigham, Elizabeth, Abraham, Daniel, Ranaldi, Sébatien, Chami, Linda, Dunys, Julie, Checler, Fréderic
Publicado 2013

The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer’s Disease Models

por Bécot, Anaïs, Pardossi-Piquard, Raphaëlle, Bourgeois, Alexandre, Duplan, Eric, Xiao, Qingli, Diwan, Abhinav, Lee, Jin-Moo, Lauritzen, Inger, Checler, Frédéric
Publicado 2020

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage

por Pardossi-Piquard, Raphaëlle, Böhm, Christopher, Chen, Fusheng, Kanemoto, Soshi, Checler, Frédéric, Schmitt-Ulms, Gerold, St. George-Hyslop, Peter, Fraser, Paul E.
Publicado 2009

The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production

por Afram, Elissa, Lauritzen, Inger, Bourgeois, Alexandre, El Manaa, Wejdane, Duplan, Eric, Chami, Mounia, Valverde, Audrey, Charlotte, Bauer, Pardossi-Piquard, Raphaëlle, Checler, Frederic
Publicado 2023

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

por Lauritzen, Inger, Pardossi-Piquard, Raphaëlle, Bourgeois, Alexandre, Pagnotta, Sophie, Biferi, Maria-Grazia, Barkats, Martine, Lacor, Pascale, Klein, William, Bauer, Charlotte, Checler, Frederic
Publicado 2016

APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes

por Pardossi-Piquard, Raphaëlle, Yang, Seung-Pil, Kanemoto, Soshi, Gu, Yongjun, Chen, Fusheng, Böhm, Christopher, Sevalle, Jean, Li, Tong, Wong, Philip C., Checler, Frédéric, Schmitt-Ulms, Gerold, St. George-Hyslop, Peter, Fraser, Paul E.
Publicado 2009

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains

por Vaillant-Beuchot, Loan, Mary, Arnaud, Pardossi-Piquard, Raphaëlle, Bourgeois, Alexandre, Lauritzen, Inger, Eysert, Fanny, Kinoshita, Paula Fernanda, Cazareth, Julie, Badot, Céline, Fragaki, Konstantina, Bussiere, Renaud, Martin, Cécile, Mary, Rosanna, Bauer, Charlotte, Pagnotta, Sophie, Paquis-Flucklinger, Véronique, Buée-Scherrer, Valérie, Buée, Luc, Lacas-Gervais, Sandra, Checler, Frédéric, Chami, Mounia
Publicado 2020