Distinct Spatial Ca(2+) Signatures Selectively Activate Different NFAT Transcription Factor Isoforms

por Kar, Pulak, Parekh, Anant B.
Publicado 2015

Ca(2+) Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors

por Alswied, Abdullah, Parekh, Anant B.
Publicado 2015

Store-operated Ca(2+) channels in airway epithelial cell function and implications for asthma

por Samanta, Krishna, Parekh, Anant B.
Publicado 2016

Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca(2+) Oscillations, Store-Operated Ca(2+) Entry and Ca(2+)-Dependent Gene Expression in Response to Receptor Stimulation

por Samanta, Krishna, Douglas, Sophie, Parekh, Anant B.
Publicado 2014

Key Role for Store-Operated Ca(2+) Channels in Activating Gene Expression in Human Airway Bronchial Epithelial Cells

por Samanta, Krishna, Bakowski, Daniel, Parekh, Anant B.
Publicado 2014

Sequential forward and reverse transport of the Na(+) Ca(2+) exchanger generates Ca(2+) oscillations within mitochondria

por Samanta, Krishna, Mirams, Gary R., Parekh, Anant B.
Publicado 2018

Caveolin-1 Alters the Pattern of Cytoplasmic Ca(2+) Oscillations and Ca(2+)-dependent Gene Expression by Enhancing Leukotriene Receptor Desensitization

por Yeh, Yi-Chun, Tang, Ming-Jer, Parekh, Anant B.
Publicado 2014

The whole‐cell Ca(2+) release‐activated Ca(2+) current, I (CRAC), is regulated by the mitochondrial Ca(2+) uniporter channel and is independent of extracellular and cytosolic Na(+)...

por Samanta, Krishna, Bakowski, Daniel, Amin, Nader, Parekh, Anant B.
Publicado 2019

Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression

por Samanta, Krishna, Kar, Pulak, Mirams, Gary R., Parekh, Anant B.
Publicado 2015

Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca(2+) Signals

por Kar, Pulak, Mirams, Gary R., Christian, Helen C., Parekh, Anant B.
Publicado 2016

Selective recruitment of different Ca(2+)-dependent transcription factors by STIM1-Orai1 channel clusters

por Lin, Yu-Ping, Bakowski, Daniel, Mirams, Gary R., Parekh, Anant B.
Publicado 2019

Single-nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression

por Yeh, Yi-Chun, Lin, Yu-Ping, Kramer, Holger, Parekh, Anant B
Publicado 2020

Dynamic Assembly of a Membrane Signaling Complex Enables Selective Activation of NFAT by Orai1

por Kar, Pulak, Samanta, Krishna, Kramer, Holger, Morris, Otto, Bakowski, Daniel, Parekh, Anant B.
Publicado 2014

Cysteinyl leukotriene type I receptor desensitization sustains Ca(2+)-dependent gene expression

por Ng, Siaw-Wei, Bakowski, Daniel, Nelson, Charmaine, Mehta, Ravi, Almeyda, Robert, Bates, Grant, Parekh, Anant B.
Publicado 2012

The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca(2+) entry

por Kar, Pulak, Lin, Yu-Ping, Bhardwaj, Rajesh, Tucker, Charles J., Bird, Gary S., Hediger, Matthias A., Monico, Carina, Amin, Nader, Parekh, Anant B.
Publicado 2021

AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca(2+) Channels

por Kar, Pulak, Barak, Pradeep, Zerio, Anna, Lin, Yu-Ping, Parekh, Amy J, Watts, Val J, Cooper, Dermot M F, Zaccolo, Manuela, Kramer, Holger, Parekh, Anant B
Publicado 2021

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation

por Grieve, Adam G., Yeh, Yi-Chun, Chang, Yu-Fen, Huang, Hsin-Yi, Zarcone, Lucrezia, Breuning, Johannes, Johnson, Nicholas, Stříšovský, Kvido, Brown, Marion H., Parekh, Anant B., Freeman, Matthew
Publicado 2021