New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity

por Pirmohamed, Munir, Ostrov, David A., Park, B. Kevin
Publicado 2015

Parsing interindividual drug variability: an emerging role for systems pharmacology

por Turner, Richard M, Park, B Kevin, Pirmohamed, Munir
Publicado 2015

Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress

por Mutter, Fiona E., Park, B. Kevin, Copple, Ian M.
Publicado 2015

Characterization of primary human T-cell responses to p-phenylenediamine and Bandrowski's base

por Gibson, Andrew, Seung-Hyun, Kim, Faulkner, Lee, Park, B Kevin, Naisbitt, Dean J
Publicado 2014

Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity

por Antoine, Daniel James, Williams, Dominic P., Kipar, Anja, Laverty, Hugh, Park, B. Kevin
Publicado 2020

Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity

por Antoine, Daniel James, Williams, Dominic P., Kipar, Anja, Laverty, Hugh, Park, B. Kevin
Publicado 2020

Detection of interleukin-22 secreting T-cells in piperacillin hypersensitive patients with cystic fibrosis

por Sullivan, Andrew, Wang, Eryi, Farrell, John, Whitaker, Paul, Peckham, Daniel, Park, B Kevin, Naisbitt, Dean
Publicado 2014

A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction

por Sharkey, Jack, Ressel, Lorenzo, Brillant, Nathalie, Scarfe, Lauren, Wilm, Bettina, Park, B. Kevin, Murray, Patricia
Publicado 2019

Stem cell models as an in vitro model for predictive toxicology

por Lynch, Stephen, Pridgeon, Chris S., Duckworth, Carrie A., Sharma, Parveen, Park, B. Kevin, Goldring, Chris E.P.
Publicado 2019

Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells

por Penman, Sophie L., Sharma, Parveen, Aerts, Hélène, Park, B. Kevin, Weaver, Richard J., Chadwick, Amy E.
Publicado 2019

Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB()

por Chia, Alvin J.L., Goldring, Christopher E., Kitteringham, Neil R., Wong, Shi Quan, Morgan, Paul, Park, B. Kevin
Publicado 2010

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01

por Ogese, Monday O, Lister, Adam, Gardner, Joshua, Meng, Xiaoli, Alfirevic, Ana, Pirmohamed, Munir, Park, B Kevin, Naisbitt, Dean J
Publicado 2021

Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis

por Amali, Mohammed, Sullivan, Andrew, Farrell, John, Meng, Xaoli, Jenkins, Roz, Whitaker, Paul, Peckham, Daniel, Park, B Kevin, Naisbitt, Dean J
Publicado 2014

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

por Forootan, Shiva S., Mutter, Fiona E., Kipar, Anja, Iwawaki, Takao, Francis, Ben, Goldring, Christopher E., Park, B. Kevin, Copple, Ian M.
Publicado 2017

Negative regulation by Programmed Death Ligand-1 during drug-specific priming of T-cells and the influence of Programmed Death-1 on effector T-cell function

por Gibson, Andrew, Ogese, Monday, Sullivan, Andrew, Wang, Eryi, Saide, Katy, Whitaker, Paul, Peckham, Daniel, Faulkner, Lee, Park, B Kevin, Naisbitt, Dean J
Publicado 2014

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine

por Yip, Vincent L.M., Pertinez, Henry, Meng, Xiaoli, Maggs, James L., Carr, Daniel F., Park, B. Kevin, Marson, Anthony G., Pirmohamed, Munir
Publicado 2020

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

por Copple, Ian M., Lister, Adam, Obeng, Akua D., Kitteringham, Neil R., Jenkins, Rosalind E., Layfield, Robert, Foster, Brian J., Goldring, Christopher E., Park, B. Kevin
Publicado 2010

Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study

por McWilliam, Stephen J., Antoine, Daniel J., Sabbisetti, Venkata, Turner, Mark A., Farragher, Tracey, Bonventre, Joseph V., Park, B. Kevin, Smyth, Rosalind L., Pirmohamed, Munir
Publicado 2012

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

por Dragovic, Sanja, Vermeulen, Nico P. E., Gerets, Helga H., Hewitt, Philip G., Ingelman‐Sundberg, Magnus, Park, B. Kevin, Juhila, Satu, Snoeys, Jan, Weaver, Richard J.
Publicado 2016

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

por Copple, Ian M., Shelton, Luke M., Walsh, Joanne, Kratschmar, Denise V., Lister, Adam, Odermatt, Alex, Goldring, Christopher E., Dinkova-Kostova, Albena T., Honda, Tadashi, Park, B. Kevin
Publicado 2014