cGAS–STING signalling in cancer: striking a balance with chromosomal instability

por Beernaert, Bruno, Parkes, Eileen E.
Publicado 2023

DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy

por Gilmore, Elaine, McCabe, Nuala, Kennedy, Richard D., Parkes, Eileen E.
Publicado 2019

Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application

por Lightbody, Gaye, Haberland, Valeriia, Browne, Fiona, Taggart, Laura, Zheng, Huiru, Parkes, Eileen, Blayney, Jaine K
Publicado 2019

Reactivation of low avidity tumor-specific CD8(+) T cells associates with immunotherapeutic efficacy of anti-PD-1

por Sugiyarto, Gessa, Lau, Doreen, Hill, Samuel Luke, Arcia-Anaya, David, Boulanger, Denise S M, Parkes, Eileen E, James, Edward, Elliott, Tim
Publicado 2023

A BRCA1 deficient, NFκB driven immune signal predicts good outcome in triple negative breast cancer

por Buckley, Niamh E., Haddock, Paula, De Matos Simoes, Ricardo, Parkes, Eileen, Irwin, Gareth, Emmert-Streib, Frank, McQuaid, Stephen, Kennedy, Richard, Mullan, Paul
Publicado 2016

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

por McCain, R. Stephen, McManus, Damian T., McQuaid, Stephen, James, Jacqueline A., Salto-Tellez, Manuel, Reid, Nathan B., Craig, Stephanie, Chisambo, Chintapuza, Bingham, Victoria, McCarron, Eamon, Parkes, Eileen, Turkington, Richard C., Coleman, Helen G.
Publicado 2019

Circulating biomarkers and outcomes from a randomised phase 2 trial of gemcitabine versus capecitabine-based chemoradiotherapy for pancreatic cancer

por Willenbrock, Frances, Cox, Catrin M., Parkes, Eileen E., Wilhelm-Benartzi, Charlotte S., Abraham, Aswin G., Owens, Robert, Sabbagh, Ahmad, Jones, Christopher M., Hughes, Daniel L. I., Maughan, Tim, Hurt, Christopher N., O’Neill, Eric E., Mukherjee, Somnath
Publicado 2020

The clinical and molecular significance associated with STING signaling in breast cancer

por Parkes, Eileen E., Humphries, Matthew P., Gilmore, Elaine, Sidi, Fatima A., Bingham, Victoria, Phyu, Su M., Craig, Stephanie, Graham, Catherine, Miller, Joseph, Griffin, Daryl, Salto-Tellez, Manuel, Madden, Stephen F., Kennedy, Richard D., Bakhoum, Samuel F., McQuaid, Stephen, Buckley, Niamh E.
Publicado 2021

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

por Parkes, Eileen E., Walker, Steven M., Taggart, Laura E., McCabe, Nuala, Knight, Laura A., Wilkinson, Richard, McCloskey, Karen D., Buckley, Niamh E., Savage, Kienan I., Salto-Tellez, Manuel, McQuaid, Stephen, Harte, Mary T., Mullan, Paul B., Harkin, D. Paul, Kennedy, Richard D.
Publicado 2016

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer

por Humphries, Matthew P., Hynes, Sean, Bingham, Victoria, Cougot, Delphine, James, Jacqueline, Patel-Socha, Farah, Parkes, Eileen E., Blayney, Jaine K., O'Rorke, Michael A., Irwin, Gareth W., McArt, Darragh G., Kennedy, Richard D., Mullan, Paul B., McQuaid, Stephen, Salto-Tellez, Manuel, Buckley, Niamh E.
Publicado 2018

Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model

por Philippou, Yiannis, Sjoberg, Hanna T., Murphy, Emma, Alyacoubi, Said, Jones, Keaton I., Gordon-Weeks, Alex N., Phyu, Su, Parkes, Eileen E., Gillies McKenna, W., Lamb, Alastair D., Gileadi, Uzi, Cerundolo, Vincenzo, Scheiblin, David A., Lockett, Stephen J., Wink, David A., Mills, Ian G., Hamdy, Freddie C., Muschel, Ruth J., Bryant, Richard J.
Publicado 2020

Non-cell-autonomous cancer progression from chromosomal instability

por Li, Jun, Hubisz, Melissa J., Earlie, Ethan M., Duran, Mercedes A., Hong, Christy, Varela, Austin A., Lettera, Emanuele, Deyell, Matthew, Tavora, Bernardo, Havel, Jonathan J., Phyu, Su M., Amin, Amit Dipak, Budre, Karolina, Kamiya, Erina, Cavallo, Julie-Ann, Garris, Christopher, Powell, Simon, Reis-Filho, Jorge S., Wen, Hannah, Bettigole, Sarah, Khan, Atif J., Izar, Benjamin, Parkes, Eileen E., Laughney, Ashley M., Bakhoum, Samuel F.
Publicado 2023

Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer

por Parkes, Eileen E., Savage, Kienan I., Lioe, Tong, Boyd, Clinton, Halliday, Sophia, Walker, Steven M., Lowry, Keith, Knight, Laura, Buckley, Niamh E., Grogan, Andrena, Logan, Gemma E., Clayton, Alison, Hurwitz, Jane, Kirk, Stephen J., Xu, Jiamei, Sidi, Fatima Abdullahi, Humphries, Matthew P., Bingham, Victoria, James, Jaqueline A., James, Colin R., Paul Harkin, D., Kennedy, Richard D., McIntosh, Stuart A.
Publicado 2021

Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma

por Turkington, Richard C, Knight, Laura A, Blayney, Jaine K, Secrier, Maria, Douglas, Rosalie, Parkes, Eileen E, Sutton, Eilis K, Stevenson, Leanne, McManus, Damian, Halliday, Sophia, McCavigan, Andrena M, Logan, Gemma E, Walker, Steven M, Steele, Christopher J, Perner, Juliane, Bornschein, Jan, MacRae, Shona, Miremadi, Ahmad, McCarron, Eamon, McQuaid, Stephen, Arthur, Kenneth, James, Jacqueline A, Eatock, Martin M, O’Neill, Robert, Noble, Fergus, Underwood, Timothy J, Harkin, D Paul, Salto-Tellez, Manuel, Fitzgerald, Rebecca C, Kennedy, Richard D
Publicado 2019

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

por Pencik, Jan, Philippe, Cecile, Schlederer, Michaela, Atas, Emine, Pecoraro, Matteo, Grund-Gröschke, Sandra, Li, Wen (Jess), Tracz, Amanda, Heidegger, Isabel, Lagger, Sabine, Trachtová, Karolína, Oberhuber, Monika, Heitzer, Ellen, Aksoy, Osman, Neubauer, Heidi A., Wingelhofer, Bettina, Orlova, Anna, Witzeneder, Nadine, Dillinger, Thomas, Redl, Elisa, Greiner, Georg, D’Andrea, David, Östman, Johnny R., Tangermann, Simone, Hermanova, Ivana, Schäfer, Georg, Sternberg, Felix, Pohl, Elena E., Sternberg, Christina, Varady, Adam, Horvath, Jaqueline, Stoiber, Dagmar, Malcolm, Tim I., Turner, Suzanne D., Parkes, Eileen E., Hantusch, Brigitte, Egger, Gerda, Rose-John, Stefan, Poli, Valeria, Jain, Suneil, Armstrong, Chris W. D., Hoermann, Gregor, Goffin, Vincent, Aberger, Fritz, Moriggl, Richard, Carracedo, Arkaitz, McKinney, Cathal, Kennedy, Richard D., Klocker, Helmut, Speicher, Michael R., Tang, Dean G., Moazzami, Ali A., Heery, David M., Hacker, Marcus, Kenner, Lukas
Publicado 2023