Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

por Pointon, Amy V., Walker, Tracy M., Phillips, Kate M., Luo, Jinli, Riley, Joan, Zhang, Shu-Dong, Parry, Joel D., Lyon, Jonathan J., Marczylo, Emma L., Gant, Timothy W.
Publicado 2010

Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs

por Kamola, Piotr J., Maratou, Klio, Wilson, Paul A., Rush, Kay, Mullaney, Tanya, McKevitt, Tom, Evans, Paula, Ridings, Jim, Chowdhury, Probash, Roulois, Aude, Fairchild, Ann, McCawley, Sean, Cartwright, Karen, Gooderham, Nigel J., Gant, Timothy W., Moores, Kitty, Hughes, Stephen A., Edbrooke, Mark R., Clark, Kenneth, Parry, Joel D.
Publicado 2017

In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization

por Kamola, Piotr J., Kitson, Jeremy D. A., Turner, Gemma, Maratou, Klio, Eriksson, Sofie, Panjwani, Aliza, Warnock, Linda C., Douillard Guilloux, Gaelle A., Moores, Kitty, Koppe, Emma L., Wixted, William E., Wilson, Paul A., Gooderham, Nigel J., Gant, Timothy W., Clark, Kenneth L., Hughes, Stephen A., Edbrooke, Mark R., Parry, Joel D.
Publicado 2015

Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis

por Clark, Kenneth L, Hughes, Stephen A, Bulsara, Pallav, Coates, Jill, Moores, Kitty, Parry, Joel, Carr, Michael, Mayer, Ruth J, Wilson, Paul, Gruenloh, Chris, Levin, Daren, Darton, Jill, Weber, Wolf-Michael, Sobczak, Katja, Gill, Deborah R, Hyde, Stephen C, Davies, Lee A, Pringle, Ian A, Sumner-Jones, Stephanie G, Jadhav, Vasant, Jamison, Sharon, Strapps, Walter R, Pickering, Victoria, Edbrooke, Mark R
Publicado 2013