The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors

por Kannan, Srinivasaraghavan, Partridge, Anthony W., Lane, David P., Verma, Chandra S.
Publicado 2019

Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology

por Garrigou, Michael, Sauvagnat, Bérengère, Duggal, Ruchia, Boo, Nicole, Gopal, Pooja, Johnston, Jennifer M., Partridge, Anthony, Sawyer, Tomi, Biswas, Kaustav, Boyer, Nicolas
Publicado 2022

Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides

por Diller, David J., Swanson, Jon, Bayden, Alexander S., Brown, Chris J., Thean, Dawn, Lane, David P., Partridge, Anthony W., Sawyer, Tomi K., Audie, Joseph
Publicado 2019

Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States

por Lim, Shuhui, Khoo, Regina, Juang, Yu-Chi, Gopal, Pooja, Zhang, Huibin, Yeo, Constance, Peh, Khong Ming, Teo, Jinkai, Ng, Simon, Henry, Brian, Partridge, Anthony W.
Publicado 2020

Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes

por Lyn, Rodney K., Singaravelu, Ragunath, Kargman, Stacia, O'Hara, Shifawn, Chan, Helen, Oballa, Renata, Huang, Zheng, Jones, Daniel M., Ridsdale, Andrew, Russell, Rodney S., Partridge, Anthony W., Pezacki, John Paul
Publicado 2014

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles

por Yuen, Tsz Ying, Brown, Christopher J., Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J., Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W., Verma, Chandra S., Lane, David P., Johannes, Charles W.
Publicado 2019

STUB1 is an intracellular checkpoint for interferon gamma sensing

por Ng, Simon, Lim, Shuhui, Sim, Adrian Chong Nyi, Mangadu, Ruban, Lau, Ally, Zhang, Chunsheng, Martinez, Sarah Bollinger, Chandramohan, Arun, Lim, U-Ming, Ho, Samantha Shu Wen, Chang, Shih Chieh, Gopal, Pooja, Hong, Lewis Z., Schwaid, Adam, Fernandis, Aaron Zefrin, Loboda, Andrey, Li, Cai, Phan, Uyen, Henry, Brian, Partridge, Anthony W.
Publicado 2022

A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays

por Kasper, Stephen H., Otten, Stephanie, Squadroni, Brian, Orr‐Terry, Cionna, Kuang, Yi, Mussallem, Lily, Ge, Lan, Yan, Lin, Kannan, Srinivasaraghavan, Verma, Chandra S., Brown, Christopher J., Johannes, Charles W., Lane, David P., Chandramohan, Arun, Partridge, Anthony W., Roberts, Lee R., Josien, Hubert, Therien, Alex G., Hett, Erik C., Howell, Bonnie J., Peier, Andrea, Ai, Xi, Cassaday, Jason
Publicado 2023

Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties

por Partridge, Anthony W., Kaan, Hung Yi Kristal, Juang, Yu-Chi, Sadruddin, Ahmad, Lim, Shuhui, Brown, Christopher J., Ng, Simon, Thean, Dawn, Ferrer, Fernando, Johannes, Charles, Yuen, Tsz Ying, Kannan, Srinivasaraghavan, Aronica, Pietro, Tan, Yaw Sing, Pradhan, Mohan R., Verma, Chandra S., Hochman, Jerome, Chen, Shiying, Wan, Hui, Ha, Sookhee, Sherborne, Brad, Lane, David P., Sawyer, Tomi K.
Publicado 2019

Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability

por Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J., Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J., Johannes, Charles W., Henry, Brian, Lane, David P., Sawyer, Tomi K., Verma, Chandra S., Partridge, Anthony W.
Publicado 2020

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

por Lim, Shuhui, Boyer, Nicolas, Boo, Nicole, Huang, Chunhui, Venkatachalam, Gireedhar, Angela Juang, Yu-Chi, Garrigou, Michael, Kaan, Hung Yi Kristal, Duggal, Ruchia, Peh, Khong Ming, Sadruddin, Ahmad, Gopal, Pooja, Yuen, Tsz Ying, Ng, Simon, Kannan, Srinivasaraghavan, Brown, Christopher J., Verma, Chandra S., Orth, Peter, Peier, Andrea, Ge, Lan, Yu, Xiang, Bhatt, Bhavana, Chen, Feifei, Wang, Erjia, Li, Nianyu Jason, Gonzales, Raymond J., Stoeck, Alexander, Henry, Brian, Sawyer, Tomi K., Lane, David P., Johannes, Charles W., Biswas, Kaustav, Partridge, Anthony W.
Publicado 2021