PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

por Riccio, Amanda A., Cingolani, Gino, Pascal, John M.
Publicado 2016

Signal-induced PARP1-Erk synergism mediates IEG expression

por Cohen-Armon, Malka, Yeheskel, Adva, Pascal, John M.
Publicado 2019

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

por Langelier, Marie-France, Riccio, Amanda A., Pascal, John M.
Publicado 2014

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

por Langelier, Marie-France, Lin, Xiaohui, Zha, Shan, Pascal, John M.
Publicado 2023

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

por Karlberg, Tobias, Langelier, Marie-France, Pascal, John M., Schüler, Herwig
Publicado 2013

Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

por Steffen, Jamin D., McCauley, Michael M., Pascal, John M.
Publicado 2016

Structural Implications for Selective Targeting of PARPs

por Steffen, Jamin D., Brody, Jonathan R., Armen, Roger S., Pascal, John M.
Publicado 2013

Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels

por Zhang, Miao, Pascal, John M., Schumann, Marcel, Armen, Roger S., Zhang, Ji-fang
Publicado 2012

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

por Langelier, Marie-France, Billur, Ramya, Sverzhinsky, Aleksandr, Black, Ben E., Pascal, John M.
Publicado 2021

NAD(+) analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

por Langelier, Marie-France, Zandarashvili, Levani, Aguiar, Pedro M., Black, Ben E., Pascal, John M.
Publicado 2018

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

por Rashid, Ishtiaque, Hammel, Michal, Sverzhinsky, Aleksandr, Tsai, Miaw-Sheue, Pascal, John M., Tainer, John A., Tomkinson, Alan E.
Publicado 2021

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

por Shao, Zhengping, Lee, Brian J, Rouleau-Turcotte, Élise, Langelier, Marie-France, Lin, Xiaohui, Estes, Verna M, Pascal, John M, Zha, Shan
Publicado 2020

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

por Eustermann, Sebastian, Wu, Wing-Fung, Langelier, Marie-France, Yang, Ji-Chun, Easton, Laura E., Riccio, Amanda A., Pascal, John M., Neuhaus, David
Publicado 2015

A two-step mechanism governing PARP1-DNA retention by PARP inhibitors

por Xue, Huijun, Bhardwaj, Amit, Yin, Yandong, Fijen, Carel, Ephstein, Anastasiya, Zhang, Lianglin, Ding, Xia, Pascal, John M., VanArsdale, Todd L., Rothenberg, Eli
Publicado 2022

Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose)

por Kuttiyatveetil, Jijin R.A., Soufari, Heddy, Dasovich, Morgan, Uribe, Isabel R., Mirhasan, Manija, Cheng, Shang-Jung, Leung, Anthony K.L., Pascal, John M.
Publicado 2022

An atypical BRCT–BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex

por Hammel, Michal, Rashid, Ishtiaque, Sverzhinsky, Aleksandr, Pourfarjam, Yasin, Tsai, Miaw-Sheue, Ellenberger, Tom, Pascal, John M, Kim, In-Kwon, Tainer, John A, Tomkinson, Alan E
Publicado 2020

Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymera...

por Patel, Maulik R., Bhatt, Aaditya, Steffen, Jamin D., Chergui, Adel, Murai, Junko, Pommier, Yves, Pascal, John M., Trombetta, Louis D., Fronczek, Frank R., Talele, Tanaji T.
Publicado 2014

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

por Sun, Yilun, Chen, Jiji, Huang, Shar-yin N., Su, Yijun P., Wang, Wenjie, Agama, Keli, Saha, Sourav, Jenkins, Lisa M., Pascal, John M., Pommier, Yves
Publicado 2021

Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro

por Kotova, Elena Y., Hsieh, Fu-Kai, Chang, Han-Wen, Maluchenko, Natalia V., Langelier, Marie-France, Pascal, John M., Luse, Donal S., Feofanov, Alexey V., Studitsky, Vasily M.
Publicado 2022

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

por Ogden, Tom E H, Yang, Ji-Chun, Schimpl, Marianne, Easton, Laura E, Underwood, Elizabeth, Rawlins, Philip B, McCauley, Michael M, Langelier, Marie-France, Pascal, John M, Embrey, Kevin J, Neuhaus, David
Publicado 2021