Comparison of the aggregation of homologous β(2)-microglobulin variants reveals protein solubility as a key determinant of amyloid formation

por Pashley, Clare L., Hewitt, Eric W., Radford, Sheena E.
Publicado 2016

Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry

por Leney, Aneika C., Pashley, Clare L., Scarff, Charlotte A., Radford, Sheena E., Ashcroft, Alison E.
Publicado 2014

Conformational Properties of the Unfolded State of Im7 in Nondenaturing Conditions

por Pashley, Clare L., Morgan, Gareth J., Kalverda, Arnout P., Thompson, Gary S., Kleanthous, Colin, Radford, Sheena E.
Publicado 2012

A Population Shift between Sparsely Populated Folding Intermediates Determines Amyloidogenicity

por Karamanos, Theodoros K., Pashley, Clare L., Kalverda, Arnout P., Thompson, Gary S., Mayzel, Maxim, Orekhov, Vladislav Y., Radford, Sheena E.
Publicado 2016

Secondary Structure in the Core of Amyloid Fibrils Formed from Human β(2)m and its Truncated Variant ΔN6

por Su, Yongchao, Sarell, Claire J., Eddy, Matthew T., Debelouchina, Galia T., Andreas, Loren B., Pashley, Clare L., Radford, Sheena E., Griffin, Robert G.
Publicado 2014

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

por Dobson, Claire L., Devine, Paul W. A., Phillips, Jonathan J., Higazi, Daniel R., Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F., Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K., Pashley, Clare L., Iadanza, Matthew G., Ranson, Neil A., Ashcroft, Alison E., Kippen, Alistair D., Vaughan, Tristan J., Radford, Sheena E., Lowe, David C.
Publicado 2016