Case Report of a 63-Year-Old Patient With Alzheimer Disease and a Novel Presenilin 2 Mutation

por Wells, Jennie L., Pasternak, Stephen H.
Publicado 2019

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid

por Tam, Joshua HK, Seah, Claudia, Pasternak, Stephen H
Publicado 2014

Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT

por Cuddy, Leah K., Seah, Claudia, Pasternak, Stephen H., Rylett, R. Jane
Publicado 2017

Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway

por Tam, Joshua H. K., Cobb, M. Rebecca, Seah, Claudia, Pasternak, Stephen H.
Publicado 2016

Population Geography and Emergency Contraception Access in Louisiana

por Chiccarelli, Elvira, Khorsandi, Nikka, Dumas, S. Amanda, Aden, James K., Pasternak, Ryan H.
Publicado 2020

The psychophysiology of guilt in healthy adults

por Stewart, Chloe A., Mitchell, Derek G.V., MacDonald, Penny A., Pasternak, Stephen H., Tremblay, Paul F., Finger, Elizabeth
Publicado 2023

Post-mortem 7 Tesla MRI detection of white matter hyperintensities: A multidisciplinary voxel-wise comparison of imaging and histological correlates

por Roseborough, Austyn D., Langdon, Kristopher D., Hammond, Robert, Cipriano, Lauren E., Pasternak, Stephen H., Whitehead, Shawn N., Khan, Ali R.
Publicado 2020

Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model

por Roseborough, A. D., Myers, S. J., Khazaee, R., Zhu, Y., Zhao, L., Iorio, E., Elahi, F. M., Pasternak, S. H., Whitehead, S. N.
Publicado 2023

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

por Tang, Weihao, Tam, Joshua H.K., Seah, Claudia, Chiu, Justin, Tyrer, Andrea, Cregan, Sean P., Meakin, Susan O., Pasternak, Stephen H.
Publicado 2015

Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway

por Lorenzen, Angela, Samosh, Jonathan, Vandewark, Kenneth, Anborgh, Pieter H, Seah, Claudia, Magalhaes, Ana C, Cregan, Sean P, Ferguson, Stephen SG, Pasternak, Stephen H
Publicado 2010

Microvessel stenosis, enlarged perivascular spaces, and fibrinogen deposition are associated with ischemic periventricular white matter hyperintensities

por Roseborough, Austyn D., Rasheed, Berk, Jung, Youngkyung, Nishimura, Kevin, Pinsky, William, Langdon, Kristopher D., Hammond, Robert, Pasternak, Stephen H., Khan, Ali R., Whitehead, Shawn N.
Publicado 2021

Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease

por Lackie, Rachel E., Marques-Lopes, Jose, Ostapchenko, Valeriy G., Good, Sarah, Choy, Wing-Yiu, van Oosten-Hawle, Patricija, Pasternak, Stephen H., Prado, Vania F., Prado, Marco A. M.
Publicado 2020

MIiSR: Molecular Interactions in Super-Resolution Imaging Enables the Analysis of Protein Interactions, Dynamics and Formation of Multi-protein Structures

por Caetano, Fabiana A., Dirk, Brennan S., Tam, Joshua H. K., Cavanagh, P. Craig, Goiko, Maria, Ferguson, Stephen S. G., Pasternak, Stephen H., Dikeakos, Jimmy D., de Bruyn, John R., Heit, Bryan
Publicado 2015

Detection of Active Caspase-3 in Mouse Models of Stroke and Alzheimer's Disease with a Novel Dual Positron Emission Tomography/Fluorescent Tracer [(68)Ga]Ga-TC3-OGDOTA

por Ostapchenko, Valeriy G., Snir, Jonatan, Suchy, Mojmir, Fan, Jue, Cobb, M. Rebecca, Chronik, Blaine A., Kovacs, Michael, Prado, Vania F., Hudson, Robert H. E., Pasternak, Stephen H., Prado, Marco A. M., Bartha, Robert
Publicado 2019

Ambroxol as a novel disease-modifying treatment for Parkinson’s disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial

por Silveira, C. R. A., MacKinley, J., Coleman, K., Li, Z., Finger, E., Bartha, R., Morrow, S. A., Wells, J., Borrie, M., Tirona, R. G., Rupar, C. A., Zou, G., Hegele, R. A., Mahuran, D., MacDonald, P., Jenkins, M. E., Jog, M., Pasternak, S. H.
Publicado 2019

Structural Brain Magnetic Resonance Imaging to Rule Out Comorbid Pathology in the Assessment of Alzheimer’s Disease Dementia: Findings from the Ontario Neurodegenerative Disease Re...

por Kapoor, Arunima, Bartha, Robert, Black, Sandra E., Borrie, Michael, Freedman, Morris, Gao, Fuqiang, Herrmann, Nathan, Mandzia, Jennifer, Ozzoude, Miracle, Ramirez, Joel, Scott, Christopher J.M., Symons, Sean, Fischer, Corinne E., Frank, Andrew, Seitz, Dallas, Wolf, Michael Uri, Verhoeff, Nicolaas Paul L.G., Naglie, Gary, Reichman, William, Masellis, Mario, Mitchell, Sara B., Tang-Wai, David F., Tartaglia, Maria Carmela, Kumar, Sanjeev, Pollock, Bruce G., Rajji, Tarek K., Finger, Elizabeth, Pasternak, Stephen H., Swartz, Richard H.
Publicado 2020

Targeted copy number variant identification across the neurodegenerative disease spectrum

por Dilliott, Allison A., Zhang, Kristina K., Wang, Jian, Abrahao, Agessandro, Binns, Malcolm A., Black, Sandra E., Borrie, Michael, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E., Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kumar, Sanjeev, Lang, Anthony E., Mandzia, Jennifer, Masellis, Mario, Pasternak, Stephen H., Pollock, Bruce G., Rajji, Tarek K., Rogaeva, Ekaterina, Sahlas, Demetrios J., Saposnik, Gustavo, Sato, Christine, Seitz, Dallas, Shoesmith, Christen, Steeves, Thomas D. L., Swartz, Richard H., Tan, Brian, Tang‐Wai, David F., Tartaglia, Maria C., Turnbull, John, Zinman, Lorne, Hegele, Robert A.
Publicado 2022

Contribution of rare variant associations to neurodegenerative disease presentation

por Dilliott, Allison A., Abdelhady, Abdalla, Sunderland, Kelly M., Farhan, Sali M. K., Abrahao, Agessandro, Binns, Malcolm A., Black, Sandra E., Borrie, Michael, Casaubon, Leanne K., Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E., Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kumar, Sanjeev, Kwan, Donna, Lang, Anthony E., Mandzia, Jennifer, Masellis, Mario, McIntyre, Adam D., Pasternak, Stephen H., Pollock, Bruce G., Rajji, Tarek K., Rogaeva, Ekaterina, Sahlas, Demetrios J., Saposnik, Gustavo, Sato, Christine, Seitz, Dallas, Shoesmith, Christen, Steeves, Thomas D. L., Swartz, Richard H., Tan, Brian, Tang-Wai, David F., Tartaglia, Maria C., Turnbull, John, Zinman, Lorne, Hegele, Robert A.
Publicado 2021

Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases

por Riek, Heidi C, Brien, Donald C, Coe, Brian C, Huang, Jeff, Perkins, Julia E, Yep, Rachel, McLaughlin, Paula M, Orange, Joseph B, Peltsch, Alicia J, Roberts, Angela C, Binns, Malcolm A, Lou, Wendy, Abrahao, Agessandro, Arnott, Stephen R, Beaton, Derek, Black, Sandra E, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew R, Grimes, David A, Kumar, Sanjeev, Lang, Anthony E, Lawrence-Dewar, Jane M, Mandzia, Jennifer L, Marras, Connie, Masellis, Mario, Pasternak, Stephen H, Pollock, Bruce G, Rajji, Tarek K, Sahlas, Demetrios J, Saposnik, Gustavo, Seitz, Dallas P, Shoesmith, Christen, Steeves, Thomas D L, Strother, Stephen C, Sunderland, Kelly M, Swartz, Richard H, Tan, Brian, Tang-Wai, David F, Tartaglia, Maria Carmela, Turnbull, John, Zinman, Lorne, Munoz, Douglas P
Publicado 2023