FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes

por van der Flier, Arjan, Liu, Zhan, Tan, Siyuan, Chen, Kai, Drager, Douglas, Liu, Tongyao, Patarroyo-White, Susannah, Jiang, Haiyan, Light, David R.
Publicado 2015

Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice

por Krishnamoorthy, Sriram, Liu, Tongyao, Drager, Douglas, Patarroyo-White, Susannah, Chhabra, Ekta Seth, Peters, Robert, Josephson, Neil, Lillicrap, David, Blumberg, Richard S., Pierce, Glenn F., Jiang, Haiyan
Publicado 2015

A Single Chain Variant of Factor VIII Fc Fusion Protein Retains Normal In Vivo Efficacy but Exhibits Altered In Vitro Activity

por Buyue, Yang, Liu, Tongyao, Kulman, John D., Toby, Garabet G., Kamphaus, George D., Patarroyo-White, Susannah, Lu, Qi, Reidy, Thomas J., Mei, Baisong, Jiang, Haiyan, Pierce, Glenn F., Sommer, Jurg M., Peters, Robert T.
Publicado 2014

Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates

por Milani, Michela, Canepari, Cesare, Liu, Tongyao, Biffi, Mauro, Russo, Fabio, Plati, Tiziana, Curto, Rosalia, Patarroyo-White, Susannah, Drager, Douglas, Visigalli, Ilaria, Brombin, Chiara, Albertini, Paola, Follenzi, Antonia, Ayuso, Eduard, Mueller, Christian, Annoni, Andrea, Naldini, Luigi, Cantore, Alessio
Publicado 2022