Cellular Size as a Means of Tracking mTOR Activity and Cell Fate of CD4+ T Cells upon Antigen Recognition

por Pollizzi, Kristen N., Waickman, Adam T., Patel, Chirag H., Sun, Im Hong, Powell, Jonathan D.
Publicado 2015

Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression

por Cheng, Chih-Hsien, Lee, Chen-Fang, Oh, Byoung Chol, Furtmüller, Georg J., Patel, Chirag H., Brandacher, Gerald, Powell, Jonathan D.
Publicado 2020

GOT1 regulates CD8(+) effector and memory T cell generation

por Xu, Wei, Patel, Chirag H., Zhao, Liang, Sun, Im-Hong, Oh, Min-Hee, Sun, Im-Meng, Helms, Rachel S., Wen, Jiayu, Powell, Jonathan D.
Publicado 2023

T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade

por Lee, Kyungho, Thompson, Elizabeth A., Gharaie, Sepideh, Patel, Chirag H., Kurzhagen, Johanna T., Pierorazio, Phillip M., Arend, Lois J., Thomas, Ajit G., Noel, Sanjeev, Slusher, Barbara S., Rabb, Hamid
Publicado 2023

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8 T cell differentiation

por Pollizzi, Kristen N., Sun, Im-Hong, Patel, Chirag H., Lo, Ying-Chun, Oh, Min-Hee, Waickman, Adam T., Tam, Ada J., Blosser, Richard L., Wen, Jiayu, Delgoffe, Greg M., Powell, Jonathan D.
Publicado 2016

The AGC kinase serum- and glucocorticoid-regulated kinase 1 (SGK1) regulates T(H)1 and T(H)2 differentiation downstream of mTORC2

por Heikamp, Emily B., Patel, Chirag H., Collins, Sam, Waickman, Adam, Oh, Min-Hee, Sun, Im-Hong, Illei, Peter, Sharma, Archna, Naray-Fejes-Toth, Aniko, Fejes-Toth, Geza, Sen, Jyoti, Horton, Maureen R., Powell, Jonathan D.
Publicado 2014

Serendipitous Discovery of T Cell–Produced KLK1b22 as a Regulator of Systemic Metabolism

por Arwood, Matthew L., Sun, Im-Hong, Patel, Chirag H., Sun, Im-Meng, Oh, Min-Hee, Bettencourt, Ian A., Claiborne, Michael D., Chan-Li, Yee, Zhao, Liang, Waickman, Adam T., Mavrothalassitis, Orestes, Wen, Jiayu, Aja, Susan, Powell, Jonathan D.
Publicado 2023

PKG-Modified TSC2 Regulates mTORC1 Activity to Counter Adverse Cardiac Stress

por Ranek, Mark J., Kokkonen-Simon, Kristen M., Chen, Anna, Dunkerly-Eyring, Brittany L., Vera, Miguel Pinilla, Oeing, Christian U., Patel, Chirag H., Nakamura, Taishi, Zhu, Guangshuo, Bedja, Djahida, Sasaki, Masayuki, Holewinski, Ronald J., Van Eyk, Jennifer E., Powell, Jonathan D., Lee, Dong Ik, Kass, David A.
Publicado 2019

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

por Baumgartner, Christina K., Ebrahimi-Nik, Hakimeh, Iracheta-Vellve, Arvin, Hamel, Keith M., Olander, Kira E., Davis, Thomas G. R., McGuire, Kathleen A., Halvorsen, Geoff T., Avila, Omar I., Patel, Chirag H., Kim, Sarah Y., Kammula, Ashwin V., Muscato, Audrey J., Halliwill, Kyle, Geda, Prasanthi, Klinge, Kelly L., Xiong, Zhaoming, Duggan, Ryan, Mu, Liang, Yeary, Mitchell D., Patti, James C., Balon, Tyler M., Mathew, Rebecca, Backus, Carey, Kennedy, Domenick E., Chen, Angeline, Longenecker, Kenton, Klahn, Joseph T., Hrusch, Cara L., Krishnan, Navasona, Hutchins, Charles W., Dunning, Jax P., Bulic, Marinka, Tiwari, Payal, Colvin, Kayla J., Chuong, Cun Lan, Kohnle, Ian C., Rees, Matthew G., Boghossian, Andrew, Ronan, Melissa, Roth, Jennifer A., Wu, Meng-Ju, Suermondt, Juliette S. M. T., Knudsen, Nelson H., Cheruiyot, Collins K., Sen, Debattama R., Griffin, Gabriel K., Golub, Todd R., El-Bardeesy, Nabeel, Decker, Joshua H., Yang, Yi, Guffroy, Magali, Fossey, Stacey, Trusk, Patricia, Sun, Im-Meng, Liu, Yue, Qiu, Wei, Sun, Qi, Paddock, Marcia N., Farney, Elliot P., Matulenko, Mark A., Beauregard, Clay, Frost, Jennifer M., Yates, Kathleen B., Kym, Philip R., Manguso, Robert T.
Publicado 2023