BRCA1 and Metastasis: Outcome of Defective DNA Repair

por Krishnan, Rehna, Patel, Parasvi S., Hakem, Razqallah
Publicado 2021

ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

por Leung, Wendy, Simoneau, Antoine, Saxena, Sneha, Jackson, Jessica, Patel, Parasvi S., Limbu, Mangsi, Vindigni, Alessandro, Zou, Lee
Publicado 2023

The RNA m5C modification in R-loops as an off switch of Alt-NHEJ

por Yang, Haibo, Lachtara, Emily M., Ran, Xiaojuan, Hopkins, Jessica, Patel, Parasvi S., Zhu, Xueping, Xiao, Yao, Phoon, Laiyee, Gao, Boya, Zou, Lee, Lawrence, Michael S., Lan, Li
Publicado 2023

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

por Guturi, Kiran Kumar Naidu, Bohgaki, Miyuki, Bohgaki, Toshiyuki, Srikumar, Tharan, Ng, Deborah, Kumareswaran, Ramya, El Ghamrasni, Samah, Jeon, Justin, Patel, Parasvi, Eldin, Mohamed Saad, Bristow, Rob, Cheung, Peter, Stewart, Grant S., Raught, Brian, Hakem, Anne, Hakem, Razqallah
Publicado 2016

Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers

por Patel, Parasvi S, Algouneh, Arash, Krishnan, Rehna, Reynolds, John J, Nixon, Kevin C J, Hao, Jun, Lee, Jihoon, Feng, Yue, Fozil, Chehronai, Stanic, Mia, Yerlici, Talya, Su, Peiran, Soares, Fraser, Liedtke, Elisabeth, Prive, Gil, Baider, Gary D, Pujana, Miquel Angel, Mekhail, Karim, He, Housheng Hansen, Hakem, Anne, Stewart, Grant S, Hakem, Razqallah
Publicado 2023

Nucleolar RNA polymerase II drives ribosome biogenesis

por Abraham, Karan J., Khosraviani, Negin, Chan, Janet N.Y., Gorthi, Aparna, Samman, Anas, Zhao, Dorothy Y., Wang, Miling, Bokros, Michael, Vidya, Elva, Ostrowski, Lauren A., Oshidari, Roxanne, Pietrobon, Violena, Patel, Parasvi, Algouneh, Arash, Singhania, Rajat, Liu, Yupeng, Yerlici, V. Talya, De Carvalho, Daniel D., Ohh, Michael, Dickson, Brendan C., Hakem, Razq, Greenblatt, Jack F., Lee, Stephen, Bishop, Alexander J. R., Mekhail, Karim
Publicado 2020

The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness

por Thomas, Geethu Emily, Egan, Grace, García-Prat, Laura, Botham, Aaron, Voisin, Veronique, Patel, Parasvi S., Hoff, Fieke W., Chin, Jordan, Nachmias, Boaz, Kaufmann, Kerstin B., Khan, Dilshad H., Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, MacLean, Neil, O’Brien, Cristiana, Singh, Rashim P., Jones, Courtney L., Harding, Shane M., Raught, Brian, Arruda, Andrea, Minden, Mark D., Bader, Gary D., Hakem, Razq, Kornblau, Steve, Dick, John E., Schimmer, Aaron D.
Publicado 2022

RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

por Krishnan, Rehna, Lapierre, Mariah, Gautreau, Brandon, Nixon, Kevin C J, El Ghamrasni, Samah, Patel, Parasvi S, Hao, Jun, Yerlici, V Talya, Guturi, Kiran Kumar Naidu, St-Germain, Jonathan, Mateo, Francesca, Saad, Amine, Algouneh, Arash, Earnshaw, Rebecca, Shili, Duan, Seitova, Alma, Miller, Joshua, Khosraviani, Negin, Penn, Adam, Ho, Brandon, Sanchez, Otto, Hande, M Prakash, Masson, Jean-Yves, Brown, Grant W, Alaoui-Jamali, Moulay, Reynolds, John J, Arrowsmith, Cheryl, Raught, Brian, Pujana, Miguel A, Mekhail, Karim, Stewart, Grant S, Hakem, Anne, Hakem, Razqallah
Publicado 2023