Design of universal Ebola virus vaccine candidates via immunofocusing

por Xu, Duo, Powell, Abigail E., Utz, Ashley, Sanyal, Mrinmoy, Do, Jonathan, Patten, J.J., Moliva, Juan I., Sullivan, Nancy J., Davey, Robert A., Kim, Peter S.
Publicado 2023

Network Medicine Framework for Identifying Drug Repurposing Opportunities for COVID-19

por Morselli Gysi, Deisy, Do Valle, Ítalo, Zitnik, Marinka, Ameli, Asher, Gan, Xiao, Varol, Onur, Ghiassian, Susan Dina, Patten, JJ, Davey, Robert, Loscalzo, Joseph, Barabási, Albert-László
Publicado 2020

Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19

por Demarest, James F., Kienle, Maryline, Boytz, RuthMabel, Ayres, Mary, Kim, Eun Jung, Patten, J.J., Chung, Donghoon, Gandhi, Varsha, Davey, Robert A., Sykes, David B., Shohdy, Nadim, Pottage, John C., Kumar, Vikram S.
Publicado 2022

Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer

por Westcott, Peter M K, Sacks, Nathan J, Schenkel, Jason M, Ely, Zackery A, Smith, Olivia, Hauck, Haley, Jaeger, Alex M, Zhang, Daniel, Backlund, Coralie M, Beytagh, Mary C, Patten, JJ, Elbashir, Ryan, Eng, George, Irvine, Darrell J, Yilmaz, Omer H, Jacks, Tyler
Publicado 2021

The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein

por Zou, Charles, Yoon, Hojong, Park, Paul M.C., Patten, J.J., Pellman, Jesse, Carreiro, Jeannie, Tsai, Jonathan M., Li, Yen-Der, Roy Burman, Shourya S., Donovan, Katherine A., Gasser, Jessica, Sperling, Adam S., Nowak, Radosław P., Fischer, Eric S., Davey, Robert A., Ebert, Benjamin L., Słabicki, Mikołaj
Publicado 2023

Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization

por Patten, J.J., Keiser, Patrick T., Morselli-Gysi, Deisy, Menichetti, Giulia, Mori, Hiroyuki, Donahue, Callie J., Gan, Xiao, Valle, Italo do, Geoghegan-Barek, Kathleen, Anantpadma, Manu, Boytz, RuthMabel, Berrigan, Jacob L., Stubbs, Sarah H., Ayazika, Tess, O’Leary, Colin, Jalloh, Sallieu, Wagner, Florence, Ayehunie, Seyoum, Elledge, Stephen J., Anderson, Deborah, Loscalzo, Joseph, Zitnik, Marinka, Gummuluru, Suryaram, Namchuk, Mark N., Barabási, Albert-László, Davey, Robert A.
Publicado 2022

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening

por Gorgulla, Christoph, Padmanabha Das, Krishna M., Leigh, Kendra E., Cespugli, Marco, Fischer, Patrick D., Wang, Zi-Fu, Tesseyre, Guilhem, Pandita, Shreya, Shnapir, Alec, Calderaio, Anthony, Gechev, Minko, Rose, Alexander, Lewis, Noam, Hutcheson, Colin, Yaffe, Erez, Luxenburg, Roni, Herce, Henry D., Durmaz, Vedat, Halazonetis, Thanos D., Fackeldey, Konstantin, Patten, J.J., Chuprina, Alexander, Dziuba, Igor, Plekhova, Alla, Moroz, Yurii, Radchenko, Dmytro, Tarkhanova, Olga, Yavnyuk, Irina, Gruber, Christian, Yust, Ryan, Payne, Dave, Näär, Anders M., Namchuk, Mark N., Davey, Robert A., Wagner, Gerhard, Kinney, Jamie, Arthanari, Haribabu
Publicado 2021

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

por Hekman, Ryan M., Hume, Adam J., Goel, Raghuveera Kumar, Abo, Kristine M., Huang, Jessie, Blum, Benjamin C., Werder, Rhiannon B., Suder, Ellen L., Paul, Indranil, Phanse, Sadhna, Youssef, Ahmed, Alysandratos, Konstantinos D., Padhorny, Dzmitry, Ojha, Sandeep, Mora-Martin, Alexandra, Kretov, Dmitry, Ash, Peter E.A., Verma, Mamta, Zhao, Jian, Patten, J.J., Villacorta-Martin, Carlos, Bolzan, Dante, Perea-Resa, Carlos, Bullitt, Esther, Hinds, Anne, Tilston-Lunel, Andrew, Varelas, Xaralabos, Farhangmehr, Shaghayegh, Braunschweig, Ulrich, Kwan, Julian H., McComb, Mark, Basu, Avik, Saeed, Mohsan, Perissi, Valentina, Burks, Eric J., Layne, Matthew D., Connor, John H., Davey, Robert, Cheng, Ji-Xin, Wolozin, Benjamin L., Blencowe, Benjamin J., Wuchty, Stefan, Lyons, Shawn M., Kozakov, Dima, Cifuentes, Daniel, Blower, Michael, Kotton, Darrell N., Wilson, Andrew A., Mühlberger, Elke, Emili, Andrew
Publicado 2020

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

por Hekman, Ryan M., Hume, Adam J., Goel, Raghuveera Kumar, Abo, Kristine M., Huang, Jessie, Blum, Benjamin C., Werder, Rhiannon B., Suder, Ellen L., Paul, Indranil, Phanse, Sadhna, Youssef, Ahmed, Alysandratos, Konstantinos D., Padhorny, Dzmitry, Ojha, Sandeep, Mora-Martin, Alexandra, Kretov, Dmitry, Ash, Peter E.A., Verma, Mamta, Zhao, Jian, Patten, J.J., Villacorta-Martin, Carlos, Bolzan, Dante, Perea-Resa, Carlos, Bullitt, Esther, Hinds, Anne, Tilston-Lunel, Andrew, Varelas, Xaralabos, Farhangmehr, Shaghayegh, Braunschweig, Ulrich, Kwan, Julian H., McComb, Mark, Basu, Avik, Saeed, Mohsan, Perissi, Valentina, Burks, Eric J., Layne, Matthew D., Connor, John H., Davey, Robert, Cheng, Ji-Xin, Wolozin, Benjamin L., Blencowe, Benjamin J., Wuchty, Stefan, Lyons, Shawn M., Kozakov, Dima, Cifuentes, Daniel, Blower, Michael, Kotton, Darrell N., Wilson, Andrew A., Mühlberger, Elke, Emili, Andrew
Publicado 2021