Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy

por Dachs, Gabi U., Hunt, Michelle A., Syddall, Sophie, Singleton, Dean C., Patterson, Adam V.
Publicado 2009

Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy

por Fu, Zhe, Mowday, Alexandra M., Smaill, Jeff B., Hermans, Ian F., Patterson, Adam V.
Publicado 2021

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

por Green, Laura K., Storey, Mathew A., Williams, Elsie M., Patterson, Adam V., Smaill, Jeff B., Copp, Janine N., Ackerley, David F.
Publicado 2013

Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling

por Jackson-Patel, Victoria, Liu, Emily, Bull, Matthew R., Ashoorzadeh, Amir, Bogle, Gib, Wolfram, Anna, Hicks, Kevin O., Smaill, Jeff B., Patterson, Adam V.
Publicado 2022

Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia

por Guise, Christopher P., Mowday, Alexandra M., Ashoorzadeh, Amir, Yuan, Ran, Lin, Wan-Hua, Wu, Dong-Hai, Smaill, Jeff B., Patterson, Adam V., Ding, Ke
Publicado 2014

Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress

por Mowday, Alexandra M., Guise, Christopher P., Ackerley, David F., Minton, Nigel P., Lambin, Philippe, Dubois, Ludwig J., Theys, Jan, Smaill, Jeff B., Patterson, Adam V.
Publicado 2016

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

por Spiegelberg, Linda, Houben, Ruud, Niemans, Raymon, de Ruysscher, Dirk, Yaromina, Ala, Theys, Jan, Guise, Christopher P., Smaill, Jeffrey B., Patterson, Adam V., Lambin, Philippe, Dubois, Ludwig J.
Publicado 2019

Pseudomonas aeruginosa NfsB and nitro-CBI-DEI – a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy

por Green, Laura K, Syddall, Sophie P, Carlin, Kendall M, Bell, Glenn D, Guise, Christopher P, Mowday, Alexandra M, Hay, Michael P, Smaill, Jeffrey B, Patterson, Adam V, Ackerley, David F
Publicado 2013

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents

por Omran, Ziad, Guise, Chris P., Chen, Linwei, Rauch, Cyril, Abdalla, Ashraf N., Abdullah, Omeima, Sindi, Ikhlas A., Fischer, Peter M., Smaill, Jeff B., Patterson, Adam V., Liu, Yuxiu, Wang, Qingmin
Publicado 2021

Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

por Ashoorzadeh, Amir, Mowday, Alexandra M., Guise, Christopher P., Silva, Shevan, Bull, Matthew R., Abbattista, Maria R., Copp, Janine N., Williams, Elsie M., Ackerley, David F., Patterson, Adam V., Smaill, Jeff B.
Publicado 2022

Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

por Guise, Chris P., Abbattista, Maria R., Anderson, Robert F., Li, Dan, Taghipouran, Rana, Tsai, Angela, Lee, Su Jung, Smaill, Jeff B., Denny, William A., Hay, Michael P., Wilson, William R., Hicks, Kevin O., Patterson, Adam V.
Publicado 2020

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3

por Abbattista, Maria R., Ashoorzadeh, Amir, Guise, Christopher P., Mowday, Alexandra M., Mittra, Rituparna, Silva, Shevan, Hicks, Kevin O., Bull, Matthew R., Jackson-Patel, Victoria, Lin, Xiaojing, Prosser, Gareth A., Lambie, Neil K., Dachs, Gabi U., Ackerley, David F., Smaill, Jeff B., Patterson, Adam V.
Publicado 2021

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

por van der Wiel, Alexander M.A., Jackson-Patel, Victoria, Niemans, Raymon, Yaromina, Ala, Liu, Emily, Marcus, Damiënne, Mowday, Alexandra M., Lieuwes, Natasja G., Biemans, Rianne, Lin, Xiaojing, Fu, Zhe, Kumara, Sisira, Jochems, Arthur, Ashoorzadeh, Amir, Anderson, Robert F., Hicks, Kevin O., Bull, Matthew R., Abbattista, Maria R., Guise, Christopher P., Deschoemaeker, Sofie, Thiolloy, Sophie, Heyerick, Arne, Solivio, Morwena J., Balbo, Silvia, Smaill, Jeff B., Theys, Jan, Dubois, Ludwig J., Patterson, Adam V., Lambin, Philippe
Publicado 2021