Advances in epigenome-wide association studies for common diseases

por Paul, Dirk S., Beck, Stephan
Publicado 2014

Functional interpretation of non-coding sequence variation: Concepts and challenges

por Paul, Dirk S, Soranzo, Nicole, Beck, Stephan
Publicado 2014

Tensorial blind source separation for improved analysis of multi-omic data

por Teschendorff, Andrew E., Jing, Han, Paul, Dirk S., Virta, Joni, Nordhausen, Klaus
Publicado 2018

Cell and tissue type independent age-associated DNA methylation changes are not rare but common

por Zhu, Tianyu, Zheng, Shijie C, Paul, Dirk S., Horvath, Steve, Teschendorff, Andrew E.
Publicado 2018

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

por Alasoo, Kaur, Rodrigues, Julia, Danesh, John, Freitag, Daniel F, Paul, Dirk S, Gaffney, Daniel J
Publicado 2019

Assessment of RainDrop BS-seq as a method for large-scale, targeted bisulfite sequencing

por Paul, Dirk S, Guilhamon, Paul, Karpathakis, Anna, Butcher, Lee M, Thirlwell, Christina, Feber, Andrew, Beck, Stephan
Publicado 2014

ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci

por Stacey, David, Fauman, Eric B, Ziemek, Daniel, Sun, Benjamin B, Harshfield, Eric L, Wood, Angela M, Butterworth, Adam S, Suhre, Karsten, Paul, Dirk S
Publicado 2019

Correlation of an epigenetic mitotic clock with cancer risk

por Yang, Zhen, Wong, Andrew, Kuh, Diana, Paul, Dirk S., Rakyan, Vardhman K., Leslie, R. David, Zheng, Shijie C., Widschwendter, Martin, Beck, Stephan, Teschendorff, Andrew E.
Publicado 2016

Maps of open chromatin highlight cell type–restricted patterns of regulatory sequence variation at hematological trait loci

por Paul, Dirk S., Albers, Cornelis A., Rendon, Augusto, Voss, Katrin, Stephens, Jonathan, van der Harst, Pim, Chambers, John C., Soranzo, Nicole, Ouwehand, Willem H., Deloukas, Panos
Publicado 2013

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

por Webster, Amy P., Plant, Darren, Ecker, Simone, Zufferey, Flore, Bell, Jordana T., Feber, Andrew, Paul, Dirk S., Beck, Stephan, Barton, Anne, Williams, Frances M. K., Worthington, Jane
Publicado 2018

PhenoScanner: a database of human genotype–phenotype associations

por Staley, James R., Blackshaw, James, Kamat, Mihir A., Ellis, Steve, Surendran, Praveen, Sun, Benjamin B., Paul, Dirk S., Freitag, Daniel, Burgess, Stephen, Danesh, John, Young, Robin, Butterworth, Adam S.
Publicado 2016

Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomics

por Guilhamon, Paul, Butcher, Lee M, Presneau, Nadege, Wilson, Gareth A, Feber, Andrew, Paul, Dirk S, Schütte, Moritz, Haybaeck, Johannes, Keilholz, Ulrich, Hoffman, Jens, Ross, Mark T, Flanagan, Adrienne M, Beck, Stephan
Publicado 2014

Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes

por Maher, Geoffrey J., Ralph, Hannah K., Ding, Zhihao, Koelling, Nils, Mlcochova, Hana, Giannoulatou, Eleni, Dhami, Pawan, Paul, Dirk S., Stricker, Stefan H., Beck, Stephan, McVean, Gilean, Wilkie, Andrew O.M., Goriely, Anne
Publicado 2018

Effects of protein-coding variants on blood metabolite measurements and clinical biomarkers in the UK Biobank

por Nag, Abhishek, Dhindsa, Ryan S., Middleton, Lawrence, Jiang, Xiao, Vitsios, Dimitrios, Wigmore, Eleanor, Allman, Erik L., Reznichenko, Anna, Carss, Keren, Smith, Katherine R., Wang, Quanli, Challis, Benjamin, Paul, Dirk S., Harper, Andrew R., Petrovski, Slavé
Publicado 2023

Genetically personalised organ-specific metabolic models in health and disease

por Foguet, Carles, Xu, Yu, Ritchie, Scott C., Lambert, Samuel A., Persyn, Elodie, Nath, Artika P., Davenport, Emma E., Roberts, David J., Paul, Dirk S., Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S., Yau, Christopher, Inouye, Michael
Publicado 2022

Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits

por Paul, Dirk S., Nisbet, James P., Yang, Tsun-Po, Meacham, Stuart, Rendon, Augusto, Hautaviita, Katta, Tallila, Jonna, White, Jacqui, Tijssen, Marloes R., Sivapalaratnam, Suthesh, Basart, Hanneke, Trip, Mieke D., Göttgens, Berthold, Soranzo, Nicole, Ouwehand, Willem H., Deloukas, Panos
Publicado 2011

Correction: Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits

por Paul, Dirk S., Nisbet, James P., Yang, Tsun-Po, Meacham, Stuart, Rendon, Augusto, Hautaviita, Katta, Tallila, Jonna, White, Jacqui, Tijssen, Marloes R., Sivapalaratnam, Suthesh, Basart, Hanneke, Trip, Mieke D., Göttgens, Berthold, Soranzo, Nicole, Ouwehand, Willem H., Deloukas, Panos
Publicado 2011

Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma

por Farahi, Neda, Paige, Ellie, Balla, Jozef, Prudence, Emily, Ferreira, Ricardo C., Southwood, Mark, Appleby, Sarah L., Bakke, Per, Gulsvik, Amund, Litonjua, Augusto A., Sparrow, David, Silverman, Edwin K., Cho, Michael H., Danesh, John, Paul, Dirk S., Freitag, Daniel F., Chilvers, Edwin R.
Publicado 2017

A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation

por Paul, Dirk S., Jones, Allison, Sellar, Rob S., Mayor, Neema P., Feber, Andrew, Webster, Amy P., Afonso, Neuza, Sergeant, Ruhena, Szydlo, Richard M., Apperley, Jane F., Widschwendter, Martin, Mackinnon, Stephen, Marsh, Steven G. E., Madrigal, J. Alejandro, Rakyan, Vardhman K., Peggs, Karl S., Beck, Stephan
Publicado 2015

Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans

por Lemmelä, Susanna, Wigmore, Eleanor M, Benner, Christian, Havulinna, Aki S, Ong, Rachel MY, Kempf, Tibor, Wollert, Kai C, Blankenberg, Stefan, Zeller, Tanja, Peters, James E, Salomaa, Veikko, Fritsch, Maria, March, Ruth, Palotie, Aarno, Daly, Mark, Butterworth, Adam S, Kinnunen, Mervi, Paul, Dirk S, Matakidou, Athena
Publicado 2022