Mitochondria at the crossroads of ATM-mediated stress signaling and regulation of reactive oxygen species

por Lee, Ji-Hoon, Paull, Tanya T.
Publicado 2020

Quantitation of DNA double-strand break resection intermediates in human cells

por Zhou, Yi, Caron, Pierre, Legube, Gaëlle, Paull, Tanya T.
Publicado 2014

Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

por Costanzo, Vincenzo, Paull, Tanya, Gottesman, Max, Gautier, Jean
Publicado 2004

Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites

por Deshpande, Rajashree A., Lee, Ji-Hoon, Paull, Tanya T.
Publicado 2017

Direct Activation of ATM by Resveratrol under Oxidizing Conditions

por Lee, Ji-Hoon, Guo, Zhi, Myler, Logan R., Zheng, Suting, Paull, Tanya T.
Publicado 2014

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

por Daniel, Jeremy A., Pellegrini, Manuela, Lee, Ji-Hoon, Paull, Tanya T., Feigenbaum, Lionel, Nussenzweig, André
Publicado 2008

Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice

por Deshpande, Rajashree A., Marin-Gonzalez, Alberto, Barnes, Hannah K., Woolley, Phillip R., Ha, Taekjip, Paull, Tanya T.
Publicado 2023

Mre11–Rad50–Xrs2 and Sae2 promote 5’ strand resection of DNA double-strand breaks

por Nicolette, Matthew L., Lee, Kihoon, Guo, Zhi, Rani, Mridula, Chow, Julia M., Lee, Sang Eun, Paull, Tanya T.
Publicado 2010

Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein

por Sarangi, Prabha, Steinacher, Roland, Altmannova, Veronika, Fu, Qiong, Paull, Tanya T., Krejci, Lumir, Whitby, Matthew C., Zhao, Xiaolan
Publicado 2015

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

por Lee, Ji-Hoon, Mand, Michael R., Deshpande, Rajashree A., Kinoshita, Eri, Yang, Soo-Hyun, Wyman, Claire, Paull, Tanya T.
Publicado 2013

EXD2 promotes homologous recombination by facilitating DNA-end resection

por Broderick, Ronan, Nieminuszczy, Jadwiga, Baddock, Hannah T., Deshpande, Rajashree, Gileadi, Opher, Paull, Tanya T., McHugh, Peter J, Niedzwiedz, Wojciech
Publicado 2016

Ancient and Recent Adaptive Evolution of Primate Non-Homologous End Joining Genes

por Demogines, Ann, East, Alysia M., Lee, Ji-Hoon, Grossman, Sharon R., Sabeti, Pardis C., Paull, Tanya T., Sawyer, Sara L.
Publicado 2010

BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination

por Hoa, Nguyen Ngoc, Kobayashi, Junya, Omura, Masato, Hirakawa, Mayumi, Yang, Soo-Hyun, Komatsu, Kenshi, Paull, Tanya T., Takeda, Shunichi, Sasanuma, Hiroyuki
Publicado 2015

DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres

por Myler, Logan R., Toia, Beatrice, Vaughan, Cara K., Takai, Kaori, Matei, Andreea M., Wu, Peng, Paull, Tanya T., de Lange, Titia, Lottersberger, Francisca
Publicado 2023

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

por Deshpande, Rajashree A., Myler, Logan R., Soniat, Michael M., Makharashvili, Nodar, Lee, Linda, Lees-Miller, Susan P., Finkelstein, Ilya J., Paull, Tanya T.
Publicado 2020

Homeodomain Proteins Directly Regulate ATM Kinase Activity

por Johnson, Tanya E., Lee, Ji-Hoon, Myler, Logan R., Zhou, Yi, Mosley, Trenell J., Yang, Soo-Hyun, Uprety, Nadima, Kim, Jonghwan, Paull, Tanya T.
Publicado 2018

Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

por Makharashvili, Nodar, Arora, Sucheta, Yin, Yizhi, Fu, Qiong, Wen, Xuemei, Lee, Ji-Hoon, Kao, Chung-Hsuan, Leung, Justin WC, Miller, Kyle M, Paull, Tanya T
Publicado 2018

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

por Paiano, Jacob, Wu, Wei, Yamada, Shintaro, Sciascia, Nicholas, Callen, Elsa, Paola Cotrim, Ana, Deshpande, Rajashree A., Maman, Yaakov, Day, Amanda, Paull, Tanya T., Nussenzweig, André
Publicado 2020

Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links

por Cheng, Wen-Hsing, Kusumoto, Rika, Opresko, Patricia L., Sui, XiuFen, Huang, Shurong, Nicolette, Matthew L., Paull, Tanya T., Campisi, Judith, Seidman, Michael, Bohr, Vilhelm A.
Publicado 2006

Loss of ATM kinase activity leads to embryonic lethality in mice

por Daniel, Jeremy A., Pellegrini, Manuela, Lee, Baeck-Seung, Guo, Zhi, Filsuf, Darius, Belkina, Natalya V., You, Zhongsheng, Paull, Tanya T., Sleckman, Barry P., Feigenbaum, Lionel, Nussenzweig, André
Publicado 2012