Catabolic Reductive Dehalogenase Substrate Complex Structures Underpin Rational Repurposing of Substrate Scope

por Halliwell, Tom, Fisher, Karl, Payne, Karl A. P., Rigby, Stephen E. J., Leys, David
Publicado 2020

Heterologous expression of cobalamin dependent class-III enzymes

por Halliwell, Tom, Fisher, Karl, Payne, Karl A.P., Rigby, Stephen E.J., Leys, David
Publicado 2021

Structural and biochemical characterization of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase

por Gahloth, Deepankar, Fisher, Karl, Payne, Karl A.P., Cliff, Matthew, Levy, Colin, Leys, David
Publicado 2022

Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding

por Beveridge, Rebecca, Migas, Lukasz G., Payne, Karl A. P., Scrutton, Nigel S., Leys, David, Barran, Perdita E.
Publicado 2016

Efficient NADPH-dependent dehalogenation afforded by a self-sufficient reductive dehalogenase

por Fisher, Karl, Halliwell, Tom, Payne, Karl A.P., Ragala, Gabriel, Hay, Sam, Rigby, Stephen E.J., Leys, David
Publicado 2023

UbiD domain dynamics underpins aromatic decarboxylation

por Marshall, Stephen A., Payne, Karl A. P., Fisher, Karl, Titchiner, Gabriel R., Levy, Colin, Hay, Sam, Leys, David
Publicado 2021

Enzymatic control of cycloadduct conformation ensures reversible 1,3 dipolar cycloaddition in a prFMN dependent decarboxylase

por Bailey, Samuel S., Payne, Karl A. P., Saaret, Annica, Marshall, Stephen A., Gostimskaya, Irina, Kosov, Iaroslav, Fisher, Karl, Hay, Sam, Leys, David
Publicado 2019

Crystal structure of X‐prolyl aminopeptidase fromCaenorhabditis elegans: A cytosolic enzyme with a di‐nuclear active site

por Iyer, Shalini, La-Borde, Penelope J., Payne, Karl A.P., Parsons, Mark R., Turner, Anthony J., Isaac, R. Elwyn, Acharya, K. Ravi
Publicado 2015

The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry

por Marshall, Stephen A., Payne, Karl A. P., Fisher, Karl, White, Mark D., Ní Cheallaigh, Aisling, Balaikaite, Arune, Rigby, Stephen E. J., Leys, David
Publicado 2019

Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification

por Payne, Karl A. P., Fisher, Karl, Sjuts, Hanno, Dunstan, Mark S., Bellina, Bruno, Johannissen, Linus, Barran, Perdita, Hay, Sam, Rigby, Stephen E. J., Leys, David
Publicado 2015

The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis

por Bailey, Samuel S., Payne, Karl A. P., Fisher, Karl, Marshall, Stephen A., Cliff, Matthew J., Spiess, Reynard, Parker, David A., Rigby, Stephen E. J., Leys, David
Publicado 2018

Terminal Alkenes from Acrylic Acid Derivatives via Non‐Oxidative Enzymatic Decarboxylation by Ferulic Acid Decarboxylases

por Aleku, Godwin A., Prause, Christoph, Bradshaw‐Allen, Ruth T., Plasch, Katharina, Glueck, Silvia M., Bailey, Samuel S., Payne, Karl A. P., Parker, David A., Faber, Kurt, Leys, David
Publicado 2018

Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)

por Payne, Karl A.P., Marshall, Stephen A., Fisher, Karl, Cliff, Matthew J., Cannas, Diego M., Yan, Cunyu, Heyes, Derren J., Parker, David A., Larrosa, Igor, Leys, David
Publicado 2019

Structure and Mechanism of Pseudomonas aeruginosa PA0254/HudA, a prFMN-Dependent Pyrrole-2-carboxylic Acid Decarboxylase Linked to Virulence

por Payne, Karl A. P., Marshall, Stephen A., Fisher, Karl, Rigby, Stephen E. J., Cliff, Matthew J., Spiess, Reynard, Cannas, Diego M., Larrosa, Igor, Hay, Sam, Leys, David
Publicado 2021

UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis

por White, Mark D., Payne, Karl A.P., Fisher, Karl, Marshall, Stephen A., Parker, David, Rattray, Nicholas J.W., Trivedi, Drupad K., Goodacre, Royston, Rigby, Stephen E.J., Scrutton, Nigel S., Hay, Sam, Leys, David
Publicado 2015

New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition

por Payne, Karl A.P., White, Mark D., Fisher, Karl, Khara, Basile, Bailey, Samuel S., Parker, David, Rattray, Nicholas J.W., Trivedi, Drupad K., Goodacre, Royston, Beveridge, Rebecca, Barran, Perdita, Rigby, Stephen E.J., Scrutton, Nigel S., Hay, Sam, Leys, David
Publicado 2015