Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity

por Tolbert, William D., Sherburn, Rebekah T., Van, Verna, Pazgier, Marzena
Publicado 2019

Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1

por Lewis, George K., Finzi, Andrés, DeVico, Anthony L., Pazgier, Marzena
Publicado 2015

Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity [ADCC] Responses

por Pollara, Justin, Bonsignori, Mattia, Moody, M. Anthony, Pazgier, Marzena, Haynes, Barton F, Ferrari, Guido
Publicado 2013

Effects of gp120 Inner Domain (ID2) Immunogen Doses on Elicitation of Anti-HIV-1 Functional Fc-Effector Response to C1/C2 (Cluster A) Epitopes in Mice

por Sherburn, Rebekah, Tolbert, William D., Gottumukkala, Suneetha, Beaudoin-Bussières, Guillaume, Finzi, Andrés, Pazgier, Marzena
Publicado 2020

Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer

por Tolbert, William D., Nguyen, Dung N., Tehrani, Zahra Rikhtegaran, Sajadi, Mohammad M., Pazgier, Marzena
Publicado 2021

Concurrent Exposure of Neutralizing and Non-neutralizing Epitopes on a Single HIV-1 Envelope Structure

por Ray, Krishanu, Mengistu, Meron, Orlandi, Chiara, Pazgier, Marzena, Lewis, George K., DeVico, Anthony L.
Publicado 2019

Stoichiometric Analyses of Soluble CD4 to Native-like HIV-1 Envelope by Single-Molecule Fluorescence Spectroscopy

por Agrawal, Parul, DeVico, Anthony L., Foulke, James S., Lewis, George K., Pazgier, Marzena, Ray, Krishanu
Publicado 2019

Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt

por Wang, Qingxia, Yang, Yilin, Luo, Gan, Zhou, Yang, Tolbert, William D., Pazgier, Marzena, Liao, Chongbing, Lu, Wuyuan
Publicado 2022

Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function

por Zhao, Le, Tolbert, W. David, Ericksen, Bryan, Zhan, Changyou, Wu, Xueji, Yuan, Weirong, Li, Xu, Pazgier, Marzena, Lu, Wuyuan
Publicado 2013

Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins

por Anand, Sai Priya, Chen, Yaozong, Prévost, Jérémie, Gasser, Romain, Beaudoin-Bussières, Guillaume, Abrams, Cameron F., Pazgier, Marzena, Finzi, Andrés
Publicado 2020

Elicitation of Cluster A and Co-Receptor Binding Site Antibodies Are Required to Eliminate HIV-1 Infected Cells

por Beaudoin-Bussières, Guillaume, Prévost, Jérémie, Gendron-Lepage, Gabrielle, Melillo, Bruno, Chen, Junhua, Smith III, Amos B., Pazgier, Marzena, Finzi, Andrés
Publicado 2020

Induction of Fc-Mediated Effector Functions Against a Stabilized Inner Domain of HIV-1 gp120 Designed to Selectively Harbor the A32 Epitope Region

por Visciano, Maria L., Gohain, Neelakshi, Sherburn, Rebekah, Orlandi, Chiara, Flinko, Robin, Dashti, Amir, Lewis, George K., Tolbert, William D., Pazgier, Marzena
Publicado 2019

Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site

por Tolbert, William D., Sherburn, Rebekah, Gohain, Neelakshi, Ding, Shilei, Flinko, Robin, Orlandi, Chiara, Ray, Krishanu, Finzi, Andrés, Lewis, George K., Pazgier, Marzena
Publicado 2020

Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological and pathological disease in a Syrian hamster model of COVID-19

por Esparza, Thomas J., Chen, Yaozong, Martin, Negin P., Bielefeldt-Ohmann, Helle, Bowen, Richard A., Tolbert, William D., Pazgier, Marzena, Brody, David L.
Publicado 2021

Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19

por Esparza, Thomas J., Chen, Yaozong, Martin, Negin P., Bielefeldt-Ohmann, Helle, Bowen, Richard A., Tolbert, William D., Pazgier, Marzena, Brody, David L.
Publicado 2022

Antibody-Dependent Cellular Cytotoxicity-Competent Antibodies against HIV-1-Infected Cells in Plasma from HIV-Infected Subjects

por Dupuy, Franck P., Kant, Sanket, Barbé, Alexandre, Routy, Jean-Pierre, Bruneau, Julie, Lebouché, Bertrand, Tremblay, Cécile, Pazgier, Marzena, Finzi, Andrés, Bernard, Nicole F.
Publicado 2019

Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression

por Li, Xiang, Gohain, Neelakshi, Chen, Si, Li, Yinghua, Zhao, Xiaoyuan, Li, Bo, Tolbert, William D., He, Wangxiao, Pazgier, Marzena, Hu, Honggang, Lu, Wuyuan
Publicado 2021

HIV-1 Envelope Glycoprotein Cell Surface Localization Is Associated with Antibody-Induced Internalization

por Anand, Sai Priya, Prévost, Jérémie, Descôteaux-Dinelle, Jade, Richard, Jonathan, Nguyen, Dung N., Medjahed, Halima, Chen, Hung-Ching, Smith, Amos B., Pazgier, Marzena, Finzi, Andrés
Publicado 2021

Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design

por Li, Xiang, Tolbert, W. David, Hu, Hong-Gang, Gohain, Neelakshi, Zou, Yan, Niu, Fan, He, Wang-Xiao, Yuan, Weirong, Su, Jia-Can, Pazgier, Marzena, Lu, Wuyuan
Publicado 2018

Incorporating the Cluster A and V1V2 Targets into a Minimal Structural Unit of the HIV-1 Envelope to Elicit a Cross-Clade Response with Potent Fc-Effector Functions

por Sherburn, Rebekah, Tolbert, William D., Gottumukkala, Suneetha, Hederman, Andrew P., Beaudoin-Bussières, Guillaume, Stanfield-Oakley, Sherry, Tuyishime, Marina, Ferrari, Guido, Finzi, Andrés, Ackerman, Margaret E., Pazgier, Marzena
Publicado 2021