Machine Learning-driven Fragment-based Discovery of CIB1-directed Anti-Tumor Agents by FRASE-bot

por An, Yi, Glavatskikh, Marta, Lim, Jiwoong, Wang, Xiaowen, Norris-Drouin, Jacqueline, Hardy, P. Brian, Leisner, Tina M., Pearce, Kenneth H., Kireev, Dmitri
Publicado 2023

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

por Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
Publicado 2016

Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

por Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
Publicado 2017

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

por Gao, Yanzhe, Mutter-Rottmayer, Elizabeth, Greenwalt, Alicia M., Goldfarb, Dennis, Yan, Feng, Yang, Yang, Martinez-Chacin, Raquel C., Pearce, Kenneth H., Tateishi, Satoshi, Major, Michael B., Vaziri, Cyrus
Publicado 2016

Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins

por Lamb, Kelsey N., Dishman, Sarah N., Waybright, Jarod M., Engelberg, Isabelle A., Rectenwald, Justin M., Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Pearce, Kenneth H., James, Lindsey I., Frye, Stephen V.
Publicado 2021

Fused Tetrahydroquinolines Are Interfering with Your Assay

por Bashore, Frances M., Annor-Gyamfi, Joel, Du, Yuhong, Katis, Vittorio, Nwogbo, Felix, Flax, Raymond G., Frye, Stephen V., Pearce, Kenneth H., Fu, Haian, Willson, Timothy M., Drewry, David H., Axtman, Alison D.
Publicado 2023

Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins

por Rectenwald, Justin M., Guduru, Shiva Krishna Reddy, Dang, Zhao, Collins, Leonard B., Liao, Yi-En, Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Kaufmann, Kyle W., Hammond, Scott M., Kireev, Dmitri B., Frye, Stephen V., Pearce, Kenneth H.
Publicado 2020

Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer’s disease

por Du, Yuhong, Bradshaw, William J., Leisner, Tina M., Annor-Gyamfi, Joel K., Qian, Kun, Bashore, Frances M., Sikdar, Arunima, Nwogbo, Felix O., Ivanov, Andrey A., Frye, Stephen V., Gileadi, Opher, Brennan, Paul E., Levey, Allan I., Axtman, Alison D., Pearce, Kenneth H., Fu, Haian, Katis, Vittorio L.
Publicado 2023

Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease

por Du, Yuhong, Bradshaw, William J., Leisner, Tina M., Annor-Gyamfi, Joel K., Qian, Kun, Bashore, Frances M., Sikdar, Arunima, Nwogbo, Felix O., Ivanov, Andrey A., Frye, Stephen V., Gileadi, Opher, Brennan, Paul E., Levey, Allan I., Axtman, Alison D., Pearce, Kenneth H., Fu, Haian, Katis, Vittorio L.
Publicado 2023

Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors

por Puhl, Ana C., Mottin, Melina, Sacramento, Carolina Q., Tavella, Tatyana Almeida, Dias, Gabriel Gonçalves, Fintelman-Rodrigues, Natalia, Temerozo, Jairo R., Dias, Suelen S. G., Ramos, Paulo Ricardo Pimenta da Silva, Merten, Eric M., Pearce, Kenneth H., Costa, Fabio Trindade Maranhão, Premkumar, Lakshmanane, Souza, Thiago Moreno L., Andrade, Carolina Horta, Ekins, Sean
Publicado 2022

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

por Bashore, Frances M., Katis, Vittorio L., Du, Yuhong, Sikdar, Arunima, Wang, Dongxue, Bradshaw, William J., Rygiel, Karolina A., Leisner, Tina M., Chalk, Rod, Mishra, Swati, Williams, Andrew C., Gileadi, Opher, Brennan, Paul E., Wiley, Jesse C., Gockley, Jake, Cary, Gregory A., Carter, Gregory W., Young, Jessica E., Pearce, Kenneth H., Fu, Haian, Axtman, Alison D.
Publicado 2023

Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice

por Puhl, Ana C., Gomes, Giovanni F., Damasceno, Samara, Fritch, Ethan J., Levi, James A., Johnson, Nicole J., Scholle, Frank, Premkumar, Lakshmanane, Hurst, Brett L., LeeMontiel, Felipe, Veras, Flavio P., Batah, Sabrina S., Fabro, Alexandre T., Moorman, Nathaniel J., Yount, Boyd L., Dickmander, Rebekah, Baric, Ralph, Pearce, Kenneth H., Cunha, Fernando Q., Alves-Filho, José C., Cunha, Thiago M., Ekins, Sean
Publicado 2021

Vandetanib Blocks the Cytokine Storm in SARS-CoV-2-Infected Mice

por Puhl, Ana C., Gomes, Giovanni F., Damasceno, Samara, Fritch, Ethan J., Levi, James A., Johnson, Nicole J., Scholle, Frank, Premkumar, Lakshmanane, Hurst, Brett L., Lee-Montiel, Felipe, Veras, Flavio P., Batah, Sabrina S., Fabro, Alexandre T., Moorman, Nathaniel J., Yount, Boyd L., Dickmander, Rebekah J., Baric, Ralph S., Pearce, Kenneth H., Cunha, Fernando Q., Alves-Filho, José C., Cunha, Thiago M., Ekins, Sean
Publicado 2022

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms

por Puhl, Ana C., Fritch, Ethan James, Lane, Thomas R., Tse, Longping V., Yount, Boyd L., Sacramento, Carol Queiroz, Tavella, Tatyana Almeida, Costa, Fabio Trindade Maranhão, Weston, Stuart, Logue, James, Frieman, Matthew, Premkumar, Lakshmanane, Pearce, Kenneth H., Hurst, Brett L., Andrade, Carolina Horta, Levi, James A., Johnson, Nicole J., Kisthardt, Samantha C., Scholle, Frank, Souza, Thiago Moreno L., Moorman, Nathaniel John, Baric, Ralph S., Madrid, Peter, Ekins, Sean
Publicado 2020

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms

por Puhl, Ana C., Fritch, Ethan J., Lane, Thomas R., Tse, Longping V., Yount, Boyd L., Sacramento, Carolina Q., Fintelman-Rodrigues, Natalia, Tavella, Tatyana Almeida, Maranhão Costa, Fabio Trindade, Weston, Stuart, Logue, James, Frieman, Matthew, Premkumar, Lakshmanane, Pearce, Kenneth H., Hurst, Brett L., Andrade, Carolina Horta, Levi, James A., Johnson, Nicole J., Kisthardt, Samantha C., Scholle, Frank, Souza, Thiago Moreno L., Moorman, Nathaniel John, Baric, Ralph S., Madrid, Peter B., Ekins, Sean
Publicado 2021

Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology

por Potjewyd, Frances M., Annor‐Gyamfi, Joel K., Aubé, Jeffrey, Chu, Shaoyou, Conlon, Ivie L., Frankowski, Kevin J., Guduru, Shiva K. R., Hardy, Brian P., Hopkins, Megan D., Kinoshita, Chizuru, Kireev, Dmitri B., Mason, Emily R., Moerk, Charles T., Nwogbo, Felix, Pearce, Kenneth H., Richardson, Timothy I., Rogers, David A., Soni, Disha M., Stashko, Michael, Wang, Xiaodong, Wells, Carrow, Willson, Timothy M., Frye, Stephen V., Young, Jessica E., Axtman, Alison D.
Publicado 2022

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

por Potjewyd, Frances M., Annor‐Gyamfi, Joel K., Aubé, Jeffrey, Chu, Shaoyou, Conlon, Ivie L., Frankowski, Kevin J., Guduru, Shiva K. R., Hardy, Brian P., Hopkins, Megan D., Kinoshita, Chizuru, Kireev, Dmitri B., Mason, Emily R., Moerk, Charles T., Nwogbo, Felix, Pearce, Kenneth H., Richardson, Timothy I., Rogers, David A., Soni, Disha M., Stashko, Michael, Wang, Xiaodong, Wells, Carrow, Willson, Timothy M., Frye, Stephen V., Young, Jessica E., Axtman, Alison D.
Publicado 2022