Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

por Berenjeno, Inma M., Guillermet-Guibert, Julie, Pearce, Wayne, Gray, Alexander, Fleming, Stewart, Vanhaesebroeck, Bart
Publicado 2012

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

por Foukas, Lazaros C, Bilanges, Benoit, Bettedi, Lucia, Pearce, Wayne, Ali, Khaled, Sancho, Sara, Withers, Dominic J, Vanhaesebroeck, Bart
Publicado 2013

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice

por Alliouachene, Samira, Bilanges, Benoit, Chaussade, Claire, Pearce, Wayne, Foukas, Lazaros C., Scudamore, Cheryl L., Moniz, Larissa S., Vanhaesebroeck, Bart
Publicado 2016

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner

por Madsen, Ralitsa R., Knox, Rachel G., Pearce, Wayne, Lopez, Saioa, Mahler-Araujo, Betania, McGranahan, Nicholas, Vanhaesebroeck, Bart, Semple, Robert K.
Publicado 2019

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

por Soler, Adriana, Serra, Helena, Pearce, Wayne, Angulo, Ana, Guillermet-Guibert, Julie, Friedman, Lori S., Viñals, Francesc, Gerhardt, Holger, Casanovas, Oriol, Graupera, Mariona, Vanhaesebroeck, Bart
Publicado 2013

Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development

por Tibarewal, Priyanka, Rathbone, Victoria, Constantinou, Georgia, Pearce, Wayne, Adil, Mahreen, Varyova, Zofia, Folkes, Lisa, Hampson, Alix, Classen, Gala Anastasia Electra, Alves, Adriana, Carvalho, Sara, Scudamore, Cheryl L, Vanhaesebroeck, Bart
Publicado 2022

Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer

por Ali, Khaled, Soond, Dalya R., Pineiro, Roberto, Hagemann, Thorsten, Pearce, Wayne, Lim, Ee Lyn, Bouabe, Hicham, Scudamore, Cheryl L., Hancox, Timothy, Maecker, Heather, Friedman, Lori, Turner, Martin, Okkenhaug, Klaus, Vanhaesebroeck, Bart
Publicado 2014

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

por Alliouachene, Samira, Bilanges, Benoit, Chicanne, Gaëtan, Anderson, Karen E., Pearce, Wayne, Ali, Khaled, Valet, Colin, Posor, York, Low, Pei Ching, Chaussade, Claire, Scudamore, Cheryl L., Salamon, Rachel S., Backer, Jonathan M., Stephens, Len, Hawkins, Phill T., Payrastre, Bernard, Vanhaesebroeck, Bart
Publicado 2015

Control of Axonal Growth and Regeneration of Sensory Neurons by the p110δ PI 3-Kinase

por Eickholt, Britta J., Ahmed, Aminul I., Davies, Meirion, Papakonstanti, Evangelia A., Pearce, Wayne, Starkey, Michelle L., Bilancio, Antonio, Need, Anna C., Smith, Andrew J. H., Hall, Susan M., Hamers, Frank P., Giese, Karl P., Bradbury, Elizabeth J., Vanhaesebroeck, Bart
Publicado 2007

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells

por Guillermet-Guibert, Julie, Smith, Lee B., Halet, Guillaume, Whitehead, Maria A., Pearce, Wayne, Rebourcet, Diane, León, Kelly, Crépieux, Pascale, Nock, Gemma, Strömstedt, Maria, Enerback, Malin, Chelala, Claude, Graupera, Mariona, Carroll, John, Cosulich, Sabina, Saunders, Philippa T. K., Huhtaniemi, Ilpo, Vanhaesebroeck, Bart
Publicado 2015

Real-world, feasibility study to investigate the use of a multidisciplinary app (Pulsara) to improve prehospital communication and timelines for acute stroke/STEMI care

por Bladin, Chris F, Bagot, Kathleen L, Vu, Michelle, Kim, Joosup, Bernard, Stephen, Smith, Karen, Hocking, Grant, Coupland, Tessa, Pearce, Debra, Badcock, Diane, Budge, Marc, Nadurata, Voltaire, Pearce, Wayne, Hall, Howard, Kelly, Ben, Spencer, Angie, Chapman, Pauline, Oqueli, Ernesto, Sahathevan, Ramesh, Kraemer, Thomas, Hair, Casey, Stub, Dion, Cadilhac, Dominique A
Publicado 2022

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

por Berenjeno, Inma M., Piñeiro, Roberto, Castillo, Sandra D., Pearce, Wayne, McGranahan, Nicholas, Dewhurst, Sally M., Meniel, Valerie, Birkbak, Nicolai J., Lau, Evelyn, Sansregret, Laurent, Morelli, Daniele, Kanu, Nnennaya, Srinivas, Shankar, Graupera, Mariona, Parker, Victoria E. R., Montgomery, Karen G., Moniz, Larissa S., Scudamore, Cheryl L., Phillips, Wayne A., Semple, Robert K., Clarke, Alan, Swanton, Charles, Vanhaesebroeck, Bart
Publicado 2017

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

por Bilanges, Benoit, Alliouachene, Samira, Pearce, Wayne, Morelli, Daniele, Szabadkai, Gyorgy, Chung, Yuen-Li, Chicanne, Gaëtan, Valet, Colin, Hill, Julia M., Voshol, Peter J., Collinson, Lucy, Peddie, Christopher, Ali, Khaled, Ghazaly, Essam, Rajeeve, Vinothini, Trichas, Georgios, Srinivas, Shankar, Chaussade, Claire, Salamon, Rachel S., Backer, Jonathan M., Scudamore, Cheryl L., Whitehead, Maria A., Keaney, Erin P., Murphy, Leon O., Semple, Robert K., Payrastre, Bernard, Tooze, Sharon A., Vanhaesebroeck, Bart
Publicado 2017

Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

por Lechner, Matt, Schartinger, Volker H., Steele, Christopher D., Nei, Wen Long, Ooft, Marc Lucas, Schreiber, Liesa-Marie, Pipinikas, Christodoulos P., Chung, Grace Tin-Yun, Chan, Yuk Yu, Wu, Feng, To, Ka-Fai, Tsang, Chi Man, Pearce, Wayne, Morelli, Daniele, Philpott, Martin, Masterson, Liam, Nibhani, Reshma, Wells, Graham, Bell, Christopher G., Koller, Julia, Delecluse, Susanne, Yip, Yim Ling, Liu, Jacklyn, Forde, Cillian T., Forster, Martin D., Jay, Amrita, Dudás, József, Krapp, Annika, Wan, Simon, Uprimny, Christian, Sprung, Susanne, Haybaeck, Johannes, Fenton, Tim R., Chester, Kerry, Thirlwell, Christina, Royle, Gary, Marafioti, Teresa, Gupta, Rajeev, Indrasari, Sagung Rai, Herdini, Camelia, Slim, Mohd Afiq Mohd, Indrawati, I., Sutton, Liam, Fles, Renske, Tan, Bing, Yeong, Joe, Jain, Amit, Han, Shuting, Wang, Haitao, Loke, Kelvin S. H., He, Wan, Xu, Ruilian, Jin, Hongtao, Cheng, Zhiqiang, Howard, David, Hwang, Peter H., Le, Quynh-Thu, Tay, Joshua K., West, Robert B., Tsao, Sai Wah, Meyer, Tim, Riechelmann, Herbert, Oppermann, Udo, Delecluse, Henri-Jacques, Willems, Stefan M., Chua, Melvin L. K., Busson, Pierre, Lo, Kwok Wai, Wollmann, Guido, Pillay, Nischalan, Vanhaesebroeck, Bart, Lund, Valerie J.
Publicado 2021