Computational Approaches to Identify Genetic Interactions for Cancer Therapeutics

por Benstead-Hume, Graeme, Wooller, Sarah K., Pearl, Frances M.G.
Publicado 2017

Identification and analysis of mutational hotspots in oncogenes and tumour suppressors

por Baeissa, Hanadi, Benstead-Hume, Graeme, Richardson, Christopher J., Pearl, Frances M.G
Publicado 2017

Defining Signatures of Arm-Wise Copy Number Change and Their Associated Drivers in Kidney Cancers

por Benstead-Hume, Graeme, Wooller, Sarah K., Downs, Jessica A, Pearl, Frances M. G.
Publicado 2019

CATHEDRAL: A Fast and Effective Algorithm to Predict Folds and Domain Boundaries from Multidomain Protein Structures

por Redfern, Oliver C, Harrison, Andrew, Dallman, Tim, Pearl, Frances M. G, Orengo, Christine A
Publicado 2007

Bioinformatics in translational drug discovery

por Wooller, Sarah K., Benstead-Hume, Graeme, Chen, Xiangrong, Ali, Yusuf, Pearl, Frances M.G.
Publicado 2017

MoKCa database—mutations of kinases in cancer

por Richardson, Christopher J., Gao, Qiong, Mitsopoulous, Costas, Zvelebil, Marketa, Pearl, Laurence H., Pearl, Frances M. G.
Publicado 2009

Predicting synthetic lethal interactions using conserved patterns in protein interaction networks

por Benstead-Hume, Graeme, Chen, Xiangrong, Hopkins, Suzanna R., Lane, Karen A., Downs, Jessica A., Pearl, Frances M. G.
Publicado 2019

VIDA: a virus database system for the organization of animal virus genome open reading frames

por Albà, M. Mar, Lee, David, Pearl, Frances M. G., Shepherd, Adrian J., Martin, Nigel, Orengo, Christine A., Kellam, Paul
Publicado 2001

Biological network topology features predict gene dependencies in cancer cell-lines

por Benstead-Hume, Graeme, Wooller, Sarah K, Renaut, Joanna, Dias, Samantha, Woodbine, Lisa, Carr, Antony M, Pearl, Frances M G
Publicado 2022

Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness

por Schiavoni, Federica, Zuazua-Villar, Pedro, Roumeliotis, Theodoros I., Benstead-Hume, Graeme, Pardo, Mercedes, Pearl, Frances M. G., Choudhary, Jyoti S., Downs, Jessica A.
Publicado 2022

Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability

por Meisenberg, Cornelia, Pinder, Sarah I., Hopkins, Suzanna R., Wooller, Sarah K., Benstead-Hume, Graeme, Pearl, Frances M.G., Jeggo, Penny A., Downs, Jessica A.
Publicado 2019

Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping

por Lane, Rosemary, Simon, Thomas, Vintu, Marian, Solkin, Benjamin, Koch, Barbara, Stewart, Nicolas, Benstead-Hume, Graeme, Pearl, Frances M. G., Critchley, Giles, Stebbing, Justin, Giamas, Georgios
Publicado 2019

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

por Ocasio, Cory A., Rajasekaran, Mohan B., Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M.G., Ward, Simon E., Savic, Velibor, Pearl, Laurence H., Hochegger, Helfrid, Oliver, Antony W.
Publicado 2016

Mouse and Human Genetic Analyses Associate Kalirin with Ventral Striatal Activation during Impulsivity and with Alcohol Misuse

por Peña-Oliver, Yolanda, Carvalho, Fabiana M., Sanchez-Roige, Sandra, Quinlan, Erin B., Jia, Tianye, Walker-Tilley, Tom, Rulten, Stuart L., Pearl, Frances M. G., Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Büchel, Christian, Conrod, Patricia J., Flor, Herta, Gallinat, Jürgen, Garavan, Hugh, Heinz, Andreas, Gowland, Penny, Paillere Martinot, Marie-Laure, Paus, Tomáš, Rietschel, Marcella, Robbins, Trevor W., Smolka, Michael N., Schumann, Gunter, Stephens, David N.
Publicado 2016