Computational Approaches to Identify Genetic Interactions for Cancer Therapeutics

por Benstead-Hume, Graeme, Wooller, Sarah K., Pearl, Frances M.G.
Publicado 2017

Identification and analysis of mutational hotspots in oncogenes and tumour suppressors

por Baeissa, Hanadi, Benstead-Hume, Graeme, Richardson, Christopher J., Pearl, Frances M.G
Publicado 2017

Bioinformatics in translational drug discovery

por Wooller, Sarah K., Benstead-Hume, Graeme, Chen, Xiangrong, Ali, Yusuf, Pearl, Frances M.G.
Publicado 2017

Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability

por Meisenberg, Cornelia, Pinder, Sarah I., Hopkins, Suzanna R., Wooller, Sarah K., Benstead-Hume, Graeme, Pearl, Frances M.G., Jeggo, Penny A., Downs, Jessica A.
Publicado 2019

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

por Ocasio, Cory A., Rajasekaran, Mohan B., Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M.G., Ward, Simon E., Savic, Velibor, Pearl, Laurence H., Hochegger, Helfrid, Oliver, Antony W.
Publicado 2016

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

por Chen, Xiangrong, Ali, Yusuf I, Fisher, Charlotte EL, Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B, Williams, Gareth, Walker, Sarah, Booth, Jessica R, Hudson, Jessica JR, Roe, S Mark, Pearl, Laurence H, Ward, Simon E, Pearl, Frances MG, Oliver, Antony W
Publicado 2021