Review: The HSP90 molecular chaperone—an enigmatic ATPase

por Pearl, Laurence H.
Publicado 2016

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

por Rappas, Mathieu, Oliver, Antony W., Pearl, Laurence H.
Publicado 2011

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

por Rappas, Mathieu, Oliver, Antony W., Pearl, Laurence H.
Publicado 2013

Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1

por Day, Matthew, Oliver, Antony W., Pearl, Laurence H.
Publicado 2021

Structure of the human RAD17–RFC clamp loader and 9–1–1 checkpoint clamp bound to a dsDNA–ssDNA junction

por Day, Matthew, Oliver, Antony W, Pearl, Laurence H
Publicado 2022

A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s

por Vaughan, Cara K, Piper, Peter W, Pearl, Laurence H, Prodromou, Chrisostomos
Publicado 2009

Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors

por Zhang, Minghao, Kadota, Yasuhiro, Prodromou, Chrisostomos, Shirasu, Ken, Pearl, Laurence H.
Publicado 2010

HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients

por Li, Zhaobo, Zhou, Lihong, Prodromou, Chrisostomos, Savic, Velibor, Pearl, Laurence H.
Publicado 2017

The BAH domain of Rsc2 is a histone H3 binding domain

por Chambers, Anna L., Pearl, Laurence H., Oliver, Antony W., Downs, Jessica A.
Publicado 2013

Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK

por Ali, Ammar A. E., Jukes, Rachel M., Pearl, Laurence H., Oliver, Antony W.
Publicado 2009

Visualization of a DNA-PK/PARP1 complex

por Spagnolo, Laura, Barbeau, Jody, Curtin, Nicola J., Morris, Edward P., Pearl, Laurence H.
Publicado 2012

Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes

por Morgan, Rhodri M. L., Pal, Mohinder, Roe, S. Mark, Pearl, Laurence H., Prodromou, Chrisostomos
Publicado 2015

The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90

por Blundell, Katie L. I. M., Pal, Mohinder, Roe, S. Mark, Pearl, Laurence H., Prodromou, Chrisostomos
Publicado 2017

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

por Day, Matthew, Rappas, Mathieu, Ptasinska, Katie, Boos, Dominik, Oliver, Antony W, Pearl, Laurence H
Publicado 2018

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein

por Day, Matthew, Parry-Morris, Sarah, Houghton-Gisby, Jack, Oliver, Antony W., Pearl, Laurence H.
Publicado 2021

MoKCa database—mutations of kinases in cancer

por Richardson, Christopher J., Gao, Qiong, Mitsopoulous, Costas, Zvelebil, Marketa, Pearl, Laurence H., Pearl, Frances M. G.
Publicado 2009

Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism

por Schulze, Andrea, Beliu, Gerti, Helmerich, Dominic A., Schubert, Jonathan, Pearl, Laurence H., Prodromou, Chrisostomos, Neuweiler, Hannes
Publicado 2016

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

por Bigot, Nicolas, Day, Matthew, Baldock, Robert A, Watts, Felicity Z, Oliver, Antony W, Pearl, Laurence H
Publicado 2019

Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes

por Zhang, Minghao, Botër, Marta, Li, Kuoyu, Kadota, Yasuhiro, Panaretou, Barry, Prodromou, Chrisostomos, Shirasu, Ken, Pearl, Laurence H
Publicado 2008

A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli

por Ioannou, Yiannis, Giles, Ian, Lambrianides, Anastasia, Richardson, Chris, Pearl, Laurence H, Latchman, David S, Isenberg, David A, Rahman, Anisur
Publicado 2006