Targeting increased levels of APP in Down syndrome: Posiphen‐mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model

por Chen, Xu‐Qiao, Salehi, Ahmad, Pearn, Matthew L., Overk, Cassia, Nguyen, Phuong D., Kleschevnikov, Alexander M., Maccecchini, Maria, Mobley, William C.
Publicado 2020

A γ-Secretase Inhibitor, but Not a γ-Secretase Modulator, Induced Defects in BDNF Axonal Trafficking and Signaling: Evidence for a Role for APP

por Weissmiller, April M., Natera-Naranjo, Orlangie, Reyna, Sol M., Pearn, Matthew L., Zhao, Xiaobei, Nguyen, Phuong, Cheng, Soan, Goldstein, Lawrence S. B., Tanzi, Rudolph E., Wagner, Steven L., Mobley, William C., Wu, Chengbiao
Publicado 2015

Loss of Caveolin-1 Accelerates Neurodegeneration and Aging

por Head, Brian P., Peart, Jason N., Panneerselvam, Mathivadhani, Yokoyama, Takaakira, Pearn, Matthew L., Niesman, Ingrid R., Bonds, Jacqueline A., Schilling, Jan M., Miyanohara, Atsushi, Headrick, John, Ali, Sameh S., Roth, David M., Patel, Piyush M., Patel, Hemal H.
Publicado 2010

An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome

por Belichenko, Pavel V., Madani, Rime, Rey-Bellet, Lorianne, Pihlgren, Maria, Becker, Ann, Plassard, Adeline, Vuillermot, Stephanie, Giriens, Valérie, Nosheny, Rachel L., Kleschevnikov, Alexander M., Valletta, Janice S., Bengtsson, Sara K. S., Linke, Gordon R., Maloney, Michael T., Hickman, David T., Reis, Pedro, Granet, Anne, Mlaki, Dorin, Lopez-Deber, Maria Pilar, Do, Long, Singhal, Nishant, Masliah, Eliezer, Pearn, Matthew L., Pfeifer, Andrea, Muhs, Andreas, Mobley, William C.
Publicado 2016