Structural and mechanistic analysis of trans-3-chloroacrylic acid dehalogenase activity

por Pegan, Scott D., Serrano, Hector, Whitman, Christian P., Mesecar, Andrew D.
Publicado 2008

ISG15: It's Complicated

por Dzimianski, John V., Scholte, Florine E.M., Bergeron, Éric, Pegan, Scott D.
Publicado 2019

Structure of interferon‐stimulated gene product 15 (ISG15) from the bat species Myotis davidii and the impact of interdomain ISG15 interactions on viral protein engagement

por Langley, Caroline, Goodwin, Octavia, Dzimianski, John V., Daczkowski, Courtney M., Pegan, Scott D.
Publicado 2019

Structural and Functional Characterization of Methicillin-Resistant Staphylococcus aureus’s Class IIb Fructose 1,6-Bisphosphate Aldolase

por Capodagli, Glenn C., Lee, Stephen A., Boehm, Kyle J., Brady, Kristin M., Pegan, Scott D.
Publicado 2014

Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist

por Udompholkul, Parima, Garza-Granados, Ana, Alboreggia, Giulia, Baggio, Carlo, McGuire, Jack, Pegan, Scott D., Pellecchia, Maurizio
Publicado 2023

Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species

por Daczkowski, Courtney M., Dzimianski, John V., Clasman, Jozlyn R., Goodwin, Octavia, Mesecar, Andrew D., Pegan, Scott D.
Publicado 2017

Development and validation of a yeast high-throughput screen for inhibitors of Aβ(42) oligomerization

por Park, Sei-Kyoung, Pegan, Scott D., Mesecar, Andrew D., Jungbauer, Lisa M., LaDu, Mary Jo, Liebman, Susan W.
Publicado 2011

Assessment of Inhibitors of Pathogenic Crimean-Congo Hemorrhagic Fever Virus Strains Using Virus-Like Particles

por Zivcec, Marko, Metcalfe, Maureen G., Albariño, César G., Guerrero, Lisa W., Pegan, Scott D., Spiropoulou, Christina F., Bergeron, Éric
Publicado 2015

Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity

por Dzimianski, John V., Beldon, Brianna S., Daczkowski, Courtney M., Goodwin, Octavia Y., Scholte, Florine E. M., Bergeron, Éric, Pegan, Scott D.
Publicado 2019

Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases

por Dzimianski, John V., Scholte, Florine E. M., Williams, Isabelle L., Langley, Caroline, Freitas, Brendan T., Spengler, Jessica R., Bergeron, Éric, Pegan, Scott D.
Publicado 2019

Identifying Drug Candidates for COVID-19 with Large-Scale Drug Screening

por Wu, Yifei, Pegan, Scott D., Crich, David, Lou, Lei, Mullininx, Lauren Nicole, Starling, Edward B., Booth, Carson, Chishom, Andrew Edward, Chang, Kuan Y., Xie, Zhong-Ru
Publicado 2023

Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase

por Zhai, Xiang, Go, Maybelle K., O’Donoghue, AnnMarie C., Amyes, Tina L., Pegan, Scott D., Wang, Yan, Loria, J. Patrick, Mesecar, Andrew D., Richard, John P.
Publicado 2014

Polyphenols as alternative treatments of COVID-19

por Wu, Yifei, Pegan, Scott D., Crich, David, Desrochers, Ellison, Starling, Edward B., Hansen, Madelyn C., Booth, Carson, Nicole Mullininx, Lauren, Lou, Lei, Chang, Kuan Y., Xie, Zhong-Ru
Publicado 2021

Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)

por Wu, Yifei, Crich, David, Pegan, Scott D., Lou, Lei, Hansen, Madelyn C., Booth, Carson, Desrochers, Ellison, Mullininx, Lauren Nicole, Starling, Edward B., Chang, Kuan Y., Xie, Zhong-Ru
Publicado 2021

The structural and biochemical impacts of monomerizing human acetylcholinesterase

por Bester, Stephanie M., Adipietro, Kaylin A., Funk, Vanessa L., Myslinski, James M., Keul, Nicholas D., Cheung, Jonah, Wilder, Paul T., Wood, Zachary A., Weber, David J., Height, Jude J., Pegan, Scott D.
Publicado 2019

Single-dose replicon particle vaccine provides complete protection against Crimean-Congo hemorrhagic fever virus in mice

por Scholte, Florine E. M., Spengler, Jessica R., Welch, Stephen R., Harmon, Jessica R., Coleman-McCray, JoAnn D., Freitas, Brendan T., Kainulainen, Markus H., Pegan, Scott D., Nichol, Stuart T., Bergeron, Éric, Spiropoulou, Christina F.
Publicado 2019

Vaccination with the Crimean-Congo hemorrhagic fever virus viral replicon vaccine induces NP-based T-cell activation and antibodies possessing Fc-mediated effector functions

por Scholte, F. E. M., Karaaslan, E., O’Neal, T. J., Sorvillo, T. E., Genzer, S. C., Welch, S. R., Coleman-McCray, J. D., Spengler, J. R., Kainulainen, M. H., Montgomery, J. M., Pegan, S. D., Bergeron, E., Spiropoulou, C. F.
Publicado 2023

Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection

por Scholte, Florine E. M., Hua, Brian L., Spengler, Jessica R., Dzimianski, John V., Coleman-McCray, JoAnn D., Welch, Stephen R., McMullan, Laura K., Nichol, Stuart T., Pegan, Scott D., Spiropoulou, Christina F., Bergeron, Éric
Publicado 2019

The Structure and Immune Regulatory Implications of the Ubiquitin-Like Tandem Domain Within an Avian 2’-5’ Oligoadenylate Synthetase-Like Protein

por Shepard, Justin D., Freitas, Brendan T., Rodriguez, Sergio E., Scholte, Florine E. M., Baker, Kailee, Hutchison, Madelyn R., Longo, Jaron E., Miller, Holden C., O’Boyle, Brady M., Tandon, Aarushi, Zhao, Peng, Grimsey, Neil J., Wells, Lance, Bergeron, Éric, Pegan, Scott D.
Publicado 2022

Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus

por Durie, Ian A., Tehrani, Zahra R., Karaaslan, Elif, Sorvillo, Teresa E., McGuire, Jack, Golden, Joseph W., Welch, Stephen R., Kainulainen, Markus H., Harmon, Jessica R., Mousa, Jarrod J., Gonzalez, David, Enos, Suzanne, Koksal, Iftihar, Yilmaz, Gurdal, Karakoc, Hanife Nur, Hamidi, Sanaz, Albay, Cansu, Spengler, Jessica R., Spiropoulou, Christina F., Garrison, Aura R., Sajadi, Mohammad M., Bergeron, Éric, Pegan, Scott D.
Publicado 2022