Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species

por Glover, Zephania Kwong, Wecksler, Aaron, Aryal, Baikuntha, Mehta, Shrenik, Pegues, Melissa, Chan, Wayman, Lehtimaki, Mari, Luo, Allen, Sreedhara, Alavattam, Rao, V. Ashutosh
Publicado 2022

Effect of Fatty Acid Composition in Polysorbate 80 on the Stability of Therapeutic Protein Formulations

por Pegues, Melissa A., Szczepanek, Karol, Sheikh, Faruk, Thacker, Seth G., Aryal, Baikuntha, Ghorab, Mohamed K, Wolfgang, Steven, Donnelly, Raymond P., Verthelyi, Daniela, Rao, V. Ashutosh
Publicado 2021

A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans

por Jones, Nicholas R, Pegues, Melissa A, McCrory, Mark A, Singleton, Walter, Bethune, Claudette, Baker, Brenda F, Norris, Daniel A, Crooke, Rosanne M, Graham, Mark J, Szalai, Alexander J
Publicado 2012

An etanercept O-glycovariant with enhanced potency

por Biel, Thomas G., Faison, Talia, Matthews, Alicia M., Zou, Guozhang, Ortega-Rodriguez, Uriel, Pegues, Melissa A., Azer, Nicole, Gomez, Fabiola, Johnson, Sarah, Rogstad, Sarah, Chen, Kang, Xie, Hang, Agarabi, Cyrus, Rao, V. Ashutosh, Ju, Tongzhong
Publicado 2022