Grabbing the Bull by Both Horns: Bovine Ultralong CDR-H3 Paratopes Enable Engineering of ‘Almost Natural’ Common Light Chain Bispecific Antibodies Suitable For Effector Cell Redire...

por Klewinghaus, Daniel, Pekar, Lukas, Arras, Paul, Krah, Simon, Valldorf, Bernhard, Kolmar, Harald, Zielonka, Stefan
Publicado 2022

Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

por Pekar, Lukas, Busch, Michael, Valldorf, Bernhard, Hinz, Steffen C., Toleikis, Lars, Krah, Simon, Zielonka, Stefan
Publicado 2020

A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization

por Arras, Paul, Yoo, Han Byul, Pekar, Lukas, Schröter, Christian, Clarke, Thomas, Krah, Simon, Klewinghaus, Daniel, Siegmund, Vanessa, Evers, Andreas, Zielonka, Stefan
Publicado 2023

Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

por Yanakieva, Desislava, Pekar, Lukas, Evers, Andreas, Fleischer, Markus, Keller, Stephan, Mueller-Pompalla, Dirk, Toleikis, Lars, Kolmar, Harald, Zielonka, Stefan, Krah, Simon
Publicado 2022

Cattle-derived knob paratopes grafted onto peripheral loops of the IgG1 Fc region enable the generation of a novel symmetric bispecific antibody format

por Yanakieva, Desislava, Vollmer, Lena, Evers, Andreas, Siegmund, Vanessa, Arras, Paul, Pekar, Lukas, Doerner, Achim, Valldorf, Bernhard, Kolmar, Harald, Zielonka, Stefan, Krah, Simon
Publicado 2023

Milking the Cow: Cattle-Derived Chimeric Ultralong CDR-H3 Antibodies and Their Engineered CDR-H3-Only Knobbody Counterparts Targeting Epidermal Growth Factor Receptor Elicit Potent...

por Pekar, Lukas, Klewinghaus, Daniel, Arras, Paul, Carrara, Stefania C., Harwardt, Julia, Krah, Simon, Yanakieva, Desislava, Toleikis, Lars, Smider, Vaughn V., Kolmar, Harald, Zielonka, Stefan
Publicado 2021

NKp46‐specific single domain antibodies enable facile engineering of various potent NK cell engager formats

por Lipinski, Britta, Arras, Paul, Pekar, Lukas, Klewinghaus, Daniel, Boje, Ammelie Svea, Krah, Simon, Zimmermann, Jasmin, Klausz, Katja, Peipp, Matthias, Siegmund, Vanessa, Evers, Andreas, Zielonka, Stefan
Publicado 2023

AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a pr...

por Arras, Paul, Yoo, Han Byul, Pekar, Lukas, Clarke, Thomas, Friedrich, Lukas, Schröter, Christian, Schanz, Jennifer, Tonillo, Jason, Siegmund, Vanessa, Doerner, Achim, Krah, Simon, Guarnera, Enrico, Zielonka, Stefan, Evers, Andreas
Publicado 2023

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition

por Lipinski, Britta, Unmuth, Laura, Arras, Paul, Becker, Stefan, Bauer, Christina, Toleikis, Lars, Krah, Simon, Doerner, Achim, Yanakieva, Desislava, Boje, Ammelie Svea, Klausz, Katja, Peipp, Matthias, Siegmund, Vanessa, Evers, Andreas, Kolmar, Harald, Pekar, Lukas, Zielonka, Stefan
Publicado 2023