KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis

por Tanner, Mark R., Pennington, Michael W., Chauhan, Satendra S., Laragione, Teresina, Gulko, Pércio S., Beeton, Christine
Publicado 2019

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

por Pennington, Michael W., Chang, Shih Chieh, Chauhan, Satendra, Huq, Redwan, Tajhya, Rajeev B., Chhabra, Sandeep, Norton, Raymond S., Beeton, Christine
Publicado 2015

A Conjugate between Lqh-8/6, a Natural Peptide Analogue of Chlorotoxin, and Doxorubicin Efficiently Induces Glioma Cell Death

por Dardevet, Lucie, Najlaoui, Feten, Aroui, Sonia, Collot, Mayeul, Tisseyre, Céline, Pennington, Michael W., Mallet, Jean-Maurice, De Waard, Michel
Publicado 2022

Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver

por Wang, Yuqing, Hurley, Ayrea, De Giorgi, Marco, Tanner, Mark R., Hu, Rong-Chi, Pennington, Michael W., Lagor, William R., Beeton, Christine
Publicado 2023

Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes

por Koshy, Shyny, Wu, Danli, Hu, Xueyou, Tajhya, Rajeev B., Huq, Redwan, Khan, Fatima S., Pennington, Michael W., Wulff, Heike, Yotnda, Patricia, Beeton, Christine
Publicado 2013

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

por Bergmann, Ralf, Kubeil, Manja, Zarschler, Kristof, Chhabra, Sandeep, Tajhya, Rajeev B., Beeton, Christine, Pennington, Michael W., Bachmann, Michael, Norton, Raymond S., Stephan, Holger
Publicado 2017

A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

por Wang, Yuqing, Zhu, Duolong, Ortiz-Velez, Laura C., Perry, Jacob L., Pennington, Michael W., Hyser, Joseph M., Britton, Robert A., Beeton, Christine
Publicado 2023

Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis

por Markakis, Ioannis, Charitakis, Ioannis, Beeton, Christine, Galani, Melpomeni, Repousi, Elpida, Aggeloglou, Stella, Sfikakis, Petros P., Pennington, Michael W., Chandy, K. George, Poulopoulou, Cornelia
Publicado 2021

A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation

por Rashid, M. Harunur, Heinzelmann, Germano, Huq, Redwan, Tajhya, Rajeev B., Chang, Shih Chieh, Chhabra, Sandeep, Pennington, Michael W., Beeton, Christine, Norton, Raymond S., Kuyucak, Serdar
Publicado 2013

Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia

por Nguyen, Hai M., di Lucente, Jacopo, Chen, Yi‐Je, Cui, Yanjun, Ibrahim, Rania H., Pennington, Michael W., Jin, Lee‐Way, Maezawa, Izumi, Wulff, Heike
Publicado 2020

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

por Rashid, M. Harunur, Huq, Redwan, Tanner, Mark R., Chhabra, Sandeep, Khoo, Keith K., Estrada, Rosendo, Dhawan, Vikas, Chauhan, Satendra, Pennington, Michael W., Beeton, Christine, Kuyucak, Serdar, Norton, Raymond S.
Publicado 2014

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

por Rangaraju, Srikant, Dammer, Eric B., Raza, Syed Ali, Rathakrishnan, Priyadharshini, Xiao, Hailian, Gao, Tianwen, Duong, Duc M., Pennington, Michael W., Lah, James J., Seyfried, Nicholas T., Levey, Allan I.
Publicado 2018

Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine

por Gulati, Sunita, Pennington, Michael W., Czerwinski, Andrzej, Carter, Darrick, Zheng, Bo, Nowak, Nancy A., DeOliveira, Rosane B., Shaughnessy, Jutamas, Reed, George W., Ram, Sanjay, Rice, Peter A.
Publicado 2019

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

por Rangaraju, Srikant, Raza, Syed Ali, Pennati, Andrea, Deng, Qiudong, Dammer, Eric B., Duong, Duc, Pennington, Michael W., Tansey, Malu G., Lah, James J., Betarbet, Ranjita, Seyfried, Nicholas T., Levey, Allan I.
Publicado 2017

Computational design of peptides to target Na(V)1.7 channel with high potency and selectivity for the treatment of pain

por Nguyen, Phuong T, Nguyen, Hai M, Wagner, Karen M, Stewart, Robert G, Singh, Vikrant, Thapa, Parashar, Chen, Yi-Je, Lillya, Mark W, Ton, Anh Tuan, Kondo, Richard, Ghetti, Andre, Pennington, Michael W, Hammock, Bruce, Griffith, Theanne N, Sack, Jon T, Wulff, Heike, Yarov-Yarovoy, Vladimir
Publicado 2022