Intracellular Injection of Brain Extracts from Alzheimer’s Disease Patients Triggers Unregulated Ca(2+) Release from Intracellular Stores That Hinders Cellular Bioenergetics

por Pensalfini, Anna, Umar, Abdul Rahim, Glabe, Charles, Parker, Ian, Ullah, Ghanim, Demuro, Angelo
Publicado 2022

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

por Kayed, Rakez, Canto, Isabel, Breydo, Leonid, Rasool, Suhail, Lukacsovich , Tamas, Wu, Jessica, Albay, Ricardo, Pensalfini, Anna, Yeung, Stephen, Head, Elizabeth, Marsh, J Lawrence, Glabe, Charles
Publicado 2010

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

por Rasool, Suhail, Albay, Ricardo, Martinez-Coria, Hilda, Breydo, Leonid, Wu, Jessica, Milton, Saskia, Misra, Sunit, Tran, Andy, Pensalfini, Anna, Laferla, Frank, Kayed, Rakez, Glabe, Charles G
Publicado 2012

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

por Lee, Ju-Hyun, Yang, Dun-Sheng, Goulbourne, Chris N., Im, Eunju, Stavrides, Philip, Pensalfini, Anna, Chan, Han, Bouchet-Marquis, Cedric, Bleiwas, Cynthia, Berg, Martin J., Huo, Chunfeng, Peddy, James, Pawlik, Monika, Levy, Efrat, Rao, Mala, Staufenbiel, Mathias, Nixon, Ralph A.
Publicado 2022

Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration

por Jiang, Ying, Alam, John J., Gomperts, Stephen N., Maruff, Paul, Lemstra, Afina W., Germann, Ursula A., Stavrides, Philip H., Darji, Sandipkumar, Malampati, Sandeep, Peddy, James, Bleiwas, Cynthia, Pawlik, Monika, Pensalfini, Anna, Yang, Dun-Sheng, Subbanna, Shivakumar, Basavarajappa, Balapal S., Smiley, John F., Gardner, Amanda, Blackburn, Kelly, Chu, Hui-May, Prins, Niels D., Teunissen, Charlotte E., Harrison, John E., Scheltens, Philip, Nixon, Ralph A.
Publicado 2022