New therapeutic perspectives – amyloid removal

por Pepys, Mark
Publicado 2015

The Pentraxins 1975–2018: Serendipity, Diagnostics and Drugs

por Pepys, Mark. B.
Publicado 2018

C-reactive protein predicts outcome in COVID-19: is it also a therapeutic target?

por Pepys, Mark B
Publicado 2021

Lack of Effect of a Single Injection of Human C-Reactive Protein on Murine Lupus or Nephrotoxic Nephritis

por Carlucci, Francesco, Terence Cook, H, Garg, Abhilok, Pepys, Mark B, Botto, Marina
Publicado 2010

Interleukin 6 Influences Germinal Center Development and Antibody Production via a Contribution of C3 Complement Component

por Kopf, Manfred, Herren, Suzanne, Wiles, Michael V., Pepys, Mark B., Kosco-Vilbois, Marie H.
Publicado 1998

Serum amyloid P component accumulates and persists in neurones following traumatic brain injury

por Yip, Ping K., Liu, Zhou-Hao, Hasan, Shumaila, Pepys, Mark B., Uff, Christopher E. G.
Publicado 2023

Genetic evidence for serum amyloid P component as a drug target for treatment of neurodegenerative disorders

por Schmidt, A Floriaan, Finan, Chris, Chopade, Sandesh, Ellmerich, Stephan, Rossor, Martin N, Hingorani, Aroon D, Pepys, Mark B
Publicado 2023

Interaction of serum amyloid P component with hexanoyl bis(d-proline) (CPHPC)

por Kolstoe, Simon E., Jenvey, Michelle C., Purvis, Alan, Light, Mark E., Thompson, Darren, Hughes, Peter, Pepys, Mark B., Wood, Stephen P.
Publicado 2014

Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction

por Milde, Ronny, Ritter, Julia, Tennent, Glenys A., Loesch, Andrzej, Martinez, Fernando O., Gordon, Siamon, Pepys, Mark B., Verschoor, Admar, Helming, Laura
Publicado 2015

Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo

por Al-Shawi, Raya, Tennent, Glenys A., Millar, David J., Richard-Londt, Angela, Brandner, Sebastian, Werring, David J., Simons, J. Paul, Pepys, Mark B.
Publicado 2016

Dementia in the older population is associated with neocortex content of serum amyloid P component

por Ellmerich, Stephan, Taylor, Graham W, Richardson, Connor D, Minett, Thais, Schmidt, Amand Floriaan, Brayne, Carol, Matthews, Fiona E, Ince, Paul G, Wharton, Stephen B, Pepys, Mark B
Publicado 2021

Equilibrium contrast CMR for the detection of amyloidosis in mice

por Campbell, Adrienne E, Price, Anthony N, Ellmerich, Stephan, Simons, Paul, Al-Shawi, Raya, Hawkins, Philip N, Ordidge, Roger J, Pepys, Mark B, Moon, James C, Lythgoe, Mark F
Publicado 2011

Randomized phase I trial HIV-CORE 003: Depletion of serum amyloid P component and immunogenicity of DNA vaccination against HIV-1

por Borthwick, Nicola J., Lane, Thirusha, Moyo, Nathifa, Crook, Alison, Shim, Jung Min, Baines, Ian, Wee, Edmund G., Hawkins, Philip N., Gillmore, Julian D., Hanke, Tomáš, Pepys, Mark B.
Publicado 2018

Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes

por Corazza, Alessandra, Verona, Guglielmo, Waudby, Christopher A., Mangione, P. Patrizia, Bingham, Ryan, Uings, Iain, Canetti, Diana, Nocerino, Paola, Taylor, Graham W., Pepys, Mark B., Christodoulou, John, Bellotti, Vittorio
Publicado 2019

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel

por Verona, Guglielmo, Mangione, P. Patrizia, Raimondi, Sara, Giorgetti, Sofia, Faravelli, Giulia, Porcari, Riccardo, Corazza, Alessandra, Gillmore, Julian D., Hawkins, Philip N., Pepys, Mark B., Taylor, Graham W., Bellotti, Vittorio
Publicado 2017

C-reactive protein is essential for innate resistance to pneumococcal infection

por Paul Simons, J, Loeffler, Jutta M, Al-Shawi, Raya, Ellmerich, Stephan, Hutchinson, Winston L, Tennent, Glenys A, Petrie, Aviva, Raynes, John G, de Souza, J Brian, Lawrence, Rachel A, Read, Kevin D, Pepys, Mark B
Publicado 2014

Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies

por Mangione, P. Patrizia, Mazza, Giuseppe, Gilbertson, Janet A., Rendell, Nigel B., Canetti, Diana, Giorgetti, Sofia, Frenguelli, Luca, Curti, Marco, Rezk, Tamer, Raimondi, Sara, Pepys, Mark B., Hawkins, Philip N., Gillmore, Julian D., Taylor, Graham W., Pinzani, Massimo, Bellotti, Vittorio
Publicado 2017

Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C‐reactive protein, for clinical use

por Pepys, Mark B., Gallimore, J. Ruth, Lloyd, Joanne, Li, Zhanhong, Graham, David, Taylor, Graham W., Ellmerich, Stephan, Mangione, Palma P., Tennent, Glenys A., Hutchinson, Winston L., Millar, David J., Bennett, Gary, More, John, Evans, David, Mistry, Yogesh, Poole, Stephen, Hawkins, Philip N.
Publicado 2012

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

por Marcoux, Julien, Mangione, P Patrizia, Porcari, Riccardo, Degiacomi, Matteo T, Verona, Guglielmo, Taylor, Graham W, Giorgetti, Sofia, Raimondi, Sara, Sanglier-Cianférani, Sarah, Benesch, Justin LP, Cecconi, Ciro, Naqvi, Mohsin M, Gillmore, Julian D, Hawkins, Philip N, Stoppini, Monica, Robinson, Carol V, Pepys, Mark B, Bellotti, Vittorio
Publicado 2015

Plasminogen activation triggers transthyretin amyloidogenesis in vitro

por Mangione, P. Patrizia, Verona, Guglielmo, Corazza, Alessandra, Marcoux, Julien, Canetti, Diana, Giorgetti, Sofia, Raimondi, Sara, Stoppini, Monica, Esposito, Marilena, Relini, Annalisa, Canale, Claudio, Valli, Maurizia, Marchese, Loredana, Faravelli, Giulia, Obici, Laura, Hawkins, Philip N., Taylor, Graham W., Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio
Publicado 2018