Revealing the activation mechanism of autoinhibited RalF by integrated simulation and experimental approaches

por Dudas, Balint, Perahia, David, Balog, Erika
Publicado 2021

Editorial: Integrative Structural Biology of Proteins and Macromolecular Assemblies: Bridging Experiments and Simulations

por Batista, Paulo Ricardo, Oliveira Neto, Mario, Perahia, David
Publicado 2022

Machine learning and structure-based modeling for the prediction of UDP-glucuronosyltransferase inhibition

por Dudas, Balint, Bagdad, Youcef, Picard, Milan, Perahia, David, Miteva, Maria A.
Publicado 2022

Mutation D816V Alters the Internal Structure and Dynamics of c-KIT Receptor Cytoplasmic Region: Implications for Dimerization and Activation Mechanisms

por Laine, Elodie, Chauvot de Beauchêne, Isaure, Perahia, David, Auclair, Christian, Tchertanov, Luba
Publicado 2011

Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling

por Dudas, Balint, Merzel, Franci, Jang, Hyunbum, Nussinov, Ruth, Perahia, David, Balog, Erika
Publicado 2020

Efficacy and safety of duloxetine 60 mg once daily in major depressive disorder: a review with expert commentary

por Ball, Susan G, Desaiah, Durisala, Zhang, Qi, Thase, Michael E, Perahia, David G S
Publicado 2013

Unveiling functional motions based on point mutations in biased signaling systems: A normal mode study on nerve growth factor bound to TrkA

por Resende-Lara, Pedro Túlio, Perahia, David, Scott, Ana Lígia, Braz, Antônio Sérgio Kimus
Publicado 2020

Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations

por Dudas, Balint, Toth, Daniel, Perahia, David, Nicot, Arnaud B., Balog, Erika, Miteva, Maria A.
Publicado 2021

Duloxetine in the treatment of major depressive disorder: an open-label study

por Hudson, James I, Perahia, David G, Gilaberte, Inmaculada, Wang, Fujun, Watkin, John G, Detke, Michael J
Publicado 2007

Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus

por Czigleczki, Janka, de Resende Lara, Pedro Tulio, Dudas, Balint, Jang, Hyunbum, Perahia, David, Nussinov, Ruth, Balog, Erika
Publicado 2023

Hepatic outcomes among adults taking duloxetine: a retrospective cohort study in a US health care claims database

por Lin, Nancy D., Norman, Heather, Regev, Arie, Perahia, David G., Li, Hu, Chang, Curtis Liming, Dore, David D.
Publicado 2015

The risk of bleeding with duloxetine treatment in patients who use nonsteroidal anti-inflammatory drugs (NSAIDs): analysis of placebo-controlled trials and post-marketing adverse e...

por Perahia, David G, Bangs, Mark E, Zhang, Qi, Cheng, Yingkai, Ahl, Jonna, Frakes, Elijah P, Adams, Michael J, Martinez, James M
Publicado 2013

The allosteric activation mechanism of a phospholipase A(2)-like toxin from Bothrops jararacussu venom: a dynamic description

por Gomes, Antoniel A. S., Cardoso, Fabio F., Souza, Maximilia F., Oliveira, Cristiano L. P., Perahia, David, Magro, Angelo J., Fontes, Marcos R. M.
Publicado 2020

New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies

por Fagnen, Charline, Bannwarth, Ludovic, Oubella, Iman, Forest, Eric, De Zorzi, Rita, de Araujo, Aline, Mhoumadi, Yasmina, Bendahhou, Saïd, Perahia, David, Vénien-Bryan, Catherine
Publicado 2020

Unexpected Gating Behaviour of an Engineered Potassium Channel Kir

por Fagnen, Charline, Bannwarth, Ludovic, Zuniga, Dania, Oubella, Iman, De Zorzi, Rita, Forest, Eric, Scala, Rosa, Guilbault, Samuel, Bendahhou, Saïd, Perahia, David, Vénien-Bryan, Catherine
Publicado 2021

Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain

por Fagnen, Charline, Bannwarth, Ludovic, Oubella, Iman, Zuniga, Dania, Haouz, Ahmed, Forest, Eric, Scala, Rosa, Bendahhou, Saïd, De Zorzi, Rita, Perahia, David, Vénien-Bryan, Catherine
Publicado 2021

Sampling of Protein Conformational Space Using Hybrid Simulations: A Critical Assessment of Recent Methods

por Kaynak, Burak T., Krieger, James M., Dudas, Balint, Dahmani, Zakaria L., Costa, Mauricio G. S., Balog, Erika, Scott, Ana Ligia, Doruker, Pemra, Perahia, David, Bahar, Ivet
Publicado 2022

Cryo–electron microscopy unveils unique structural features of the human Kir2.1 channel

por Fernandes, Carlos A. H., Zuniga, Dania, Fagnen, Charline, Kugler, Valérie, Scala, Rosa, Péhau-Arnaudet, Gérard, Wagner, Renaud, Perahia, David, Bendahhou, Saïd, Vénien-Bryan, Catherine
Publicado 2022

Dynamic Motion and Communication in the Streptococcal C1 Phage Lysin, PlyC

por Riley, Blake T., Broendum, Sebastian S., Reboul, Cyril F., Cowieson, Nathan P., Costa, Mauricio G. S., Kass, Itamar, Jackson, Colin, Perahia, David, Buckle, Ashley M., McGowan, Sheena
Publicado 2015

Structural Dynamics of DPP-4 and Its Influence on the Projection of Bioactive Ligands

por Pantaleão, Simone Queiroz, Philot, Eric Allison, de Resende-Lara, Pedro Túlio, Lima, Angélica Nakagawa, Perahia, David, Miteva, Maria Atanassova, Scott, Ana Ligia, Honorio, Kathia Maria
Publicado 2018