Novel Synthetic DNA Immunogens Targeting Latent Expressed Antigens of Epstein–Barr Virus Elicit Potent Cellular Responses and Inhibit Tumor Growth

por Wojtak, Krzysztof, Perales-Puchalt, Alfredo, Weiner, David B.
Publicado 2019

Simplifying checkpoint inhibitor delivery through in vivo generation of synthetic DNA-encoded monoclonal antibodies (DMAbs)

por Perales-Puchalt, Alfredo, Duperret, Elizabeth K., Muthumani, Kar, Weiner, David B.
Publicado 2019

A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation

por Bhojnagarwala, Pratik S., Perales-Puchalt, Alfredo, Cooch, Neil, Sardesai, Niranjan Y., Weiner, David B.
Publicado 2021

Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig

por Xu, Ziyang, Wise, Megan C., Choi, Hyeree, Perales-Puchalt, Alfredo, Patel, Ami, Tello-Ruiz, Edgar, Chu, Jacqueline D., Muthumani, Kar, Weiner, David B.
Publicado 2018

Immunotherapy of prostate cancer using novel synthetic DNA vaccines targeting multiple tumor antigens

por Bordoloi, Devivasha, Xiao, Peng, Choi, Hyeree, Ho, Michelle, Perales-Puchalt, Alfredo, Khoshnejad, Makan, Kim, J. Joseph, Humeau, Laurent, Srinivasan, Alagarsamy, Weiner, David B., Muthumani, Kar
Publicado 2021

Neutralization of hepatitis B virus by a novel DNA-encoded monoclonal antibody

por Zankharia, Urvi S., Kudchodkar, Sagar, Khoshnejad, Makan, Perales-Puchalt, Alfredo, Choi, Hyeree, Ho, Michelle, Zaidi, Faraz, Ugen, Kenneth E., Kim, Joseph J., Weiner, David B., Muthumani, Kar
Publicado 2020

Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo

por Khoshnejad, Makan, Perales-Puchalt, Alfredo, Dia, Yaya, Xiao, Peng, Patel, Ami, Xu, Ziyang, Zhu, Xizhou, Yun, Kun, Baboo, Ishana, Qureshi, Rehman, Humeau, Laurent, Muthumani, Kar, Weiner, David B.
Publicado 2020

IL-33 delays metastatic peritoneal cancer progression inducing an allergic microenvironment

por Perales-Puchalt, Alfredo, Svoronos, Nikolaos, Villarreal, Daniel O., Zankharia, Urvi, Reuschel, Emma, Wojtak, Krzysztof, Payne, Kyle K., Duperret, Elizabeth K., Muthumani, Kar, Conejo-Garcia, Jose R., Weiner, David B.
Publicado 2018

A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy

por Bordoloi, Devivasha, Bhojnagarwala, Pratik S., Perales-Puchalt, Alfredo, Kulkarni, Abhijeet J., Zhu, Xizhou, Liaw, Kevin, O’Connell, Ryan P., Park, Daniel H., Kulp, Daniel W., Zhang, Rugang, Weiner, David B.
Publicado 2022

P881: DURABILITY OF RESPONSES WITH BIWEEKLY DOSING OF TECLISTAMAB IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA ACHIEVING A CLINICAL RESPONSE IN THE MAJESTEC-1 STUDY

por Bhutani, Manisha, Garfall, Alfred, Uttervall, Katarina, Usmani, Saad Z, Karlin, Lionel, Benboubker, Lotfi, Nahi, Hareth, San Miguel, Jesús, Trancucci, Danielle, Qi, Keqin, Stephenson, Tara, Perales-Puchalt, Alfredo, Chastain, Katherine, Chari, Ajai
Publicado 2023

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

por Rutkowski, Melanie R., Allegrezza, Michael J., Svoronos, Nikolaos, Tesone, Amelia J., Stephen, Tom L., Perales-Puchalt, Alfredo, Nguyen, Jenny, Zhang, Paul J., Fiering, Steven N., Tchou, Julia, Conejo-Garcia, Jose R.
Publicado 2014

Engineered transfer RNAs for suppression of premature termination codons

por Lueck, John D., Yoon, Jae Seok, Perales-Puchalt, Alfredo, Mackey, Adam L., Infield, Daniel T., Behlke, Mark A., Pope, Marshall R., Weiner, David B., Skach, William R., McCray, Paul B., Ahern, Christopher A.
Publicado 2019

P911: EVALUATION OF PROPHYLACTIC TOCILIZUMAB (TOCI) FOR THE REDUCTION OF CYTOKINE RELEASE SYNDROME (CRS) TO INFORM THE MANAGEMENT OF PATIENTS (PTS) TREATED WITH TECLISTAMAB IN MAJE...

por van de Donk, Niels W.C.J., Garfall, Alfred, Benboubker, Lotfi, Uttervall, Katarina, Groen, Kaz, Rosiñol Dachs, Laura, Hodin, Caroline, Stephenson, Tara, Trancucci, Danielle, Perales-Puchalt, Alfredo, Kobos, Rachel, Banerjee, Arnob, Mateos, Maria-Victoria
Publicado 2023

DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas

por Zhu, Xizhou, Perales-Puchalt, Alfredo, Wojtak, Krzysztof, Xu, Ziyang, Yun, Kun, Bhojnagarwala, Pratik S., Bordoloi, Devivasha, Park, Daniel H., Liaw, Kevin, Bah, Mamadou A., Lieberman, Paul M., Gary, Ebony N., Patel, Ami, Weiner, David B.
Publicado 2021

Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape

por Park, Daniel H., Liaw, Kevin, Bhojnagarwala, Pratik, Zhu, Xizhou, Choi, Jihae, Ali, Ali R., Bordoloi, Devivasha, Gary, Ebony N., O’Connell, Ryan P., Kulkarni, Abhijeet, Guimet, Diana, Smith, Trevor, Perales-Puchalt, Alfredo, Patel, Ami, Weiner, David B.
Publicado 2023

Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers

por Bordoloi, Devivasha, Kulkarni, Abhijeet J., Adeniji, Opeyemi S., Pampena, M. Betina, Bhojnagarwala, Pratik S., Zhao, Shushu, Ionescu, Candice, Perales-Puchalt, Alfredo, Parzych, Elizabeth M., Zhu, Xizhou, Ali, Ali R., Cassel, Joel, Zhang, Rugang, Betts, Michael R., Abdel-Mohsen, Mohamed, Weiner, David B.
Publicado 2023

Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody

por Muthumani, Kar, Marnin, Liron, Kudchodkar, Sagar B., Perales-Puchalt, Alfredo, Choi, Hyeree, Agarwal, Sangya, Scott, Veronica L., Reuschel, Emma L., Zaidi, Faraz I., Duperret, Elizabeth K., Wise, Megan C., Kraynyak, Kimberly A., Ugen, Kenneth. E., Sardesai, Niranjan Y., Joseph Kim, J., Weiner, David B.
Publicado 2017

P1506: TECLISTAMAB REDUCES POLYCLONAL IMMUNOGLOBULIN LEVELS AND IMPAIRS VACCINATION RESPONSES IN HEAVILY PRETREATED MM PATIENTS

por Frerichs, Kristine, Verkleij, Christie, Mateos, Maria-Victoria, Zweegman, Sonja, Groen, Kaz, Kuipers, Ilse, Martin, Tom, Rodriguez, Cesar, Nooka, Ajay, Kruijswijk, Sandy, Skerget, Sheri, Doyle, Margaret, Banerjee, Arnob, Chastain, Katherine, Perales-Puchalt, Alfredo, Stephenson, Tara, Uhlar, Clarissa, Kobos, Rachel, Verona, Raluca, van de Donk, Niels W.C.J.
Publicado 2023

Nanoparticle Vaccines: In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity (Adv...

por Xu, Ziyang, Wise, Megan C., Chokkalingam, Neethu, Walker, Susanne, Tello‐Ruiz, Edgar, Elliott, Sarah T. C., Perales‐Puchalt, Alfredo, Xiao, Peng, Zhu, Xizhou, Pumroy, Ruth A., Fisher, Paul D., Schultheis, Katherine, Schade, Eric, Menis, Sergey, Guzman, Stacy, Andersen, Hanne, Broderick, Kate E., Humeau, Laurent M., Muthumani, Kar, Moiseenkova‐Bell, Vera, Schief, William R., Weiner, David B., Kulp, Daniel W.
Publicado 2020

In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity

por Xu, Ziyang, Wise, Megan C., Chokkalingam, Neethu, Walker, Susanne, Tello‐Ruiz, Edgar, Elliott, Sarah T. C., Perales‐Puchalt, Alfredo, Xiao, Peng, Zhu, Xizhou, Pumroy, Ruth A., Fisher, Paul D., Schultheis, Katherine, Schade, Eric, Menis, Sergey, Guzman, Stacy, Andersen, Hanne, Broderick, Kate E., Humeau, Laurent M., Muthumani, Kar, Moiseenkova‐Bell, Vera, Schief, William R., Weiner, David B., Kulp, Daniel W.
Publicado 2020