Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

por Preissler, Steffen, Rato, Claudia, Yan, Yahui, Perera, Luke A, Czako, Aron, Ron, David
Publicado 2020

Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD

por Perera, Luke A., Preissler, Steffen, Zaccai, Nathan R., Prévost, Sylvain, Devos, Juliette M., Haertlein, Michael, Ron, David
Publicado 2021

An oligomeric state‐dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP

por Perera, Luke A, Rato, Claudia, Yan, Yahui, Neidhardt, Lisa, McLaughlin, Stephen H, Read, Randy J, Preissler, Steffen, Ron, David
Publicado 2019

Infancy‐onset diabetes caused by de‐regulated AMPylation of the human endoplasmic reticulum chaperone BiP

por Perera, Luke A, Hattersley, Andrew T, Harding, Heather P, Wakeling, Matthew N, Flanagan, Sarah E, Mohsina, Ibrahim, Raza, Jamal, Gardham, Alice, Ron, David, De Franco, Elisa
Publicado 2023

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B

por Zyryanova, Alisa F., Kashiwagi, Kazuhiro, Rato, Claudia, Harding, Heather P., Crespillo-Casado, Ana, Perera, Luke A., Sakamoto, Ayako, Nishimoto, Madoka, Yonemochi, Mayumi, Shirouzu, Mikako, Ito, Takuhiro, Ron, David
Publicado 2021