First‐in‐human study of milvexian, an oral, direct, small molecule factor XIa inhibitor

por Perera, Vidya, Wang, Zhaoqing, Luettgen, Joseph, Li, Danshi, DeSouza, Mary, Cerra, Michael, Seiffert, Dietmar
Publicado 2021

Single-Dose Pharmacokinetics of Milvexian in Participants with Normal Renal Function and Participants with Moderate or Severe Renal Impairment

por Perera, Vidya, Abelian, Grigor, Li, Danshi, Wang, Zhaoqing, Zhang, Liping, Lubin, Susan, Bello, Akintunde, Murthy, Bindu
Publicado 2022

Single-Dose Pharmacokinetics of Milvexian in Participants with Mild or Moderate Hepatic Impairment Compared with Healthy Participants

por Perera, Vidya, Abelian, Grigor, Li, Danshi, Wang, Zhaoqing, Zhang, Liping, Lubin, Susan, Chen, Wei, Bello, Akintunde, Murthy, Bindu
Publicado 2022

Evaluation of safety, pharmacokinetics, and pharmacodynamics of apixaban in pediatric subjects at risk of venous or arterial thrombotic disorder

por Merali, Samira J., Byon, Wonkyung, Patel, Yogesh T., Elsrougy, Amira, Marchisin, David, Perera, Vidya, Chen, Weidong, He, Bing, Murthy, Bindu
Publicado 2023

Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21

por Sychterz, Caroline, Gardner, Iain, Chiang, Manting, Rachumallu, Ramakrishna, Neuhoff, Sibylle, Perera, Vidya, Merali, Samira, Schmidt, Brian J., Gaohua, Lu
Publicado 2022

Effects of Itraconazole and Diltiazem on the Pharmacokinetics and Pharmacodynamics of Milvexian, A Factor XIa Inhibitor

por Perera, Vidya, Wang, Zhaoqing, Lubin, Susan, Christopher, Lisa J., Chen, Wei, Xu, Sophia, Seiffert, Dietmar, DeSouza, Mary, Murthy, Bindu
Publicado 2022

Effects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor

por Perera, Vidya, Wang, Zhaoqing, Lubin, Susan, Christopher, Lisa J., Chen, Wei, Xu, Sophia, Seiffert, Dietmar, DeSouza, Mary, Murthy, Bindu
Publicado 2022

Safety, pharmacokinetics, and pharmacodynamics of milvexian in healthy Japanese participants

por Perera, Vidya, Wang, Zhaoqing, Lubin, Susan, Ueno, Takayo, Shiozaki, Tomomi, Chen, Wei, Xu, Xiaohui, Seiffert, Dietmar, DeSouza, Mary, Murthy, Bindu
Publicado 2022

Phase I study of single‐dose pharmacokinetics and pharmacodynamics of belatacept in adolescent kidney transplant recipients

por Moudgil, Asha, Dharnidharka, Vikas R., Feig, Daniel I., Warshaw, Barry L., Perera, Vidya, Murthy, Bindu, Roberts, Mustimbo E., Polinsky, Martin S., Ettenger, Robert B.
Publicado 2019

Antithrombotic Effects of Combined PAR (Protease-Activated Receptor)-4 Antagonism and Factor Xa Inhibition

por Meah, Mohammed N., Raftis, Jennifer, Wilson, Simon J., Perera, Vidya, Garonzik, Samira M., Murthy, Bindu, Everlof, J. Gerry, Aronson, Ronald, Luettgen, Joseph, Newby, David E.
Publicado 2020

First‐in‐human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS‐962212, a direct, reversible, small molecule factor XIa inhibitor in non‐Japanese and Japane...

por Perera, Vidya, Luettgen, Joseph M., Wang, Zhaoqing, Frost, Charles E., Yones, Cynthia, Russo, Cesare, Lee, John, Zhao, Yue, LaCreta, Frank P., Ma, Xuewen, Knabb, Robert M., Seiffert, Dietmar, DeSouza, Mary, Mugnier, Pierre, Cirincione, Brenda, Ueno, Takayo, Frost, Robert J. A.
Publicado 2018