Multiscale model of hepatitis C virus dynamics in plasma and liver following combination therapy

por Woot de Trixhe, Xavier, Krzyzanski, Wojciech, Vermeulen, An, Perez‐Ruixo, Juan José
Publicado 2021

Clopidogrel, a CYP2C8 inhibitor, causes a clinically relevant increase in the systemic exposure to the active metabolite of selexipag in healthy subjects

por Axelsen, Lene Nygaard, Poggesi, Italo, Rasschaert, Freya, Perez Ruixo, Juan Jose, Bruderer, Shirin
Publicado 2020

Effect of Macitentan on the Pharmacokinetics of the Breast Cancer Resistance Protein Substrates, Rosuvastatin and Riociguat, in Healthy Male Subjects

por Csonka, Dénes, Bruderer, Shirin, Schultz, Armin, Soergel, Marianne, Stepanova, Radka, Sabattini, Giancarlo, Perez-Ruixo, Juan Jose
Publicado 2019

Nicotine Population Pharmacokinetics in Healthy Smokers After Intravenous, Oral, Buccal and Transdermal Administration

por Olsson Gisleskog, Per O., Perez Ruixo, Juan José, Westin, Åke, Hansson, Anna C., Soons, Paul A.
Publicado 2020

Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

por Csonka, Dénes, Fishman, Vladislav, Natarajan, Jaya, Stieltjes, Hans, Armas, Danielle, Dishy, Victor, Perez Ruixo, Juan Jose
Publicado 2021

Receiver Operating Characteristic Analysis and Clinical Trial Simulation to Inform Dose Titration Decisions

por Clements, John David, Perez Ruixo, Juan Jose, Gibbs, John P., Doshi, Sameer, Perez Ruixo, Carlos, Melhem, Murad
Publicado 2018

Prediction of Survival Benefit of Filgrastim in Adult and Pediatric Patients With Acute Radiation Syndrome

por Harrold, John, Gisleskog, Per Olsson, Perez‐Ruixo, Juan Jose, Delor, Isabelle, Chow, Andrew, Jacqmin, Philippe, Melhem, Murad
Publicado 2020

An exposure‐response analysis of ponesimod clinical efficacy in a randomized phase III study in patients with relapsing multiple sclerosis

por Valenzuela, Belén, Olsson Gisleskog, Per, Poggesi, Italo, Sidorenko, Tatiana, Burcklen, Michel, Kracker, Hilke, Pérez‐Ruixo, Juan Jose
Publicado 2022

Mechanistic modeling projections of antibody persistence after homologous booster regimens of COVID‐19 vaccine Ad26.COV2.S in humans

por Dari, Anna, Jacqmin, Philippe, Iwaki, Yuki, Neyens, Martine, Le Gars, Mathieu, Sadoff, Jerald, Hardt, Karin, Ruiz‐Guiñazú, Javier, Pérez‐Ruixo, Juan José
Publicado 2023

Quantification of Radiation Injury on Neutropenia and the Link between Absolute Neutrophil Count Time Course and Overall Survival in Nonhuman Primates Treated with G-CSF

por Harrold, John, Gisleskog, Per Olsson, Delor, Isabelle, Jacqmin, Philippe, Perez-Ruixo, Juan Jose, Narayanan, Adimoolam, Doshi, Sameer, Chow, Andrew, Yang, Bing-Bing, Melhem, Murad
Publicado 2020

Exposure–response analyses of erdafitinib in patients with locally advanced or metastatic urothelial carcinoma

por Dosne, Anne-Gaëlle, Valade, Elodie, Goeyvaerts, Nele, De Porre, Peter, Avadhani, Anjali, O’Hagan, Anne, Li, Lilian Y., Ouellet, Daniele, Perez Ruixo, Juan Jose
Publicado 2022

A quantitative systems pharmacology model for acute viral hepatitis B

por Asín-Prieto, Eduardo, Parra-Guillen, Zinnia P., Gómez Mantilla, José David, Vandenbossche, Joris, Stuyckens, Kim, de Trixhe, Xavier Woot, Perez-Ruixo, Juan José, Troconiz, Iñaki F.
Publicado 2021

Erdafitinib’s effect on serum phosphate justifies its pharmacodynamically guided dosing in patients with cancer

por Dosne, Anne‐Gaëlle, Valade, Elodie, Stuyckens, Kim, De Porre, Peter, Avadhani, Anjali, O’Hagan, Anne, Li, Lilian Y., Ouellet, Daniele, Faelens, Ruben, Leirens, Quentin, Poggesi, Italo, Perez Ruixo, Juan Jose
Publicado 2021

Immunogenicity of panitumumab in combination chemotherapy clinical trials

por Weeraratne, Dohan, Chen, Alin, Pennucci, Jason J, Wu, Chi-Yuan, Zhang, Kathy, Wright, Jacqueline, Pérez-Ruixo, Juan José, Yang, Bing-Bing, Kaliyaperumal, Arunan, Gupta, Shalini, Swanson, Steven J, Chirmule, Narendra, Starcevic, Marta
Publicado 2011